Tucum-Do-Cerrado (Bactris setosa Mart.) Consumption Modulates Iron Homeostasis and Prevents Iron-Induced Oxidative Stress in the Rat Liver

Fustinoni-Reis, Adriana M.; Arruda, Sandra Fernandes; Dourado, Lívia P. S.; Cunha, Marcela de Sá Barreto da; Siqueira, Egle M. A.

doi:10.3390/nu8020038

Cited by 22 publications

(26 citation statements)

References 45 publications

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“…Interestingly, flavonoid glycosides, derived from apigenin, present in beet stalks and leaves may have acted as natural exogenous antioxidants, reducing or minimizing the oxidative stress in mice that were fed on a high-fat diet, similarly to the observations of other studies [ 40 , 41 , 42 ]. This effect may be due to the antioxidant activity of polyphenols present in fruits and vegetables, which may reduce the requirement for antioxidant enzymatic function by up-regulating Nrf 2-dependent antioxidant enzymes [ 43 ]. As a consequence, there was no alteration in the activities of antioxidant enzymes, such as GPx [ 43 ].…”

Section: Discussionmentioning

confidence: 99%

“…This effect may be due to the antioxidant activity of polyphenols present in fruits and vegetables, which may reduce the requirement for antioxidant enzymatic function by up-regulating Nrf 2-dependent antioxidant enzymes [ 43 ]. As a consequence, there was no alteration in the activities of antioxidant enzymes, such as GPx [ 43 ].…”

Section: Discussionmentioning

confidence: 99%

“…Similarly, Fustinoni-Reis et al (2016) observed that the high concentration of antioxidant compounds in tucum-do-cerrado fruit ( Bactris cetrosa Mart.) reduced intestinal GPx activity when oxidative stress was induced by an iron-supplemented diet [ 43 ]. Thus, when the organism is exposed to any adverse situation that generates a higher production of ROS, potential therapeutic health benefits can be observed as a function of the dose and time of the administration of vegetables containing bioactive compounds such as Vitexin-2- O -rhamnoside and Vitexin-2- O -xyloside, which are present in beet stalks and leaves [ 19 ].…”

Section: Discussionmentioning

confidence: 99%

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Beet Stalks and Leaves (Beta vulgaris L.) Protect Against High-Fat Diet-Induced Oxidative Damage in the Liver in Mice

et al. 2018

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Some flavonoids identified in beet stalks can help the antioxidant endogenous defenses during a chronic inflammation process. The current study investigates the effect of polyphenols present in beet stalks and leaves on liver oxidative damage in mice fed a high-fat diet (HF). The control (CT) or HF diet groups were supplemented with dehydrated beet stalks and leaves (SL) or beet stalk and leaf ethanolic extract (EX). In terms of Vitexin-rhaminoside equivalents (VRE), EX groups received ~5.91 mg of VRE·100 g−1 diet, while the SL groups received ~3.07 mg VRE·100 g−1 diet. After 8 weeks, we evaluated fasting blood glucose; cholesterol, hepatic Malondialdehyde (MDA) levels and hepatic Glutathione (GSH), Glutathione peroxidase (GPx), Glutathione reductase (GR) and Superoxide dismutase (SOD) activity. Dehydrated beet stalks and leaves (HFSL) attenuated the deleterious effects of a HF diet on lipid metabolism, reduced fasting blood glucose levels, ameliorated cholesterol levels and reduced GPx and GR activities (p < 0.05) compared to the HF group. However; the addition of ethanolic extract from beet stalks and leaves was unable (p > 0.05) to prevent the liver damage caused by HF diet in mice. The presence of flavonoids, such as Vitexin derivatives in beet stalks and leaves can help the liver damage induced by HF diet.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Beet Stalks and Leaves (Beta vulgaris L.) Protect Against High-Fat Diet-Induced Oxidative Damage in the Liver in Mice

et al. 2018

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“…Cerrado plant species are edible antioxidant-rich plants commonly found in Brazil. Among these species, the extract of the fruit of the tucum-do-cerrado plant (a fruit with a purple skin, whitish pulp, and a large seed) was shown to attenuate iron-induced increases in serum and tissue iron levels, transferrin saturation, and lipid oxidation (by increasing the expression of intestinal Nrf2 and hepatic hepcidin, ferritin, heme oxygenase 1 [Hmox1], NADPH dehydrogenase quinone 1 [Nqo1], Nrf2, and Bmp6), ultimately increasing the activity of antioxidant enzymes, including catalase, glutathione reductase, and GPx [ 82 ]. The authors found a general correlation between reduced oxidative damage and iron availability.…”

Section: Bioactive Compounds That Regulate Oxidative Stress and Irmentioning

confidence: 99%

Antioxidants Mediate Both Iron Homeostasis and Oxidative Stress

et al. 2017

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Oxidative stress is a common denominator in the pathogenesis of many chronic diseases. Therefore, antioxidants are often used to protect cells and tissues and reverse oxidative damage. It is well known that iron metabolism underlies the dynamic interplay between oxidative stress and antioxidants in many pathophysiological processes. Both iron deficiency and iron overload can affect redox state, and these conditions can be restored to physiological conditions using iron supplementation and iron chelation, respectively. Similarly, the addition of antioxidants to these treatment regimens has been suggested as a viable therapeutic approach for attenuating tissue damage induced by oxidative stress. Notably, many bioactive plant-derived compounds have been shown to regulate both iron metabolism and redox state, possibly through interactive mechanisms. This review summarizes our current understanding of these mechanisms and discusses compelling preclinical evidence that bioactive plant-derived compounds can be both safe and effective for managing both iron deficiency and iron overload conditions.

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“…Tucum-do-cerrado ( Bactris setosa Mart. ), a Brazilian savanna fruit, has a high content of different phytochemical compounds such as cyanidin-derivatives, epicatechin, catechin, piceatannol, quercetin, and all- trans -lutein, mainly found in the peel [ 25 , 27 ] and a high antioxidant potential in vitro and in vivo [ 28 , 29 , 30 ]; however, many other potential biological effects still need to be investigated. Therefore, we hypothesized that the dietary consumption of tucum-do-cerrado ( Bactris setosa Mart.…”

Section: Introductionmentioning

confidence: 99%

Tucum-do-Cerrado (Bactris setosa Mart.) May Promote Anti-Aging Effect by Upregulating SIRT1-Nrf2 Pathway and Attenuating Oxidative Stress and Inflammation

Cunha

Arruda

2017

Nutrients

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Aging may be related to oxidative damage accumulation and a low-grade inflammation, both responses are modulated by iron and phytochemicals. This study investigated the effect of tucum-do-cerrado (Bactris setosa Mart.) consumption on the expression of sirtuins (SIRT 1 and 3) and senescence marker protein-30 (SMP30), and on the redox and inflammatory responses, in adult rats supplemented or not with dietary iron. Male Wistar rats were treated for 12 weeks with: control diet (CT); iron enriched-diet (+Fe); control diet + 15% tucum-do-cerrado (Tuc); or iron enriched-diet + 15% tucum-do-cerrado (Tuc + Fe). Iron supplementation (+Fe) increased liver, spleen and intestine iron levels, transferrin saturation, serum iron, serum TNF-α and IL-6 levels, hepatic carbonyl content and and superoxide dismutase (SOD) activity, hepatic Nrf2 protein and Nqo1 mRNA levels and decreased the renal Sirt1 mRNA levels in relation to CT group. Tucum-do-cerrado consumption (Tuc) increased hepatic SOD activity, Nrf2 and SIRT1 mRNA and protein contents, and Nqo1 mRNA levels, while it decreased the renal SOD activity compared with the CT diet. The consumption of tucum-do-cerrado associated with the iron-enriched diet (Tuc + Fe) increased the iron levels in tissues and serum transferrin saturation, compared to the CT diet, while promoting a decrease in hepatic carbonyl and renal malondialdehyde levels, marginally reducing serum IL-6 levels, and increasing hepatic SIRT1 protein content, renal Sirt1 and hepatic Nrf2 mRNA levels, compared to the +Fe group. None of the treatments altered Smp30 mRNA levels. The results suggest that tucum-do-cerrado consumption might promote an anti-aging effect by increasing SIRT1 expression, which may enhance Nrf2 mRNA and protein levels and its downstream pathway, which in turn decrease oxidative damage to proteins and the levels of inflammatory cytokines (IL-6 and TNF-α), induced by iron excess.

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Tucum-Do-Cerrado (Bactris setosa Mart.) Consumption Modulates Iron Homeostasis and Prevents Iron-Induced Oxidative Stress in the Rat Liver

Cited by 22 publications

References 45 publications

Beet Stalks and Leaves (Beta vulgaris L.) Protect Against High-Fat Diet-Induced Oxidative Damage in the Liver in Mice

Beet Stalks and Leaves (Beta vulgaris L.) Protect Against High-Fat Diet-Induced Oxidative Damage in the Liver in Mice

Antioxidants Mediate Both Iron Homeostasis and Oxidative Stress

Tucum-do-Cerrado (Bactris setosa Mart.) May Promote Anti-Aging Effect by Upregulating SIRT1-Nrf2 Pathway and Attenuating Oxidative Stress and Inflammation

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