Tumor budding as a prognostic marker in laryngeal carcinoma

Sarıoğlu, Sülen; Acara, Ahmet Çağdaş; Akman, Fadime; Dag, Nihal; Ecevit, Cenk; İkiz, Ahmet Ömer; Çetinayak, Oğuz; Ada, Emel

doi:10.1016/j.prp.2009.09.006

Cited by 63 publications

(81 citation statements)

References 21 publications

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“…On multivariate analysis high intensity tumour budding had no statistically significant association with positive lymph nodes or prognosis (p = 0.49) unlike in the previous studies [9][10][11][12][13]. The reason for this finding may be because the presence of tumor budding (i.e.…”

Section: Role Of Tumor Budding In Gbcscccontrasting

confidence: 63%

“…After selecting a field in which maximum budding intensity was observed the number of foci was counted. Using 10 foci as cutoff value [12] tumor budding was divided into two groups; group 1 included low intensity budding (0-10 foci) and group 2 included high intensity budding ([10 foci); Fig. 2c.…”

Section: Histopathological Evaluationmentioning

confidence: 99%

“…Another advantage is it can be easily adapted to routine hematoxylin-eosin (H&E) staining based histopathological examination without the need for additional expensive techniques. High intensity Tumor budding has been recognized as an adverse prognostic factor in several human cancers like colorectal, oesophageal, laryngeal cancers and more recently tongue cancers [9][10][11][12][13]. However, little is known about the role of Tumor budding in GBCSCC.…”

Section: Role Of Tumor Budding In Gbcsccmentioning

confidence: 99%

“…Tumor budding is another histopathological parameter, that has been recognized as an adverse prognostic factor in several human cancers like colorectal, oesophageal, laryngeal cancers and more recently tongue cancers [9][10][11][12][13][14]. It is defined as presence of isolated single cells or small cell clusters scattered in the stroma ahead of the ITF and is characteristic of aggressive cancer.…”

Section: Introductionmentioning

confidence: 99%

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Prognostic and Predictive Factors in Gingivo Buccal Complex Squamous Cell Carcinoma: Role of Tumor Budding and Pattern of Invasion

Manjula

Augustine

Selvam³

et al. 2014

Indian J Otolaryngol Head Neck Surg

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Invasive tumor front (ITF) is the deepest three to six cell layers or detached tumor cell groups at the advancing edge of the tumor. Tumor budding is defined as presence of isolated single cells or small cell clusters scattered in the stroma ahead of the ITF and is characteristic of aggressive cancer. It is recognized as an adverse prognostic factor in several human cancers like colorectal, oesophageal, laryngeal cancers and more recently tongue cancers. However, the prognostic value of tumor budding has not been reported in GBCSCC. The aim of our study was to evaluate the role of pattern of invasion (POI) at the ITF, Tumor budding and other clinicopathological parameters in predicting nodal metastases and prognosis in GBCSCC. 33 patients with primary GBCSCC were prospectively evaluated at a tertiary care referral centre. Tumor budding and type of POI was examined in detail and data documented. Statistical analyses were carried out to assess the correlation of tumor budding, POI, and other clinicopathologic parameters (stage, grade of the tumor, tumor thickness, PNI, LVI) with nodal metastases and predict prognosis. Cox regression was used for both Univariate and multivariate analysis. Significant predictors of nodal metastases on Univariate analysis were male gender (p = 0.021), smoking (p = 0.046), Tumor budding (p = 0.014) and diffuse infiltrative/worst POI (p = 0.004), where as on multivariate analysis only worst POI was significantly associated with positive lymph nodes (p = 0.004). Presence of nodal metastases (p = 0.01) and tumor thickness [5 mm (p = 0.009) were independent negative prognostic factors on multivariate analysis. Significant single risk factor predictive of positive lymph nodes is worst POI in GBCSCC. Nodal metastases and [5 mm tumor thickness are independent risk factors for disease free survival.

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Section: Role Of Tumor Budding In Gbcscccontrasting

confidence: 63%

Section: Histopathological Evaluationmentioning

confidence: 99%

Section: Role Of Tumor Budding In Gbcsccmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Prognostic and Predictive Factors in Gingivo Buccal Complex Squamous Cell Carcinoma: Role of Tumor Budding and Pattern of Invasion

Manjula

Augustine

Selvam³

et al. 2014

Indian J Otolaryngol Head Neck Surg

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“…Tumor budding was also reported as the prognostic factor for lymph node metastasis in other cancers such as esophageal, laryngeal, nasopharyngeal, and skin cancers [31][32][33][34]. In oral cancer, few studies have evaluated tumor budding as a prognostic factor or risk factor for lymph node metastasis, with only three studies reviewing the evaluation of both histopathological depth and tumor budding.…”

Section: Discussionmentioning

confidence: 99%

Predictive Significance of Tumor Depth and Budding for Late Lymph Node Metastases in Patients with Clinical N0 Early Oral Tongue Carcinoma

Hori

Kubota

Yokose

et al. 2017

Head and Neck Pathol

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Correlation of gene methylation in surgical margin imprints with locoregional recurrence in head and neck squamous cell carcinoma

Hayashi

Roh

et al. 2015

Cancer

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Background Securing negative surgical margins is a critical goal for head and neck surgery. Local recurrence occurs even in some cases with histologically negative surgical margins. Minimal residual tumor cells may lead to locoregional recurrence despite clear histologic margins reported at the time of resection of head and neck squamous cell carcinoma (HNSCC). In order to identify subclinical residual disease, we analyzed deep margin imprint samples collected on one layer nitrocellulose sheets. Methods Bisulfite treated DNA from 73 eligible cases was amplified by quantitative methylation-specific polymerase chain reaction (QMSP) targeting 6 genes (DCC, EDNRB, HOXA9, KIF1A, NID2, NR2B). QMSP values were dichotomized as positive or negative. Associations between the QMSP status of deep margin samples and clinical outcomes were evaluated. Results Two gene methylation combinations among DCC, EDNRB and HOXA9 were associated with decreased locoregional recurrence-free survival (LRFS), recurrence-free survival (RFS) and overall survival (OS). The methylated gene combination EDNRB and HOXA9 in margin imprints was the most powerful predictor of poor LRFS (HR=3.31, 95% CI=1.30-8.46; P=0.012), independent of standard histological factors. In addition, methylation of EDNRB/HOXA9 showed a trend toward reduced RFS (HR=2.74, 95% CI=0.90-8.33; P=0.075) and OS (HR=5.78, 95% CI=0.75-44.7; P=0.093) by multivariable analysis. Conclusion A panel of gene methylation targets in deep surgical margin imprints provides a potential predictive marker of post-operative locoregional recurrence. Intra-operative use of molecular margin-imprint analysis might assist surgeons to obtain rigorously negative surgical margins and improve the outcome of head and neck surgery.

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Tumor budding as a prognostic marker in laryngeal carcinoma

Cited by 63 publications

References 21 publications

Prognostic and Predictive Factors in Gingivo Buccal Complex Squamous Cell Carcinoma: Role of Tumor Budding and Pattern of Invasion

Prognostic and Predictive Factors in Gingivo Buccal Complex Squamous Cell Carcinoma: Role of Tumor Budding and Pattern of Invasion

Predictive Significance of Tumor Depth and Budding for Late Lymph Node Metastases in Patients with Clinical N0 Early Oral Tongue Carcinoma

Correlation of gene methylation in surgical margin imprints with locoregional recurrence in head and neck squamous cell carcinoma

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