Tumor-Associated Tissue Eosinophilia in Squamous Cell Carcinoma of Head and Neck

Abstract

Background: Tumor-associated tissue eosinophilia (TATE) is reported in different cancers of human body but its exact role is not yet defined in head and neck squamous cell carcinoma (HNSCC). Objectives: The current study aimed to assess the relationship between TATE and histopathologic grading, age and gender of patients with HNSCC. Materials and Methods:In this cross-sectional study, 90 paraffin-embedded blocks of HNSCC samples were sectioned and stained with Sirius red (a histochemical staining). Then the eosinophils were counted in 10 high power fields with magnification of 400x (eosinophil/10HPF). Data were analyzed using Mann-Whitney, Kruskal-Wallis and the Spearman correlation tests by SPSS software version 21.0. Results: The mean age of the samples was 60.23 years, 46.67% of the samples were male and 53.33% were female. Histopathologically, 51 cases were grade1 (56.67%), 25 cases were grade 2 (27.78%) and 14 cases were grade 3 (15.55%). The average eosinophil count in all

Traumatic Ulcerative Granuloma with Stromal Eosinophilia (TUGSE)-A Precursor of Oral Squamous Cell Carcinoma?

“…2 A retrospective review by Hirshberg et al 7 suggested that the lesion is self-healing with the duration ranging from several weeks to one year. Observations by Rahrotaban et al 8 revealed the anti-tumour role of eosinophils with a positive correlation between the degree of tumour differentiation and tumourassociated tissue eosinophilia (poorly differentiated tumours had lesser tissue eosinophilia). Bankur et al 9 performed a quantitative study on tumour-associated tissue eosinophils with various histological grades of oral squamous cell carcinoma and suggested that tissue eosinophilia is higher in well-differentiated squamous cell carcinoma compared to other grades.…”

Eosinophil Density in Common Benign and Malignant Salivary Gland Tumors with Congo Red Staining

“…Some researchers consider eosinophils as the cause of tumor progression and poor disease prognosis, and some believe that they contribute to a favorable prognosis and a high survival in patients. [8,9] Many studies have examined their density in oral squamous cell carcinoma, [10] but few have assessed their density and arrangement in salivary gland tumors, and none have compared their density in common benign and malignant salivary gland tumors. The present study was therefore conducted to examine this issue and investigate the relationship between eosinophil density and the degree of malignancy in malignant salivary gland tumors.…”