Tuberculosis Maintenance Therapy With Isoniazid and Ethambutol

Lees, A.W.; Allan, G.W.; Smith, J.; Tyrrell, W.F.

doi:10.1016/s0140-6736(80)90402-x

Cited by 6 publications

(2 citation statements)

References 1 publication

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“…Maintenance therapy with lesser number of drugs is of a paramount importance specially in endemic zones. In the intensive phase of treatment multiplying organisms are killed by the ATT drugs, but the dormant organisms stay in the bone and could multiply eventually leading to relapse 24…”

Section: Discussionmentioning

confidence: 99%

Tuberculosis of lunate as an isolated intraosseous osteolytic lesion in an adult: a diagnostic challenge

Kumar¹,

Aggarwal

Rajnish

et al. 2019

BMJ Case Rep

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In an endemic zone of tuberculosis (TB), osseous involvement is a relatively common presentation. Spine and long bones are the the most common nidus of TB. Smaller bones and joints are relatively less involved. Thorough clinical examination and history of typical constitutional symptoms like weight loss, fever and loss of appetite are the diagnostic aids for initiating early treatment. Wrist and hand involvement is a rare occurrence and often presents atypically without any obvious symptoms or signs. This results in delayed diagnosis and worse outcome. TB of lunate without articular involvement is a very rare subset and we present such an isolated case of TB involving the lunate, without any typical symptoms, with the patient complaining of vague pain without any restriction of joint mobility. TB was diagnosed with the aid of radiology, haematology and histopathology. 18 months of multidrug antitubercular treatment was given, to which the patient responded well.

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Section: Discussionmentioning

confidence: 99%

Tuberculosis of lunate as an isolated intraosseous osteolytic lesion in an adult: a diagnostic challenge

Kumar¹,

Aggarwal

Rajnish

et al. 2019

BMJ Case Rep

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“…LEES and eo-workers (14)(15)(16) have shown that rifampicin and isoniazid for two months followed by isoniazid and ethambutol to a total of 12 months was effective in treating pulmonary tuberculosis. Rifampicin is probably a superior single agent and has a special role in reducing the total duration of treatment and hence our treatment schedule should be adequate.…”

Section: Discussionmentioning

confidence: 99%

Isoniazid resistant tuberculosis in a school outbreak: the protective effect of BCG

Shannon¹,

Kelly²,

Lucey³

et al. 1991

Eur Respir J

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An outbreak of isoniazid resistant tuberculosis occurred in a large second level school. A total of 1,160 teenage pupils were at risk. Nineteen cases of tuberculosis were diagnosed, 15 were students, 9 of whom were among 251 non-vaccinated students and 6 among 909 vaccinated students. Two cases of miliary tuberculosis, one of whom also had tuberculous (TB) meningitis, occurred in the non-vaccinated group. The number of children with Heaf grade +3 or +4 was significantly greater among children who had been given Bacille Calmette-Guerin (BCG) vaccination (8 vs 4.4%). This suggests a boosting effect on the response in vaccinated children. The protective effect of neonatal BCG vaccination in this school outbreak suggests that it provides significant protection against tuberculosis lasting into adolescence.

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Mycobacterial infections in renal transplant recipients. Seven cases and a review of the literature

Lloveras¹,

Peterson²,

Simmons³

et al. 1982

Archives of Internal Medicine

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During an 11-year period, 1,069 patients received renal allografts at the University of Minnesota Hospital, Minneapolis, and infections developed in seven (0.65%) due to mycobacteria (Mycobacterium tuberculosis and M kansasii). The primary infection was in joint or subcutaneous tissue in six patients and pulmonary (miliary) in one. Infections in joint or skin shared common features regardless of the species of Mycobacterium and usually mimicked acute pyogenic bacterial infection; all responded to antimycobacterial drugs. The clinical manifestations in our patient in miliary tuberculosis were compared with those of 19 other patients described in the literature. Although their systemic manifestations were more severe, the symptoms were often ill-defined and the diagnosis overlooked. Five of these 20 patients (25%) died of uncontrolled infection.

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Tuberculosis Maintenance Therapy With Isoniazid and Ethambutol

Cited by 6 publications

References 1 publication

Tuberculosis of lunate as an isolated intraosseous osteolytic lesion in an adult: a diagnostic challenge

Tuberculosis of lunate as an isolated intraosseous osteolytic lesion in an adult: a diagnostic challenge

Isoniazid resistant tuberculosis in a school outbreak: the protective effect of BCG

Mycobacterial infections in renal transplant recipients. Seven cases and a review of the literature

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