The variation in the reported rates of KCS can be attributed to factors such as: limited sample size, age of patients sampled, gender, subjective versus objective determination of DED. The association between RA and KCS is well established and contributes to morbidity [4][5][6]. Features and pathogenesisSymptoms of KCS include: burning, gritty sensation and dryness. A recent meta-analysis demonstrated a link between dry eye disease and depression and anxiety [7]. If left untreated, KCS may lead to a lidwiper epitheliopathy (analogous to that found in long-term contact lens wearer), keratitis, and possibly even opacification of the cornea [8]. In severe cases, one can see paracentral corneal melts which can cause permanent visual loss, and even perforation.Inflammation has been postulated as the underlying cause for KCS [9]. The pathogenesis of RA involves an inappropriate attack on the

No abstract

The successful management of Kaposi's sarcoma with a systemic chemotherapeutic agent, Vincaleucoblastine, is presented. All patients, including the initial case treated in 1961, are presently free from disease. This method of treatment could be of considerable value in Central Africa, where the incidence is greater and facilities for radiotherapy and perfusion less.

The study was performed with 174 rabbits to determine the effect of leukophoresis and the resulting leukopenia on tumor transplant, growth, and survival time using the V2 carcinoma in the rabbit. Definite inhibition of tumor growth, together with increase in survival time, was found when leukophoresis was performed 7‐28 days after transplant as evidenced by an increase in survival time of 314 days in the entire group receiving 2 leukophoreses following transplants and 347 days in subgroups of those receiving 3 leukophoreses following transplants (but on days 7‐14‐21 or 14‐21‐28) vs. 73 days for the controls. The tumor growth rate paralleled the survival time and following transplant and leukophoresis, the increase and decrease of leukocytes paralleled the rate of tumor growth and retardation, respectively. There is reason to believe that the granulocyte may be more implicated than lymphocyte in tumor inhibition and survival time although so far experimental evidence has been on the side of the latter. A chance observation that leukophoretic plasma injected into cancerous and noncancerous animals produced marked leukocytosis, indicating a leukocytosis‐inducing factor, will serve to investigate any significant effects of leukocytosis on tumor growth and survival time and any possible interrelationship of leukopenia/leukocytosis to tumor inhibition and immunosuppression in Part II of this paper.

Some pentacyclic structures have been prepared from the 2-hydroxymethylene derivatives of steroidal 3-ketones by condensation with methyl vinyl ketone.