Tumor bed effect of ionizing irrandiation in experimental cancer of the colon

O’Brien, Paul H.; Sweitzer, Caesar; Sherman, Joseph; Moss, William T.

doi:10.1002/1097-0142(196902)23:2<451::aid-cncr2820230220>3.0.co;2-9

Cited by 6 publications

(2 citation statements)

References 12 publications

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“…As reported by others groups and observed in the present study, the growth of subcutaneous tumours in pre-irradiated sites was reduced relative to tumours growing in non-irradiated sites, a phenomenon called the tumour bed effect (TBE) (O'Brien et al 1969). A visual evaluation would support such reduction of tumour growth, which was accompanied by the development of a necrotic centre in the tumours.…”

Section: Discussionmentioning

confidence: 99%

Irradiation of normal mouse tissue increases the invasiveness of mammary cancer cells

Lemay

Archambault

Tremblay

et al. 2011

International Journal of Radiation Biology

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Section: Discussionmentioning

confidence: 99%

Irradiation of normal mouse tissue increases the invasiveness of mammary cancer cells

Lemay

Archambault

Tremblay

et al. 2011

International Journal of Radiation Biology

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“…In early radiation experiments, it was noted that transplantable tumors had retarded growth when implanted into radiated tissues, and this observation was largely attributed to the disruption of capillary networks by radiation [19]. Damage to the microvasculature is a possible alternative or complementary hypothesis to the view that radiation-based tissue damage primarily targets the stem, or mesenchymal compartment of tissue.…”

Section: Principles Of Radiation Oncologymentioning

confidence: 99%

Combining Bevacizumab with Radiation or Chemoradiation for Solid Tumors: A Review of the Scientific Rationale, and Clinical Trials

Schmidt¹,

Lee²,

Ryeom³

et al. 2012

CAG

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Radiation therapy or the combination of radiation and chemotherapy is an important component in the local control of many tumor types including glioblastoma, rectal cancer, and pancreatic cancer. The addition of anti-angiogenic agents to chemotherapy is now standard treatment for a variety of metastatic cancers including colorectal cancer and non-squamous cell lung cancer. Anti-angiogenic agents can increase the efficacy of radiation or chemoradiation for primary tumors through mechanisms such as vascular normalization and augmentation of endothelial cell injury. The most commonly used anti-angiogenic drug, bevacizumab, is a humanized monoclonal antibody that binds and neutralizes vascular endothelial growth factor A (VEGF-A). Dozens of preclinical studies nearly uniformly demonstrate that inhibition of VEGF-A or its receptors potentiates the effects of radiation therapy against solid tumors, and this potentiation is generally independent of the type or schedule of radiation and timing of VEGF-A inhibitor delivery. There are now several clinical trials combining bevacizumab with radiation or chemoradiation for the local control of various primary, recurrent, and metastatic tumors, and many of these early trials show encouraging results. Some added toxicities occur with the delivery of bevacizumab but common toxicities such as hypertension and proteinuria are generally easily managed while severe toxicities are rare. In the future, bevacizumab and other anti-angiogenic agents may become common additions to radiation and chemoradiation regimens for tumors that are difficult to locally control.

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Effect of leukopenia and leukocytosis on tumor growth and survival time.Part I. Leukopenia

Scott

Matthews

Henrick

1970

Cancer

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The study was performed with 174 rabbits to determine the effect of leukophoresis and the resulting leukopenia on tumor transplant, growth, and survival time using the V2 carcinoma in the rabbit. Definite inhibition of tumor growth, together with increase in survival time, was found when leukophoresis was performed 7‐28 days after transplant as evidenced by an increase in survival time of 314 days in the entire group receiving 2 leukophoreses following transplants and 347 days in subgroups of those receiving 3 leukophoreses following transplants (but on days 7‐14‐21 or 14‐21‐28) vs. 73 days for the controls. The tumor growth rate paralleled the survival time and following transplant and leukophoresis, the increase and decrease of leukocytes paralleled the rate of tumor growth and retardation, respectively. There is reason to believe that the granulocyte may be more implicated than lymphocyte in tumor inhibition and survival time although so far experimental evidence has been on the side of the latter. A chance observation that leukophoretic plasma injected into cancerous and noncancerous animals produced marked leukocytosis, indicating a leukocytosis‐inducing factor, will serve to investigate any significant effects of leukocytosis on tumor growth and survival time and any possible interrelationship of leukopenia/leukocytosis to tumor inhibition and immunosuppression in Part II of this paper.

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Tumor bed effect of ionizing irrandiation in experimental cancer of the colon

Cited by 6 publications

References 12 publications

Irradiation of normal mouse tissue increases the invasiveness of mammary cancer cells

Irradiation of normal mouse tissue increases the invasiveness of mammary cancer cells

Combining Bevacizumab with Radiation or Chemoradiation for Solid Tumors: A Review of the Scientific Rationale, and Clinical Trials

Effect of leukopenia and leukocytosis on tumor growth and survival time.Part I. Leukopenia

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