Tumor Cells Secrete a Vascular Permeability Factor That Promotes Accumulation of Ascites Fluid

Abstract

Tumor ascites fluids from guinea pigs, hamsters, and mice contain activity that rapidly increases microvascular permeability. Similar activity is also secreted by these tumor cells and a variety of other tumor cell lines in vitro. The permeability-increasing activity purified from either the culture medium or ascites fluid of one tumor, the guinea pig line 10 hepatocarcinoma, is a 34,000- to 42,000-dalton protein distinct from other known permeability factors.

Small Molecule Derived From Carboxyethylpyrrole Protein Adducts Promotes Angiogenesis in a Mouse Model of Peripheral Arterial Disease

“…CEP03 significantly increased EC proliferation by 27±19% in normoxic condition and by 27±18% in hypoxic conditions ( P <0.05). These relative increases were comparable to those caused by VEGFA22, 23, 24 (32±19% and 22±10% under normoxic and hypoxic conditions, respectively; P <0.05; Figure 3). In addition, the enhancement in proliferation was not observed when CEP03 was incubated with fibroblast under the same conditions (Figure 4).…”

Involvement of circulating endothelial progenitor cells and vasculogenic factors in the pathogenesis of diabetic retinopathy

“…3 Increased local expression of vascular endothelial growth factor (VEGF) has drawn much attention relating to the pathogenesis of diabetic retinopathy. Evidences suggest that VEGF, a cytokine that acts as an endothelial cell mitogen, 4,5 and induces increased microvascular permeability, 6 is causally involved in the development of diabetic retinopathy. 7,8 Although intraocular levels of VEGF have been studied extensively, systemic vasculogenic factors have not been fully evaluated in previous studies.…”

Concentration of vascular endothelial growth factor (VEGF) in the serum of patients with suspected ovarian cancer

“…While a variety of growth factors exhibit angiogenic activity, there is strong evidence for a pivotal role of VEGF in tumour angiogenesis. Vascular endothelial growth factor (VEGF), which is also known as vascular permeability factor (VPF), stimulates angiogenesis by increasing vascular permeability (Senger et al, 1983) and by acting as an endothelial cell mitogen (Ferrara and Heinzel, 1989). VEGF is a dimeric glycoprotein with four spliced variants consisting of 121, 165, 189 and 206 amino acid residues expressing almost identical biological activities by binding to specific class III receptor tyrosine kinases (flt-l and KDR) (Neufeld et al, 1996;Terman and Dougher-Vermazen, 1996).…”