“…Only 19 cases have been reported to have the first lesions after the age of 50 years as in the present case [3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15]. The oldest age at onset was 84 [15].…”
Tufted angioma (angioblastoma) usually occurs in infancy. Some lesions reveal proliferation of eccrine glands and some undergo spontaneous regression. We report a lesion from the left lateral chest of a 58-year-old male, which had appeared 5 years ago and gradually increased in size. Its color had faded out centrally. Histological examination showed many angiomatous lobules on the border of the lesion but few in the central portion. Abundant eccrine sweat glands, small venules and dense connective tissue were seen in both areas. The histology and the clinical course suggested that central regression occurred in the lesion. Out of 211 reported cases, we found 4 cases that had annular lesions spreading centrifugally. Though these lesions were not examined histologically, they were suspected to regress in the central portions. We suggest that central regression can rarely occur in tufted angioma.
“…Only 19 cases have been reported to have the first lesions after the age of 50 years as in the present case [3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15]. The oldest age at onset was 84 [15].…”
Tufted angioma (angioblastoma) usually occurs in infancy. Some lesions reveal proliferation of eccrine glands and some undergo spontaneous regression. We report a lesion from the left lateral chest of a 58-year-old male, which had appeared 5 years ago and gradually increased in size. Its color had faded out centrally. Histological examination showed many angiomatous lobules on the border of the lesion but few in the central portion. Abundant eccrine sweat glands, small venules and dense connective tissue were seen in both areas. The histology and the clinical course suggested that central regression occurred in the lesion. Out of 211 reported cases, we found 4 cases that had annular lesions spreading centrifugally. Though these lesions were not examined histologically, they were suspected to regress in the central portions. We suggest that central regression can rarely occur in tufted angioma.
“…It can present as red or bluish to violaceous papule, plaque or nodule over neck, upper back and proximal part of limbs typically in childhood and infancy. These lesions may also develop in adults or the elderly [7]. There is no sex predilection [8].…”
Section: Discussionmentioning
confidence: 99%
“…Background is loose, mesenchymal with mononuclear inflammatory cell infiltrate and mast cells [13,14]. In adults, TA needs to be differentiated from Kaposi’s sarcoma and low grade angiosarcoma [2,7]. Endothelial cells in TA appear plump to slightly spindled and lack the spindling of Kaposi’s sarcoma [8].…”
Section: Discussionmentioning
confidence: 99%
“…Vascular spaces of TA are relatively bloodless when compared to blood filled spaces in Kaposi’s sarcoma. Lack of nuclear atypia excludes angiosarcoma [7]. Other diagnostic hints of angiosarcoma include presence of sinusoid like spaces, dissection of collagen, mitoses, necrosis and haemorrhage [8,15].…”
Tufted angioma, first recognized in Japanese literature as “Angioblastoma of Nagakawa”, is a rare benign vascular tumour with a variable clinical presentation. It commonly manifests as a macule, papule or nodule in infancy or childhood in the region of the upper trunk and neck. Here in we report two cases of this rare progressive angioma as lesions of the eyelid in adults. Tufted angioma has a classical “cannon ball” like appearance of vascular tufts on histopathology. Immunohistochemical staining with actin highlights the spindly stromal cells surrounding the capillaries. Complete physical examination and haematological work up is recommended in patients with tufted angioma to exclude rare association of port wine stain and Kasabach-Merritt syndrome with this rare entity. To the best of our knowledge, our cases illustrate the first case report of tufted angioma presenting as an eyelid lesion.Virtual SlidesThe virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1230909536950947.
“…144 There is no significant gender predilection. The lesions appear mainly on the neck, shoulders, and trunk, although other areas can be affected.…”
Abstract-Increased understanding of the mechanisms of angiogenesis and lymphangiogenesis has provided a glimpse at some of the molecules involved in the pathophysiology of hemangiomas and vascular malformations. This review focuses on recent advances in our understanding of the mechanisms of angiogenesis/lymphangiogenesis and the differentiation of arterial, venous, and lymphatic vessels. We integrate this knowledge with new data obtained from genetic studies in humans, which have revealed a number of heretofore-unsuspected candidates involved in the development of familial vascular anomalies. We present a common infantile vascular tumor, hemangioma, and then focus on hereditary familial vascular and lymphatic malformations. We also summarize transgenic mouse models for some of these malformations. It seems reasonable to believe that novel therapeutic strategies will soon emerge for the treatment of hemangiomas and vascular malformations.
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