Tuberculosis Treated With Promin

Pharmacology of Sulphonamides: Recent Work

“…), but being soluble it does not cause urinary blockage.. The various toxic effects indicate that it should be given only under careful supervision (Hinshaw, Pfuetze, and Feldman, 1943;Heaf, Hurford, Eiser, and Franklin, 1943). Another compound of this type has -been introduced recentlyviz., promizole.…”

Chemotherapy of Tuberculosis--Part II

“…The results showed this substance to be a striking inhibitor of the progress of the disease in guinea-pigs (the few observations made in mice-e.g., by Glover in 1945-were much less favourable). But when promin was tested in human pulmonary tuberculosis, although limited benefit was reported by some, the tolerance was found to be considerably lower than in the guinea-pig when the drug was given orally, unpleasant reactions-e g., a (reversible) anaemiaoccurring with some frequency; and while the toxic symptoms were much less evident after parenteral administration, so also was the clinical benefit (Zucker, Pinner, and Hyman, 1942;Heaf et al, 1943;Hinshaw, Pfuetze, and Feldman, 1944;Dancey, Schmidt, and Wilkie, 1944). Experience with " diazone" in experimental tuberculosis in guinea-pigs resembled that with promin (see Tytler), but trials in human pulmonary disease produced conflicting reports, the majority of them unfavourable (Petter and Prenzlau, 1944;Benson and Goodman, 1945 ;Olson et al, 1945 ;Pfuetze, 1945 ;Tice, Sweany, and Davison, 1946;Robitzek et al.…”

Survey of the Literature on Tuberculosis--1940-1943

“…Heaf and his collaborators 116 give an interim report on their clinical experiments with promin (sodi um , '-diaminodiphenylsulfone-, '-didextrose sulfonate). Among the 19 tuberculous patients were 4 with laryngeal tuberculosis, in 2 of whom the lesions were treated with a powder consisting of promin, orthoform and starch in equal amounts, insufflated directly on the in¬ volved tissues through a Ledue tube.…”