Tuberculosis e ictericia. Importancia de su asociacion

Pilheu, Jorge A.; Salvo, María Cristina de; Barcat, Juan Antonio; Koch, O.

doi:10.1016/s0300-2896(15)32064-0

Cited by 2 publications

(3 citation statements)

References 13 publications

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“…High rates of jaundice and fulminant hepatitis were recorded in both adults and children after tuberculosis treatment with these medicines. Furthermore, the combination of INH, RIF, and PYR in short-term tuberculosis treatment was related with hepatotoxic symptoms in 15% of patients, with 2 to 3% developing jaundice [16,86]. Hepatotoxicity caused by anti-tubercular medicines is now widely recognized as a serious and sometimes fatal adverse effect, especially among patients receiving active tuberculosis treatment [82].…”

Section: Atds Induced Hepatotoxicitymentioning

confidence: 99%

“…AZT treatment has been associated with hepatotoxicity-related fatalities, characterized by lipid dysregulation, steatosis, steatohepatitis, hepatomegaly, and abnormal liver function [14,94]. Despite INH's proven efficacy in TB prevention, its administration has been linked to hepatic necrosis and steatosis, with approximately 15% of TB patients undergoing INH therapy experiencing hepatotoxicity, including 2 to 3% developing jaundice [86]. Combined AZT and INH treatments in HIV patients co-infected with TB have been shown to induce severe hepatotoxicity, for which remedial measures remain undefined [11,13,18] (Figure 1).…”

Section: Hiv/aids Co-infection With Tb In Humans and Use Of Azt And I...mentioning

confidence: 99%

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The Healing Power of Plants: Herbal Compounds as Guardians against Antiretroviral and Antitubercular Drugs-Induced Hepatotoxicity

Ramanathan

2024

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Drugs are known to cause substantial liver injury, with hepatotoxicity ranging from asymptomatic increase of liver enzymes to hepatic failure. HIV/AIDS patients, with compromised immune systems, are especially vulnerable to opportunistic infections such as tuberculosis (TB). Patients with co-infection frequently get combined antiretroviral (ART) and antitubercular (ATD) regimens, which can cause hepatotoxicity. Hepatotoxicity has been linked to commonly administered antiretroviral drug regimens as well as first-line antitubercular agents such isoniazid, rifampin, and pyrazinamide, which are required for the treatment of both drug-sensitive and drug-resistant tuberculosis. As a result, there is an urgent need to investigate treatments based from traditional herbs known for their hepatoprotective abilities against ART and ATD-induced liver injury. Many researchers have investigated the effectiveness of medicinal plants in treating chemically caused hepatotoxicity. Medicinal plants are high in phytochemicals and secondary metabolites, both of which have a variety of medicinal benefits. Currently, there is a lack of specific therapeutic regimens to address this adverse effect, and management often relies on symptomatic treatment or therapy withdrawal. Traditional medicinal plants may have the potential to restore normal liver function, enzyme activity, and cellular structure in response to ART and ATD-induced hepatotoxicity. This review aims to examine the scientific evidence supporting the use of medicinal plants as hepatoprotective agents against liver damage induced by ART and ATDs.

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Section: Atds Induced Hepatotoxicitymentioning

confidence: 99%

Section: Hiv/aids Co-infection With Tb In Humans and Use Of Azt And I...mentioning

confidence: 99%

The Healing Power of Plants: Herbal Compounds as Guardians against Antiretroviral and Antitubercular Drugs-Induced Hepatotoxicity

Ramanathan

2024

Preprint

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“…10), suggesting that the reactive metabolite of INH can directly bind to mitochondrial protein, and this may be responsible for the induction of steatosis. Steatosis has also been observed in a few clinical cases of INH-induced liver injury (Pessayre et al, 1977;Pilheu et al, 1979Pilheu et al, , 1981. However, these cases involve administration of INH together with other drugs such as rifampin, ethambutol, and pyrazinamide, and these cases do not involve the common histologic feature of hepatocellular necrosis, which is observed in most cases of INH-induced liver failure (Maddrey and Boitnott, 1973).…”

Section: Attenuation Of Autoimmune Hepatitis 969mentioning

confidence: 99%

Paradoxical Attenuation of Autoimmune Hepatitis by Oral Isoniazid in Wild-Type andN-Acetyltransferase–Deficient Mice

et al. 2014

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Isoniazid (INH) treatment can cause serious liver injury and autoimmunity. There are now several lines of evidence that INHinduced liver injury is immune mediated, but this type of liver injury has not been reproduced in animals, possibly because immune tolerance is the dominant response of the liver. In this study, we immunized mice with isonicotinic acid (INA)-modified proteins and Freund's adjuvant, which led to mild experimental autoimmune hepatitis (EAH) with an increase in cells staining positive for F4/80, CD11b, CD8, CD4, CD45R, and KI67. We expected that subsequent treatment of mice with oral INH would lead to more serious immune-mediated liver injury, but paradoxically it markedly attenuated the EAH caused by immunization with INA-modified hepatic proteins. In addition, patients of the slow acetylator phenotype are at increased risk of INH-induced liver injury. Treatment of arylamine N-acetyltransferase-deficient Nat1/2(2/2) mice with INH for up to 5 weeks produced mild increases in glutamate and sorbitol dehydrogenase activities, but not severe liver injury. Female Nat1/2(2/2) mice treated with INH for 1, 3, or 7 days developed steatosis, an increase in Oil Red O staining, and abnormal mitochondrial morphology in the liver. A decrease in M1 and an increase in M2a and M2b macrophages was observed in female Nat1/2(2/2) mice treated with INH for 1, 3, or 7 days; these changes returned to baseline levels by day 35. These data indicate that INH has immunosuppressive effects, even though it is also known to induce autoantibody production and a lupuslike autoimmune syndrome in humans.

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Tuberculosis e ictericia. Importancia de su asociacion

Cited by 2 publications

References 13 publications

The Healing Power of Plants: Herbal Compounds as Guardians against Antiretroviral and Antitubercular Drugs-Induced Hepatotoxicity

The Healing Power of Plants: Herbal Compounds as Guardians against Antiretroviral and Antitubercular Drugs-Induced Hepatotoxicity

Paradoxical Attenuation of Autoimmune Hepatitis by Oral Isoniazid in Wild-Type andN-Acetyltransferase–Deficient Mice

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