Tumor-activated targetable photothermal chemotherapy using IR780/zoledronic acid-containing hybrid polymeric nanoassemblies with folate modification to treat aggressive breast cancer

Liu, Yu-Ling; Wang, Tzu-Hao; Yeh, Nien-Tzu; Huang, Wei-Jen; Tzang, Bor-Show; Wu, I-Ting; Chin, Hao-Yang; Hu, Shang-Hsiu; Hsu, Tsai-Ching; Chiang, Wen-Hsuan

doi:10.1039/d3nr05637f

Cited by 3 publications

(1 citation statement)

References 55 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In recent years, folate-modified nanocarriers have shown enhanced cellular uptake through FR-mediated endocytosis with remarkable targeting efficiency. For example, folate-modified hybrid polymeric nanoassemblies were developed for tumor-targeted codelivery of IR780 (a lipophilic photothermal reagent) and zoledronic acid (a hydrophilic chemotherapy drug) . The uptake of a folate-modified nanosystem was remarkably promoted by folate receptor-overexpressed 4T1 breast cancer cells through FR-mediated endocytosis and thus effectively hindered the migration of cancer cells and augmented the anticancer efficacy of photothermal chemotherapy.…”

Section: Introductionmentioning

confidence: 99%

Folate-Modified pH and ROS Dual-Responsive Polymeric Nanocarriers for Targeted Anticancer Drug Delivery

Dai,

Chen,

Zhang

et al. 2024

ACS Appl. Nano Mater.

View full text Add to dashboard Cite

The tumor microenvironment is distinguished from normal tissues, such as the acidic microenvironment, elevated reactive oxygen species (ROS) levels, and overexpressed specific receptors on the cell surface. According to these unique hallmarks of cancer, stimulus-responsive drug carriers can be designed for targeted anticancer drug delivery and specific drug release in tumor tissues. Herein, a folate-modified pH/ROS dual-responsive polymeric micellar nanosystem was developed for the targeted delivery of doxorubicin (DOX). The drug release profile suggested a sustained drug release from the polymeric micelles and an accelerated drug release at lower pH and higher ROS levels. The cellular uptake assay indicated that the polymeric micelles were internalized by HepG2 cells and that the cellular uptake of micelles can be enhanced by folate modification through a receptor-mediated endocytosis pathway. Furthermore, the folate-modified pH/ ROS dual-responsive polymeric micellar nanocarriers demonstrated enhanced inhibition on the migration of HepG2 cells in the cell scratch test and showed improved suppression on the proliferation of HepG2 cells and a lower IC 50 than the nonfolate micelles in the cell viability test, indicating the desirable in vitro anticancer efficiency of the nanosystem.

show abstract

Section: Introductionmentioning

confidence: 99%

Folate-Modified pH and ROS Dual-Responsive Polymeric Nanocarriers for Targeted Anticancer Drug Delivery

Dai,

Chen,

Zhang

et al. 2024

ACS Appl. Nano Mater.

View full text Add to dashboard Cite

show abstract

PEGylated chitosan-coated nanophotosensitizers for effective cancer treatment by photothermal-photodynamic therapy combined with glutathione depletion

Chen,

Liu,

Lin

et al. 2024

International Journal of Biological Macromolecules

View full text Add to dashboard Cite

Hyaluronic acid-covered ferric ion-rich nanobullets with high zoledronic acid payload for breast tumor-targeted chemo/chemodynamic therapy

Yeh,

Lin,

Liu

et al. 2024

International Journal of Biological Macromolecules

View full text Add to dashboard Cite

Tumor-activated targetable photothermal chemotherapy using IR780/zoledronic acid-containing hybrid polymeric nanoassemblies with folate modification to treat aggressive breast cancer

Abstract: To effectively treat aggressive breast cancer by tumor-activated targetable photothermal-chemotherapy, in this work, the folate (FA)-modified hybrid polymeric nanoassemblies (HPNs) equipped with poly(ethylene glycol) (PEG)-detachable capability are developed as vehicles...

Cited by 3 publications

References 55 publications

Folate-Modified pH and ROS Dual-Responsive Polymeric Nanocarriers for Targeted Anticancer Drug Delivery

Folate-Modified pH and ROS Dual-Responsive Polymeric Nanocarriers for Targeted Anticancer Drug Delivery

PEGylated chitosan-coated nanophotosensitizers for effective cancer treatment by photothermal-photodynamic therapy combined with glutathione depletion

Hyaluronic acid-covered ferric ion-rich nanobullets with high zoledronic acid payload for breast tumor-targeted chemo/chemodynamic therapy

Contact Info

Product

Resources

About