Tuberculosis incidence in patients with chronic kidney disease: a systematic review and meta-analysis.

Alemu, Ayinalem; Bitew, Zebenay Workneh; Diriba, Getu; Seid, Getachew; Eshetu, Kirubel; Chekol, Musse Tadesse; Berhe, Nega; Gumi, Balako

doi:10.1016/j.ijid.2022.05.046

Cited by 13 publications

(12 citation statements)

References 42 publications

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“…Studies indicate a 3‐ to ‐25‐fold higher risk in these patients compared to healthy individuals 14 . A systematic review and meta‐analysis study stated the incidence of extrapulmonary TB to be 2227/100,000 compared to pulmonary TB being 1786/100,000 showing that extrapulmonary TB is more common in patients with CKD than pulmonary TB 15 . Furthermore, impaired cell‐mediated immunity in dialysis predisposes patients to infections and their complications 13 …”

Section: Discussionmentioning

confidence: 99%

“…1786/100,000 showing that extrapulmonary TB is more common in patients with CKD than pulmonary TB. 15 Furthermore, impaired cell-mediated immunity in dialysis predisposes patients to infections and their complications. 13 CKD being an independent risk factor for TB and hemodialysis being a predisposing factor may have contributed as etiological factors for tuberculoma in this case.…”

Section: F I G U R E 3 Intraoperative Image Showing a Mass Lesionmentioning

confidence: 99%

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A rare extrapulmonary manifestation of tuberculosis in a chronic kidney disease patient

Sivanandam,

Jhoond,

Sujanyal

et al. 2023

Clinical Case Reports

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Key Clinical MessageChronic kidney disease (CKD) and tuberculoma are two distinct medical conditions. Nonetheless, they can be related in very rare cases. The purpose of this case report is to consider screening tests such as IGRA (interferon gamma release assay) and TST (tuberculin skin test), for tuberculosis in CKD patients with a risk of infection, thereby increasing the awareness of tuberculoma in CKD and ensuring early treatment which would eventually decrease the morbidity and mortality rates in such patients.AbstractChronic kidney disease (CKD) associated with tuberculoma represents one of the rarest conditions occurring worldwide. Among tuberculous patients, only 1% show central nervous system involvement. We present a case of a 45‐year‐old male with CKD who presented with a seizure and was diagnosed to have tuberculoma.

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Section: Discussionmentioning

confidence: 99%

Section: F I G U R E 3 Intraoperative Image Showing a Mass Lesionmentioning

confidence: 99%

A rare extrapulmonary manifestation of tuberculosis in a chronic kidney disease patient

Sivanandam,

Jhoond,

Sujanyal

et al. 2023

Clinical Case Reports

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“…Other conditions increase the risk of progression from infection to disease. These include silicosis (RR 4-30) [115,116], kidney failure (RR 10-25) [117,118], rheumatoid arthritis (RR 2-16) [111] and cancer (RR 2-40) [119][120][121]. In each of the conditions, the immune system is affected by the required treatment, making the patient less capable of self containing M. tuberculosis infection.…”

Section: Other Risk Factorsmentioning

confidence: 99%

Epidemiology: the current burden of tuberculosis and its determinants

Verstraeten,

Cossa,

Martinez

et al. 2023

The Challenge of Tuberculosis in the 21st Century

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“…In a recent meta-analysis, Alemu et al reported that patients with KT had a pooled incidence of active TB of 2700 (95% CI: 1878-3522) per 100,000 patient-years, which ranged from 340 per 100,000 patient-years in low TB burden countries to 14,680 per 100,000 patientyears in countries with high endemicity [67]. In the same study, the pooled incidence of active TB in KT recipients was higher than in patients with ESRD in pre-dialysis (2700 (95% CI: 1878-3522) vs. 913 (95% CI: 407-1418) per 100,000 person-years) but lower than in those on peritoneal dialysis and hemodialysis (2700 (95% CI: 1878-3522) vs. 3533 (95% CI: 2220-4846) and 5611 (95% CI: 4186-7035) per 100,000 person-years, respectively).…”

Section: Epidemiology Of Tuberculosis In Kidney Transplantationmentioning

confidence: 99%

Mycobacterium Tuberculosis Infection after Kidney Transplantation: A Comprehensive Review

et al. 2022

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Tuberculosis (TB) in kidney transplant (KT) recipients is an important opportunistic infection with higher incidence and prevalence than in the general population and is associated with important morbidity and mortality. We performed an extensive literature review of articles published between 1 January 2000 and 15 June 2022 to provide an evidence-based review of epidemiology, pathogenesis, diagnosis, treatment and outcomes of TB in KT recipients. We included all studies which reported epidemiological and/or outcome data regarding active TB in KT, and we approached the diagnostic and treatment challenges according to the current guidelines. Prevalence of active TB in KT recipients ranges between 0.3–15.2%. KT recipients with active TB could have a rejection rate up to 55.6%, a rate of graft loss that varies from 2.2% to 66.6% and a mortality rate up to 60%. Understanding the epidemiological risk, risk factors, transmission modalities, diagnosis and treatment challenges is critical for clinicians in providing an appropriate management for KT with TB. Among diagnostic challenges, which are at the same time associated with delay in management, the following should be considered: atypical clinical presentation, association with co-infections, decreased predictive values of screening tests, diverse radiological aspects and particular diagnostic methods. Regarding treatment challenges in KT recipients with TB, drug interactions, drug toxicities and therapeutical adherence must be considered.

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Tuberculosis incidence in patients with chronic kidney disease: a systematic review and meta-analysis.

Cited by 13 publications

References 42 publications

A rare extrapulmonary manifestation of tuberculosis in a chronic kidney disease patient

A rare extrapulmonary manifestation of tuberculosis in a chronic kidney disease patient

Epidemiology: the current burden of tuberculosis and its determinants

Mycobacterium Tuberculosis Infection after Kidney Transplantation: A Comprehensive Review

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