Tumor-associated macrophages correlate with the clinicopathological features and poor outcomes via inducing epithelial to mesenchymal transition in oral squamous cell carcinoma

Hu, Yong; He, Ming; Zhu, Lingjun; Yang, Chengzhe; Zhou, Meiling; Wang, Qiong; Zhang, Wei; Zheng, Yujie; Wang, Dongmiao; Xu, Zeng-Qi; Wu, Yunong; Liu, Laikui

doi:10.1186/s13046-015-0281-z

Cited by 155 publications

(130 citation statements)

References 32 publications

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“…Interestingly, we also found that the number of double positive in the stroma CD68+ CD163+, commonly identified as pro‐tumor macrophages, was negatively correlated with expression of HLA‐DP/DQ/DR on tumor cells (Spearman r = −0.45 and P < .0001). The median value of the number of CD68+ CD163+ cells was used to identify samples with high or low number of CD68+ CD163+ cells in the stromal compartment.…”

Section: Resultsmentioning

confidence: 64%

HLA class II expression on tumor cells and low numbers of tumor‐associated macrophages predict clinical outcome in oropharyngeal cancer

et al. 2018

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Background Human papillomavirus (HPV)‐positive oropharyngeal squamous cell carcinoma (OPSCC) is a highly immunogenic tumor and differences in tumor microenvironment might contribute to the improved survival of HPV‐positive OPSCC patient. Methods A comprehensive multivariate analysis with clinical and immune variables (human leukocyte antigen [HLA] I/II, programmed death ligand 1 (PD‐L1), programmed death receptor 1 (PD1), T cells, and macrophages) was performed in 142 OPSCC patients. Results We found an inverse correlation between the expression of HLA class II molecules on tumor cells and CD68+ CD163+ tumor‐associated macrophages (TAMs). High HLA‐DP/DQ/DR expression and low number of TAMs were associated with longer disease‐specific survival and disease‐free survival (DFS). Furthermore, a new population of CD8+ FoxP3+ T cells was correlated with shorter DFS in multivariate analysis. Conclusions \We identified new prognostic markers for patients with oropharyngeal cancer, which can be used for selecting patients that can benefit from immunotherapy.

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Section: Resultsmentioning

confidence: 64%

HLA class II expression on tumor cells and low numbers of tumor‐associated macrophages predict clinical outcome in oropharyngeal cancer

et al. 2018

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“…In that study, high intratumoral CD163 expression was found to be correlated with E‐cadherin loss (Yan et al ., ). Global density of macrophages also relates to EMT features in non‐small‐cell lung cancer carcinoma (NSCLC) (Bonde et al ., ) or head and neck cancer (Hu et al ., ).…”

Section: Emt and The Cellular Actors Of Inflammationmentioning

confidence: 97%

EMT and inflammation: inseparable actors of cancer progression

et al. 2017

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Tumors can be depicted as wounds that never heal, and are infiltrated by a large array of inflammatory and immune cells. Tumor‐associated chronic inflammation is a hallmark of cancer that fosters progression to a metastatic stage, as has been extensively reviewed lately. Indeed, inflammatory cells persisting in the tumor establish a cross‐talk with tumor cells that may result in a phenotype switch into tumor‐supporting cells. This has been particularly well described for macrophages and is referred to as tumor‐associated ‘M2’ polarization. Epithelial‐to‐mesenchymal transition (EMT), the embryonic program that loosens cell–cell adherence complexes and endows cells with enhanced migratory and invasive properties, can be co‐opted by cancer cells during metastatic progression. Cancer cells that have undergone EMT are more aggressive, displaying increased invasiveness, stem‐like features, and resistance to apoptosis. EMT programs can also stimulate the production of proinflammatory factors by cancer cells. Conversely, inflammation is a potent inducer of EMT in tumors. Therefore, the two phenomena may sustain each other, in an alliance for metastasis. This is the focus of this review, where the interconnections between EMT programs and cellular and molecular actors of inflammation are described. We also recapitulate data linking the EMT/inflammation axis to metastasis.

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“…High proportions of TAMs in oral cancer predicted poor clinical outcome (8), perhaps through TAM-induced cancer cell EMT (25), which would facilitate invasive growth and increase metastatic potential. Although we examined TAM density in disease recurrence and not patient survival, macrophage density at the infiltrative front was not prognostically significant.…”

Section: Stromal Cells (Red Arrows) At the Invasive Front Of Carcinmentioning

confidence: 99%

Low Mast Cell Density Predicts Poor Prognosis in Oral Squamous Cell Carcinoma and Reduces Survival in Head and Neck Squamous Cell Carcinoma

Attramadal

Kumar

Gao

et al. 2016

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Abstract. Background: The cellular composition of the tumor microenvironment (TME) at the invading front of oral squamous cell carcinomas (OSCCsThe growth of oral squamous cell carcinoma cells is influenced by its stroma. Stromal cells such as mast cells (MCs), cancer-associated fibroblasts (CAFs), tumorassociated macrophages (TAMs), endothelial cells, pericytes, smooth muscle cells and lymphocytes promote tumor growth, local infiltration, proliferation, neovascularization and escape from immune defense (1). Such cancer-amended stroma is referred to as the tumor microenvironment (TME) (2), and is probably as important as the cancer itself in facilitating cancer cell invasion and metastasis. In the current study of early-stage oral squamous cell carcinomas (OSCCs), we examined the significance of MCs, CAFs, TAMs and endothelial cells in the TME of the invasive front, and their influence on disease recurrence. The MC findings were further explored in a larger cohort of patients with head and neck squamous cell carcinoma.MCs are especially present in surface mucosa such as the skin, bronchial tract, lungs and digestive tract, conjunctiva, nose and mouth, and are best known for their role in allergic immune reactions (3). The TME in OSCC contains more MCs than normal oral mucosa (4), but their role in TME is intricate and poorly understood. These MCs may promote cancer growth by stimulating angiogenesis and tissue remodeling, but also exert anticancerous effects, depending on cofactors and cell location (5).CAFs represent a common functional state of cancerstimulated mesenchymal cells. Their cell of origin is 5499

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Tumor-associated macrophages correlate with the clinicopathological features and poor outcomes via inducing epithelial to mesenchymal transition in oral squamous cell carcinoma

Cited by 155 publications

References 32 publications

HLA class II expression on tumor cells and low numbers of tumor‐associated macrophages predict clinical outcome in oropharyngeal cancer

HLA class II expression on tumor cells and low numbers of tumor‐associated macrophages predict clinical outcome in oropharyngeal cancer

EMT and inflammation: inseparable actors of cancer progression

Low Mast Cell Density Predicts Poor Prognosis in Oral Squamous Cell Carcinoma and Reduces Survival in Head and Neck Squamous Cell Carcinoma

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