Tuberculous dacryoadenitis unveils HIV infection

Toledano, Nicolas; Stoica, Bazil; Saavedra, I. Genol; Saenz, Sofia Garcia; Conde, Esther

doi:10.1016/j.jcjo.2013.05.008

Cited by 6 publications

(9 citation statements)

References 10 publications

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“…Both cases were diagnosed with biopsy and responded well to treatment with anti-TB therapy. In all but the single case from the UK,9 the TB dacryoadenitis occurred in immigrants from endemic areas 10 11. We found no previously documented cases of dacryoadenitis in the USA.…”

Section: Discussionmentioning

confidence: 54%

“…TB dacryoadenitis presents with a superotemporal orbital mass, usually without heat or erythema 10 11. It has also been noted to present with proptosis or regional lymphadenopathy 12.…”

Section: Discussionmentioning

confidence: 99%

“…The median duration of symptoms before evaluation is 5 months, and it has a female predominance. It is hypothesised that dacryoadenitis is secondary to haematogenous spread of MTB during primary infection, which then reactivates 11…”

Section: Discussionmentioning

confidence: 99%

“…Presumptive diagnosis usually involves suspicious clinical histopathological findings plus 1 of the following: systemic findings consistent with TB infection, positive interferon gamma release assay or positive tuberculin skin test 14. Diagnosis can be substantiated through response to treatment 9–11…”

Section: Discussionmentioning

confidence: 99%

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Tuberculosis presenting as dacryoadenitis in the USA

2019

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A 25-year-old Filipino woman living in the USA was evaluated for a 5-month history of left eye pain and a subsequent orbital mass. Histopathological analysis of the lacrimal mass showed a mixed inflammatory process with necrotising granulomas and positive cultures for Mycobacterium tuberculosis. She was treated with antituberculosis therapy, with resolution of symptoms. Tuberculosis dacryoadenitis is extremely rare in the USA and other developed countries. It requires a high degree of clinical suspicion with special attention to the patient’s history to make the correct diagnosis. It can be treated successfully with antituberculosis therapy.

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Section: Discussionmentioning

confidence: 54%

“…TB dacryoadenitis presents with a superotemporal orbital mass, usually without heat or erythema 10 11. It has also been noted to present with proptosis or regional lymphadenopathy 12.…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Tuberculosis presenting as dacryoadenitis in the USA

2019

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“…Given the reactivation of TB infection, serologies for HIV were drawn and found to be positive, demonstrating the importance of testing for HIV if mycobacterial dacryoadenitis is diagnosed. 44 Definitive diagnosis of TB dacryoadenitis is achieved by isolation of mycobacterium bacilli from the ocular tissue through orbital biopsy. Histopathologically, TB is confirmed by the presence of epithelioid granulomas with Langhans giant cells and caseating necrosis.…”

Section: Mycobacterialmentioning

confidence: 99%