Tuberculosis in pregnancy: an estimate of the global burden of disease

Sugarman, Jordan; Colvin, Charlotte; Moran, Allisyn C.; Oxlade, Olivia

doi:10.1016/s2214-109x(14)70330-4

Cited by 164 publications

(151 citation statements)

References 21 publications

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“…1 Clinically, tuberculosis can manifest either as meningitis or tuberculomas. 2 The signs and symptoms in cerebral tuberculosis depend upon the location of the lesion.…”

Section: Discussionmentioning

confidence: 99%

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Giant cerebral tuberculoma in pregnancy: review of literature discussion

Malhotra

2016

Int Surg J

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“…1 Clinically, tuberculosis can manifest either as meningitis or tuberculomas. 2 The signs and symptoms in cerebral tuberculosis depend upon the location of the lesion.…”

Section: Discussionmentioning

confidence: 99%

“…Keywords: Cerebral tuberculoma, Pregnancy, Spectroscopy, Intracranial space occupying lesion 1 Department of Neurosurgery, Government Medical College Chandigarh, India 2 ESI Hospital, Chandigarh, India…”

Section: Introductionmentioning

confidence: 99%

Giant cerebral tuberculoma in pregnancy: review of literature discussion

Malhotra

2016

Int Surg J

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“…1 These infections can make up to 28% of maternal deaths. 2 Maternal tuberculosis can remain unrecognised and an underestimated tragedy. 3 Tuberculosis still remains the leading infectious cause of death in women worldwide, creating orphans, impoverished families and reduces the economic development of society.…”

Section: Introductionmentioning

confidence: 99%

Tuberculosis in Pregnancy: Delayed Diagnosis, Lost Lives

Ngwenya¹

2017

Pulm Res Respir Med Open J

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Tuberculosis still remains an important global health disease, killing many people annually. Yet it is a preventable cause of death. Maternal mortality rates due to tuberculosis and HIV/AIDS in Sub-Saharan Africa make up a significant proportion of maternal deaths. It remains a disease of poverty, overcrowding and underdevelopment. Pregnancy increases maternal and fatal mortality in AIDS-infected women. In pregnancy it can be a challenging diagnosis to make, delaying treatment that could lead to adverse outcomes. Clinicians working in high prevalence areas of tuberculosis and those looking after immunocompromised patients should maintain a high index of suspicion. Developing countries must be helped to develop by the world financial institutions with debt reduction. The Sustainable Development Goal aims to end tuberculosis related deaths, transmission and catastrophic costs by 2030. Tuberculosis is a preventable death, the world must act together to prevent unnecessary deaths.

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“…1 In 2011, there were an estimated 216,500 (95% uncertainty range 192,100 to 247,000) active tuberculosis cases in pregnant women. 2 Pregnancy itself appears to be a risk factor for developing TB. 3 The increased susceptibility to TB may be due to immunological changes in pregnancy.…”

Section: Introductionmentioning

confidence: 99%

Tuberculosis and Pregnancy: An Updated Systematic Review

Repossi¹,

Bothamley²

2015

Pulm Res Respir Med Open J

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Tuberculosis (TB) affects women, especially in the child-bearing years. TB is associated with a poorer outcome of pregnancy, although this may be due to the general risk factors for TB, namely poverty, malnutrition and overcrowding. New studies have shown that symptom screening has a low sensitivity and specificity, but is improved by the addition of a tuberculin skin test (TST) or interferon-gamma release assay (IGRA) or, in high incidence areas, DNA amplification tests (e.g. Xpert MTB/RIF). TB-HIV co-infection is a common cause of mortality and morbidity in pregnancy. The diagnostic process remains the same in pregnancy, but non-specific symptoms and extra pulmonary disease demand a higher level of suspicion of TB. Standard first-line treatment is safe in pregnancy. Data on second-line drugs in pregnancy is still limited, but injectable drugs may affect the hearing and balance of the fetus. The IGRA responses appear to change during pregnancy, with more positive responses after delivery. The increasing incidence of drug-resistant TB, especially in Eastern Europe and Central Asia, requires an evaluation of the safety of second-line drugs in pregnancy.

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Tuberculosis in pregnancy: an estimate of the global burden of disease

Cited by 164 publications

References 21 publications

Giant cerebral tuberculoma in pregnancy: review of literature discussion

Giant cerebral tuberculoma in pregnancy: review of literature discussion

Tuberculosis in Pregnancy: Delayed Diagnosis, Lost Lives

Tuberculosis and Pregnancy: An Updated Systematic Review

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