Tubulization Increases Axonal Outgrowth of Rat Sciatic Nerve after Crush Injury

Danielsson, Pär; Dahlin, Lars B.; Povlsen, Bo

doi:10.1006/exnr.1996.0097

Cited by 24 publications

(17 citation statements)

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“…The use of a conduit at the site of injury has experimentally been demonstrated to improve peripheral regeneration. 15 Clinically, promising results of enclosing the nerve ends in silicone tubes have been found. 11 Enclosing the nerve ends in a conduit enhances the local concentration of growth factors like neurotrophins 13,28,41,42 and cellular elements such as macrophages.…”

Section: Discussionmentioning

confidence: 96%

“…11,12 The idea of repair by entubulation is based on the theory that growth-promoting factors accumulating in the gap between the nerve ends will support axonal regeneration. [13][14][15] Poly-␤-hydroxybutyrate (PHB) is a biodegradable polymer naturally existing in microorganisms as energy storage granules. 16,17 It can be produced from bacterial cultures 16 and then harvested and processed into materials suitable for different purposes.…”

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confidence: 99%

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Neuronal survival using a resorbable synthetic conduit as an alternative to primary nerve repair

Ljungberg

Johansson-Rudén²,

Kj³

et al. 1999

Microsurgery

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Clinically optimal situations for primary nerve repair are rarely observed. Crushed nerve ends result in either suboptimal repair or a need for nerve grafting. Functional results after nerve surgery are relatively poor, including major sensory deficits, which may be due to the death of primary sensory neurons that follows the nerve injury. The aim of this study was to determine if using polyhydroxybutyrate (PHB), a resorbable nerve conduit, could be an alternative to primary nerve repair in reducing loss of neurons. The superficial radial nerves in 20 cats were sectioned bilaterally and primarily repaired microsurgically by the use of two different strategies; either wrapping the nerve ends in sheets of PHB or epineurally suturing of the nerve. After 6 or 12 months, the surviving neurons within the dorsal root ganglia [C5-T1] were counted. No statistically significant differences were found between the two methods. This may imply a future possibility of using PHB as a synthetic nerve graft in situations where suboptimal primary repair or nerve grafts are the alternatives.

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Section: Discussionmentioning

confidence: 96%

mentioning

confidence: 99%

Neuronal survival using a resorbable synthetic conduit as an alternative to primary nerve repair

Ljungberg

Johansson-Rudén²,

Kj³

et al. 1999

Microsurgery

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show abstract

“…Over the last couple of years, people have done a lot of research on the apposition of functionally corresponding fascicules by means of anatomy and immunohistochemistry in order to achieve the accurate apposition but most of them failed to find application in the clinical practice. Nerve selected regeneration theory was put forward by Cajal et al [2] and was confirmed by some researchers in the last decade [6][7][8][9]. Cajal demonstrated in the neural regenerative chamber model that a great deal of sprouts grow from the proximal stumps and preferentially into the distal corresponding degenerated and regenerated myelinated sheaths composed by Schwann cells, namely sensory nerve fibers grow into distal sensory nerve myelinated sheaths and motor nerve fibers grow into distal motor nerve myelinated sheaths.…”

Section: Discussionmentioning

confidence: 97%

Study on Small Gap Sleeve Bridging Peripheral Nerve Injury

Jiang

Zhang

et al. 2006

Artificial Cells, Blood Substitutes, and Biotechnology

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Epineurium or perineurium neurorrhaphy to recover the nerve continuity was the choice of peripheral nerve mutilation. The nerve selective regeneration theory was put forth by Cajal et al. As this theory was gradually accepted, many researchers had focused on it and its possible application. Our labs had centered on the small gap sleeve bridging fields for about 30 years, using autogeneic vein, artery and biogradable chitin conduits. Our goal was to improve the nerve regeneration effect by means of nerve selective regeneration theory and degradable biomaterials. This serial experiment was to confirm the possibilities of using conduit small gap sleeve bridging to substitute the traditional epineurium neurorrhaphy.

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“…For example, studies by Davies et al [73] have shown that when endogenous fibrous components in the glia scar are aligned correctly, axonal outgrowth can be observed across the damaged spinal cord. The neuroarchitecture of the spinal cord is highly organized with parallel tracts of neurites and axons and thus, its repair may benefit from a hydrogel with organized architecture, such as nanofibers or nanotubes [33,167,168,169,170,171]. Implantation of hydrogels into white matter, such as in the spinal cord or corpus callosum, will limit access to free water and thus slow the hydrolytic degradation compared to grey matter [105,111,112,115].…”

Section: Physical Formationmentioning

confidence: 99%

Building Biocompatible Hydrogels for Tissue Engineering of the Brain and Spinal Cord

Aurand

Wagner

Lanning

et al. 2012

JFB

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Tissue engineering strategies employing biomaterials have made great progress in the last few decades. However, the tissues of the brain and spinal cord pose unique challenges due to a separate immune system and their nature as soft tissue. Because of this, neural tissue engineering for the brain and spinal cord may require re-establishing biocompatibility and functionality of biomaterials that have previously been successful for tissue engineering in the body. The goal of this review is to briefly describe the distinctive properties of the central nervous system, specifically the neuroimmune response, and to describe the factors which contribute to building polymer hydrogels compatible with this tissue. These factors include polymer chemistry, polymerization and degradation, and the physical and mechanical properties of the hydrogel. By understanding the necessities in making hydrogels biocompatible with tissue of the brain and spinal cord, tissue engineers can then functionalize these materials for repairing and replacing tissue in the central nervous system.

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Tubulization Increases Axonal Outgrowth of Rat Sciatic Nerve after Crush Injury

Cited by 24 publications

References 0 publications

Neuronal survival using a resorbable synthetic conduit as an alternative to primary nerve repair

Neuronal survival using a resorbable synthetic conduit as an alternative to primary nerve repair

Study on Small Gap Sleeve Bridging Peripheral Nerve Injury

Building Biocompatible Hydrogels for Tissue Engineering of the Brain and Spinal Cord

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