2017
DOI: 10.1186/s41021-016-0069-1
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Tumor-augmenting effects of gestational arsenic exposure on F1 and F2 in mice

Abstract: The consequences of early-life exposure to chemicals in the environment are emerging concerns. Chronic exposure to naturally occurring inorganic arsenic has been known to cause various adverse health effects, including cancers, in humans. On the other hand, animal studies by Dr. M. Waalkes’ group reported that arsenite exposure of pregnant F0 females, only from gestational day 8 to 18, increased hepatic tumors in the F1 (arsenite-F1) males of C3H mice, whose males tend to develop spontaneous hepatic tumors lat… Show more

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Cited by 15 publications
(8 citation statements)
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“…Investigation of F1 generation of pups after exposure in dams is relevant because arsenic freely crosses the placenta and fetal blood barrier and can have permanent neurotoxic effects in offspring in later life [42,43,44,45]. It was reported that arsenite exposure of pregnant F0 females, only from gestational day 8 to 18, increased hepatic tumors in the F1 males of C3H mice [32,33,46]. In the present study, we exposed pregnant mice to 85 ppm NaAsO 2 from GD 8 to 18.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Investigation of F1 generation of pups after exposure in dams is relevant because arsenic freely crosses the placenta and fetal blood barrier and can have permanent neurotoxic effects in offspring in later life [42,43,44,45]. It was reported that arsenite exposure of pregnant F0 females, only from gestational day 8 to 18, increased hepatic tumors in the F1 males of C3H mice [32,33,46]. In the present study, we exposed pregnant mice to 85 ppm NaAsO 2 from GD 8 to 18.…”
Section: Discussionmentioning
confidence: 99%
“…The weight of water bottle for each mouse was measured before and after providing ad libitum access to water. The reasons for selection of a 85 ppm dose of NaAsO 2 are: (1) species differences were observed between human and mouse and a high dose is required for detection of neurotoxic effects in C3H mice and no maternal toxicity and teratogenicity were observed at the dose of present study; (2) this is a standard dose to detect the effects of developmental exposure to arsenic on neurotoxicity, reproductive toxicity and carcinogenicity in our research group [22,32,33]. The F1 male pups were weaned at postnatal day 21 and were randomly selected from different dams and housed under the same condition as the dams ( n = 3 per cage).…”
Section: Methodsmentioning
confidence: 99%
“…Mouse models have 63 been used to study the carcinogenic effects of arsenic exposure in utero at high levels 64 (42.5 and 85 ppm) (Waalkes et al 2007;Tokar et al 2012). Using the same 65 experimental model, Nohara et al (2017) found that in utero arsenic exposure 66 increased hepatic tumors in the F1 and F2 male offspring. Although this paradigm has 67 been used to study arsenic-related obesity in female offspring of CD-1 mice 68 (Rodriguez et al 2016), the reproductive effects of in utero arsenic exposure on 69 subsequent generations remain unclear.…”
mentioning
confidence: 95%
“…Nohara et al studied the tumor-augmenting effect of arsenic on liver cells in a similar study design. They showed that tumor-augmenting effect occurred in both F1 and F2 mice by maternal arsenic exposure [ 9 ].…”
Section: Introductionmentioning
confidence: 99%