Tumor Atelectasis Gives Rise to a Solid Appearance in Pulmonary Adenocarcinomas on High-Resolution Computed Tomography

Ambrosi, Francesca; Lissenberg‐Witte, Birgit I.; Comans, Emile F.I.; Sprengers, Ralf W.; Dickhoff, Chris; Radonic, Teodora; Thunnissen, Erik

doi:10.1016/j.jtocrr.2020.100018

Cited by 2 publications

(1 citation statement)

References 40 publications

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“…During inhalation the expansion of the tumor containing lung is slightly reduced, possibly more in the center of the tumor than in the periphery, which may lead to further reduction of air and a white appearance on CT, also called "tumor atelectasis." 30 According to older studies, the absence or the presence of only a small number of solid regions within the nodule on CT generally indicates the absence of invasive growth. 31 In more recent studies, this perception gets blurred.…”

Section: Ais and Radiologymentioning

confidence: 99%

Morphologic Features of Invasion in Lung Adenocarcinoma: Diagnostic Pitfalls

Thunnissen,

Noguchi,

Berezowska

et al. 2024

Advances in Anatomic Pathology

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Reproducibility of pulmonary invasive adenocarcinoma diagnosis is poor when applying the World Health Organization (WHO) classification. In this article, we aimed first to explain by 3-dimensional morphology why simple pattern recognition induces pitfalls for the assessment of invasion as applied in the current WHO classification of pulmonary adenocarcinomas. The underlying iatrogenic-induced morphologic alterations in collapsed adenocarcinoma in situ overlap with criteria for invasive adenocarcinoma. Pitfalls in seemingly acinar and papillary carcinoma are addressed with additional cytokeratin 7 and elastin stains. In addition, we provide more stringent criteria for a better reproducible and likely generalizable classification.

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Section: Ais and Radiologymentioning

confidence: 99%

Morphologic Features of Invasion in Lung Adenocarcinoma: Diagnostic Pitfalls

Thunnissen,

Noguchi,

Berezowska

et al. 2024

Advances in Anatomic Pathology

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Elastin in pulmonary pathology: relevance in tumours with a lepidic or papillary appearance. A comprehensive understanding from a morphological viewpoint

et al. 2021

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Elastin and collagen are the main components of the lung connective tissue network, and together provide the lung with elasticity and tensile strength. In pulmonary pathology, elastin staining is used to variable extents in different countries. These uses include evaluation of the pleura in staging, and the distinction of invasion from collapse of alveoli after surgery (iatrogenic collapse). In the latter, elastin staining is used to highlight distorted but pre‐existing alveolar architecture from true invasion. In addition to variable levels of use and experience, the interpretation of elastin staining in some adenocarcinomas leads to interpretative differences between collapsed lepidic patterns and true papillary patterns. This review aims to summarise the existing data on the use of elastin staining in pulmonary pathology, on the basis of literature data and morphological characteristics. The effect of iatrogenic collapse and the interpretation of elastin staining in pulmonary adenocarcinomas is discussed in detail, especially for the distinction between lepidic patterns and papillary carcinoma.

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Tumor Atelectasis Gives Rise to a Solid Appearance in Pulmonary Adenocarcinomas on High-Resolution Computed Tomography

Cited by 2 publications

References 40 publications

Morphologic Features of Invasion in Lung Adenocarcinoma: Diagnostic Pitfalls

Morphologic Features of Invasion in Lung Adenocarcinoma: Diagnostic Pitfalls

Elastin in pulmonary pathology: relevance in tumours with a lepidic or papillary appearance. A comprehensive understanding from a morphological viewpoint

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