Tumor acidity-activatable manganese phosphate nanoplatform for amplification of photodynamic cancer therapy and magnetic resonance imaging

Hao, Yongwei; Zheng, Cuixia; Wang, Lei; Zhang, Jinjie; Niu, Xiuxiu; Song, Qingling; Feng, Qianhua; Zhao, Hongjuan; Li, Li; Zhang, Hongling; Zhang, Zhenzhong; Zhang, Yun

doi:10.1016/j.actbio.2017.08.028

Cited by 40 publications

(33 citation statements)

References 55 publications

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“…Other manganese-basednanomaterials proposed as responsive CAs are phosphates. At least two different routes have been described for the preparation of nano-Mn phosphates:m icroemulsion and hydrothermal treatment.A ccording to Hao et al, [71] amorphous porous Mn x (PO 4 ) y can be obtained through the hydrothermalr eaction between Mn II acetylacetonate and triethylp hosphate in toluenei nt he presence of classic ligands oleic acid and oleylamine, and as mall volumeo fw ater (Figure 4B). In as tructurally relatedw ork, Mi et al [70] prepared calcium phosphate NPsa nd used them as ap latform to release Mn 2 + ions under lowp Hc onditions ( Figure 4A).…”

Section: Manganese Phosphatesmentioning

confidence: 71%

Recent Progress on Manganese‐Based Nanostructures as Responsive MRI Contrast Agents

García‐Hevia

Bañobre‐López

Gallo

2018

Chemistry A European J

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Manganese-based nanostructured contrast agents (CAs) entered the field of medical diagnosis through magnetic resonance imaging (MRI) some years ago. Although some of these Mn-based CAs behave as classic T contrast enhancers in the same way as clinical Gd-based molecules do, a new type of Mn nanomaterials have been developed to improve MRI sensitivity and potentially gather new functional information from tissues by using traditional T contrast enhanced MRI. These nanomaterials have been designed to respond to biological environments, mainly to pH and redox potential variations. In many cases, the differences in signal generation in these responsive Mn-based nanostructures come from intrinsic changes in the magnetic properties of Mn cations depending on their oxidation state. In other cases, no changes in the nature of Mn take place, but rather the nanomaterial as a whole responds to the change in the environment through different mechanisms, including changes in integrity and hydration state. This review focusses on the chemistry and MR performance of these responsive Mn-based nanomaterials.

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Section: Manganese Phosphatesmentioning

confidence: 71%

Recent Progress on Manganese‐Based Nanostructures as Responsive MRI Contrast Agents

García‐Hevia

Bañobre‐López

Gallo

2018

Chemistry A European J

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“…Interestingly, the amorphous porous manganese phosphate (MnP) nanoparticles may be suitable for their delivery due to its ultra pH-responsive property. [15] Importantly, this kind of nanomaterials were further demonstrated to be not fluorescence quencher in this study, and it should be a good candidate for delivering ICG and autophagy regulation agent for achieving multiple desirable therapeutic performances, especially for combating cancer.…”

Section: Introductionmentioning

confidence: 81%

“…Owing to the lower pH environment of endosomes/lysosomes, where extra nanoparticles usually pass through, the acid‐responsive release vehicle might satisfy the improved stability in circulation and quick release requirement after cellular uptake. Interestingly, the amorphous porous manganese phosphate (MnP) nanoparticles may be suitable for their delivery due to its ultra pH‐responsive property . Importantly, this kind of nanomaterials were further demonstrated to be not fluorescence quencher in this study, and it should be a good candidate for delivering ICG and autophagy regulation agent for achieving multiple desirable therapeutic performances, especially for combating cancer.…”

Section: Introductionmentioning

confidence: 90%

“…Synthesis of the amorphous porous manganese phosphate (MnP) nanoparticles : The MnP was obtained by following a literature procedure with a minor modification . Oleic acid (4 mL), oleylamine (6 mL) and methylbenzene (24 mL) were mixed in a stainless steel autoclave, then deionized water (0.4 mL), manganese (II) 2,4‐pentanedionate (2 mmol) and triethyl phosphate (0.8 mL) were added into the above reaction system.…”

Section: Methodsmentioning

confidence: 99%

“…The MnP was obtained by following a literature procedure with a minor modification. [15] Oleic acid (4 mL), oleylamine (6 mL) and methylbenzene (24 mL) were mixed in a stainless steel autoclave, then deionized water (0.4 mL), manganese (II) 2,4pentanedionate (2 mmol) and triethyl phosphate (0.8 mL) were added into the above reaction system. The autoclave was heated at 180°C for 9 h, and cooled down rapidly by washing with cold water, and then the anhydrous ethanol was purged into it.…”

Section: Synthesis Of the Amorphous Porous Manganese Phosphate (Mnp) mentioning

confidence: 99%

See 2 more Smart Citations

A Photo‐Stable Indocyanine Green and Rapamycin Co‐Delivery System Based on Poly(Glutamic Acid)‐Modified Manganese Phosphate for Synergetic Tumor Therapy

et al. 2019

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Some manganese‐based nanomaterials quench the fluorescence of photosensitizers, which strongly quenches fluorescence emission and suppresses reactive oxygen species (ROS) production due to the photo‐induced charge transfer from the excited photosensitizer to nanomaterials. In this study, to overcome these disadvantages, amorphous porous manganese phosphate (MnP) nanoparticles are used for loading indocyanine green (ICG), and a broader ICG absorbance width instead of weakened fluorescence profile is observed, resulting in higher stability and phototherapy efficiency under 808 nm irradiation. Moreover, autophagy inhibition obviously weakens the ICG‐mediated phototherapy to breast cancer cells. On this foundation, an autophagy promoter rapamycin (RAPA) and ICG are co‐loaded into the MnP nanoparticles, and further decorated with biocompatible poly(glutamic acid). As expected, this stable nanoplatform released 80.0±4.1% agents at low pH compared to that 32.0±4.8% at normal pH, indicating a clear pH‐responsive release profile. Uniting phototherapy with autophagy promoter by this system is found to achieve synergistic outcomes as evidenced by the smaller relative tumor volume of 1.8±0.4. Overall, this work provides the first photo‐stable manganese‐based nanomaterial without fluorescence quenching profile for achieving multiple desirable therapeutic performances.

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Tumor Diagnosis and Therapy Mediated by Metal Phosphorus‐Based Nanomaterials

et al. 2021

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to their unique physical and chemical properties. [2] Therefore, to improve the efficacy of early diagnosis and cure rate, many types of inorganic nanomaterials have been prepared for tumor therapy, such as elemental substances (Au, Ag, Pt, etc.), [3a-c] chemical compounds (carbon-, silic-, nitrogen-, phosphorus-based nanomaterials, etc), [3d-f ] metal organic frameworks, and so on. [3g,h] Among above inorganic nanoterials, phosphorus-based nanomaterials have broad application prospects in the field of biomedicine because phosphorus is one of the crucial component elements in our body and it could maintain vital activities in different aspects: [4] 1) Phosphorus is one of the basic elements in protein and phospholipid and it is necessary to maintain the integrity of cell membranes and perform cell functions. 2) Phosphorus is also a necessary component of phosphate in body fluids and it could regulate the pH balance and energy metabolism. 3) Phosphorus is one of the basic elements of our bone for supporting our body. Among the phosphorus-based nanomaterials, metal phosphorus-based nanomaterials (Metal-P NMs) have been widely explored and studied in cancer diagnosis and therapy due to their unique merits, such as excellent optical absorption, inherent magnetic properties, and biodegradable properties.Metal-P NMs mainly include metal phosphide nanomaterials (e.g., ferrous phosphide (Fe 2 P), [5] iron phosphide (FeP), [6] cuprous phosphide (Cu 3 P), [7] trinickel monophosphide (Ni 3 P), [8] dicobalt phosphide (Co 2 P), [9a-c] cobalt phosphides (CoP), [9d,e] cadmium phosphide (Cd 3 P 2 ), [10] and indium phosphide (InP) [11] ), metal phosphate nanomaterials (e.g., calcium phosphate (CaP), [12] calcium bisphosphonate (CaBP), [13] manganese phosphate (MnP), [14,50] zirconium phosphate (ZrP), [15] magnesium phosphate (MgP), [16] gadolinium phosphate (GdPO 4 ), [17] and copper hydroxyphosphate (Cu 2 (OH)PO 4 ) [18] ), and metalblack phosphorus (Metal-BP) nanocomposite. [19] The excellent optical, magnetic, and catalytic properties make Metal-P NMs can be used as multifunctional diagnostic (photoacoustic imaging (PAI), fluorescent imaging (FI), magnetic resonance imaging (MRI), and nuclear imaging) and therapeutic (photothermal therapy (PTT), chemodynamic therapy (CDT), photodynamic therapy (PDT), and immunotherapy) agents for tumor theranostics. [5][6][7][8][9][10][11][12][13][14][15][16][17][18][19] Moreover, Metal-P NMs are also suitable to Metal phosphorus-based nanomaterials (Metal-P NMs) including metal phosphate nanomaterials, metal phosphide nanomaterials, and metal-black phosphorus (Metal-BP) nanocomposite are widely used in the field of biomedicine owing to their excellent physical and chemical properties, biocompatibility, and biodegradability. In recent years, metal phosphate nanomaterials and Metal-BP nanocomposite acted as medicine delivery system have made breakthroughs in tumor diagnosis including magnetic resonance imaging, fluorescence imaging, photoacoustic imaging, nuclear imaging, and therapies ...

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Tumor acidity-activatable manganese phosphate nanoplatform for amplification of photodynamic cancer therapy and magnetic resonance imaging

Cited by 40 publications

References 55 publications

Recent Progress on Manganese‐Based Nanostructures as Responsive MRI Contrast Agents

Recent Progress on Manganese‐Based Nanostructures as Responsive MRI Contrast Agents

A Photo‐Stable Indocyanine Green and Rapamycin Co‐Delivery System Based on Poly(Glutamic Acid)‐Modified Manganese Phosphate for Synergetic Tumor Therapy

Tumor Diagnosis and Therapy Mediated by Metal Phosphorus‐Based Nanomaterials

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