Tuberculosis Contact Investigations — United States, 2003–2012

Young, K.; Ehman, Melissa; Reves, Randall; Maddox, Brandy L. Peterson; Khan, Abdul Qadir; Chorba, Terence; Jereb, John A.

doi:10.15585/mmwr.mm6450a1

Cited by 37 publications

(36 citation statements)

References 4 publications

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“…Contacts under 5 years or with HIV infection are the highest priorities . However, the proportion of contacts who had TB screening in our study was lower than a study in the US ; only 60% of children, 50% of contacts with HIV and 79% of contacts with DM were screened for TB. TB screening including symptomatic screening and annual chest radiography for all MDR contacts should be intensified in this district.…”

Section: Discussioncontrasting

confidence: 85%

Use of network analysis multidrug‐resistant tuberculosis contact investigation in Kanchanaburi, Thailand

Boonthanapat

Soontornmon

Pungrassami

et al. 2019

Tropical Med Int Health

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Objective To characterise MDR‐TB outbreak and incorporate social network analysis with contact investigation to detect case–contact linkages and clusters. Methods MDR‐TB cases registered in the district hospital between October 2012 and September 2015 were interviewed and their contacts were investigated. A relationship‐based weighted network was constructed. Results Among 43 interviewed MDR‐TB cases, 20 (47%) were male, five (12%) were asymptomatic (and discovered incidentally) and 22 (51%) had underlying diseases. From the documented 115 contacts, 61 (53%) were household contacts and 49 (43%) were close (non‐household) contacts; 70 (61%) were screened for TB using various tests. In this network, we prioritised 37 contacts connected with more than one MDR‐TB patient. The largest cluster was identified in the pharmacy unit of the hospital. Conclusion This investigation yielded a significant number of MDR‐TB contacts, and social network analysis facilitated the prioritisation for screening. Social network analysis is useful and feasible in this program setting and complements MDR‐TB contact investigation.

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Section: Discussioncontrasting

confidence: 85%

Use of network analysis multidrug‐resistant tuberculosis contact investigation in Kanchanaburi, Thailand

Boonthanapat

Soontornmon

Pungrassami

et al. 2019

Tropical Med Int Health

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“…6,13 Conversely, delays in diagnosis still occur, and most programmes do not meet targets for testing and treatment initiation and completion for latent tuberculosis infection in contact investigations. 14–16 For strategy 2, data for testing and treatment for latent tuberculosis infection indicate that whereas treatment is initiated in several hundred thousand people with latent tuberculosis infection per year, the infection is present in up to 13 million people. 17,18 New tools developed under strategy 3, such as IGRAs and nucleic acid amplification tests, have been mostly helpful, but are incremental rather than transformational improvements.…”

Section: Ending Historical Neglect: Tuberculosis Elimination Revisitedmentioning

confidence: 99%

“…People can fail to complete any of these steps and the effect is multiplicative, as shown in an analysis 16 of US contact investigations (figure 3). There are several factors that make testing and treatment of latent tuberculosis infection challenging.…”

Section: The Latent Tuberculosis Infection Prevention Cascadementioning

confidence: 99%

“…The only national reporting related to latent tuberculosis infection is for contact investigation, and this system is limited to aggregate (rather than individual line-listed) reporting for latent tuberculosis infection testing and treatment. 16 To adequately monitor progress in addressing latent tuberculosis infection, a more complete, individual case-based registry or surveillance system is needed.…”

Section: A Potential Approach To Expansion Of Latent Tuberculosis Infmentioning

confidence: 99%

See 1 more Smart Citation

Latent tuberculosis infection: the final frontier of tuberculosis elimination in the USA

LoBue

Mermin

2017

The Lancet Infectious Diseases

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Since 1989, the USA has been pursuing the goal of tuberculosis elimination. After substantial progress during the past two decades, the rate of tuberculosis cases in the USA each year has now levelled off and remains well above the elimination threshold. Both epidemiological data and modelling underline the necessity of addressing latent tuberculosis infection if further progress is to be made in eliminating the disease. In this Personal View we explore next steps towards elimination. Given the estimated prevalence of latent tuberculosis infection, compared with the limited testing and treatment that currently occur, a major new effort is required. This effort should consist of a surveillance system or registry to monitor progress, scale-up of targeted testing for latent tuberculosis infection in at-risk populations, scale-up of short-course treatment regimens, engagement of affected communities and medical providers who serve those communities, and increased public health staffing for implementation and oversight. Such an effort would benefit greatly from the development of new tools, such as tests that better indicate reactivation risk, and even shorter latent tuberculosis infection treatment regimens than currently exist.

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“…Tuberculosis patients in the United States have, on average, 11 contacts who may be at risk for tuberculosis infection; and of those, an average of three contacts become infected and may develop disease if not diagnosed and treated. 21 Public health departments make every effort to identify those who have been in close contact with someone who has infectious tuberculosis disease, and they can provide information on exposure risk to concerned individuals who know someone who has been included or have themselves been included in contact investigations.…”

Section: Latent Tuberculosis Infection Risk Assessment Testing and mentioning

confidence: 99%

Ce

Parmer

Allen

Walton

2017

AJN, American Journal of Nursing

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Nurses play a critical role in the diagnosis and treatment of tuberculosis and in the prevention of tuberculosis transmission through infection control practices. To eliminate tuberculosis in the United States, however, an expanded approach to testing and treating people with latent tuberculosis infection must be implemented. Recently, the U.S. Preventive Services Task Force (USPSTF) issued a new recommendation statement on latent tuberculosis infection testing that expands nurses’ opportunities to identify at-risk populations for tuberculosis prevention. In combination with newer testing methodologies and shorter treatment regimens, implementation of the USPSTF recommendation has the potential to remove previously existing barriers to screening and treatment of both patients and health care providers. This article provides a general overview of tuberculosis transmission, pathogenesis, and epidemiology; presents preventive care recommendations for targeted testing among high-risk groups; and discusses the USPSTF recommendation’s applicability to public health and primary care practice in the United States.

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Tuberculosis Contact Investigations — United States, 2003–2012

Cited by 37 publications

References 4 publications

Use of network analysis multidrug‐resistant tuberculosis contact investigation in Kanchanaburi, Thailand

Use of network analysis multidrug‐resistant tuberculosis contact investigation in Kanchanaburi, Thailand

Latent tuberculosis infection: the final frontier of tuberculosis elimination in the USA

Ce

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