Tubulointerstitial nephritis and uveitis syndrome: recognizing the importance of an uncommon disease

Levinson, Ralph D.; Mandeville, John; Holland, Gary N.; Rosenbaum, James T.

doi:10.1016/s0002-9394(00)00483-9

Cited by 15 publications

(7 citation statements)

References 13 publications

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“…The true frequency of chronic uveitis in TINU syndrome may be higher than previously reported. 1,21 Nonetheless, the recruitment of study participants from the referral practices of uveitis specialists may have caused a selection bias that resulted in a subset of patients with chronic uveitis. Although unlikely, it is possible that the association of TINU syndrome with specific HLA alleles found in this report reflects an association with a subpopulation of patients.…”

Section: Discussionmentioning

confidence: 99%

Strong Associations between Specific HLA-DQ and HLA-DR Alleles and the Tubulointerstitial Nephritis and Uveitis Syndrome

Levinson¹,

Park

Rikkers³

et al. 2003

Invest. Ophthalmol. Vis. Sci.

136

103

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TINU syndrome is strongly associated with HLA-DQA1*01, HLA-DQB1*05, and HLA-DRB1*01. The association with HLA-DRB1*0102 is one of the highest reported for any disease. Because these genes are in linkage disequilibrium, the role of the individual alleles is difficult to assess. Based on the results of the present study and on previously reported HLA associations in patients with TINU syndrome, the alphabeta dimer encoded by HLA-DQA1*01/DQB1*05 may be particularly important in conferring risk for development of this disease.

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Section: Discussionmentioning

confidence: 99%

Strong Associations between Specific HLA-DQ and HLA-DR Alleles and the Tubulointerstitial Nephritis and Uveitis Syndrome

Levinson¹,

Park

Rikkers³

et al. 2003

Invest. Ophthalmol. Vis. Sci.

136

103

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“…TINU accounts for less than 2 % of cases of uveitis [1, 51, 52]. The median age at presentation is 15 years and the female to male ratio is 3:1 [52, 53].…”

Section: Introductionmentioning

confidence: 99%

Tubulointerstitial nephritis: diagnosis, treatment, and monitoring

et al. 2016

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Tubulointerstitial nephritis (TIN) is a frequent cause of acute kidney injury (AKI) that can lead to chronic kidney disease (CKD). TIN is associated with an immune-mediated infiltration of the kidney interstitium by inflammatory cells, which may progress to fibrosis. Patients often present with non-specific symptoms, which can lead to delayed diagnosis and treatment of the disease. Etiology of TIN can be drug-induced, infectious, idiopathic, genetic, or related to a systemic inflammatory condition such as tubulointerstitial nephritis and uveitis (TINU) syndrome, inflammatory bowel disease, or IgG4-associated immune complex multiorgan autoimmune disease (MAD). It is imperative to have a high clinical suspicion for TIN in order to remove potential offending agents and treat any associated systemic diseases. Treatment is ultimately dependent on underlying etiology. While there are no randomized controlled clinical trials to assess treatment choice and efficacy in TIN, corticosteroids have been a mainstay of therapy and recent studies have suggested a possible role for mycophenolate mofetil. Urinary biomarkers such as alpha1-microglobulin and beta2-microglobulin may help diagnose and monitor disease activity in TIN. Screening for TIN should be implemented in children with inflammatory bowel disease, uveitis, or IgG4-associated MAD.

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“…Because TINU syndrome may be difficult to recognize and it is unknown to many ophthalmologists, it is probably under diagnosed. Undiagnosed TINU may account for a portion of the 54% of pediatric uveitis cases labeled as idiopathic [54].…”

Section: Tubulointerstitial Nephritis and Uveitis (Tinu) Syndromementioning

confidence: 99%

Review of Pediatric Uveitis

Groppi¹,

Kim²,

Goldstein³

2007

CPR

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Uveitis is a significant cause of blindness and vision loss in children and encompasses a diverse group of disease processes. It is important that physicians become familiar with presenting symptoms and signs of uveitis. Early recognition and referral to a uveitis specialist is key in preventing irreversible vision loss. Aggressive management with antiinflammatory medications and immunosuppressive agents may be necessary. This chapter will provide an introduction to common causes of pediatric uveitis, as well as a discussion of classification, etiologies, work-up, and management.

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Tubulointerstitial nephritis and uveitis syndrome: recognizing the importance of an uncommon disease

Cited by 15 publications

References 13 publications

Strong Associations between Specific HLA-DQ and HLA-DR Alleles and the Tubulointerstitial Nephritis and Uveitis Syndrome

Strong Associations between Specific HLA-DQ and HLA-DR Alleles and the Tubulointerstitial Nephritis and Uveitis Syndrome

Tubulointerstitial nephritis: diagnosis, treatment, and monitoring

Review of Pediatric Uveitis

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