Tumor de células granulares cutáneo

Torrijos-Aguilar, A.; Miquel, V. Alegre-de; Pitarch-Bort, Gerard; García, Pedro Mercader; Fortea-Baixauli, J.M.

doi:10.1016/s0001-7310(09)70230-3

Cited by 56 publications

(19 citation statements)

References 16 publications

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“…A biopsy was carried out (Figure 2) and a histologic examination (Figure 3) of the biopsy suggested GCT, and deferred immunohistochemi-cal examination showed the typical receptors of this tumor (Table 1). In our case, GCT showed positive immunoreaction to PAS, PAS diastase and S-100, and calretinin and negative immunoreactivity against cytokeratin, estrogen, progesterone receptors, and also to HER2/Neu receptors; also, negative receptors for cytokeratin confirmed the diagnosis of GCT 12,13…”

Section: Case Reportsupporting

confidence: 61%

Granular cell tumor in breast: a case report

Lara¹,

Herrera²,

Cardoso³

et al. 2017

BCTT

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Granular cell tumor (GCT) is a rare neoplasm of the soft tissues, and <1% of all GCTs are malignant. It usually appears in the tongue and sometimes may affect the female breast. Initially, GCT was considered to be a myogenic lesion affecting female breast (myoblastoma). Actually, it is assumed as a tumor originating from perineural or putative Schwann cells of peripheral nerves or their precursors that grows in the lobular breast tissue, due to the immunohistochemical features. Here, we review the importance of differentiating between this tumor and malignant breast carcinoma. Mammographically, by ultrasound scan and clinically, this case appears to be a malignant tumor of the breast, but with a correct and precise diagnosis including histopathologic examination and immunohistochemical studies, it was correctly identified as a GCT.Case detailsWe present a case of a 52-year-old premenopausal woman. This report is of interest because of patient’s familial oncologic history and personal history of gynecologic cancer. This rare tumor of the breast and the special way to approach the tumor by local anesthesia makes it interesting to communicate.ConclusionThis is a case of interest because GCT located in the breast is very unusual and knowledge of GCT is required for the differential diagnosis with breast cancer.

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Section: Case Reportsupporting

confidence: 61%

Granular cell tumor in breast: a case report

Lara¹,

Herrera²,

Cardoso³

et al. 2017

BCTT

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“…8 Those hyperplasias are oblong stripes of squamous cells that extend down into the tumor tissue, forming columns. Occasionally, the tumor can invade the epidermis, in which case differentiation from melanoma can be difficult.…”

Section: Discussionmentioning

confidence: 99%

“…Both tumors are strongly positive for S-100, but HMB-45 and melan-A are negative in the case of granular cell tumor. 7-8 The differential diagnosis also includes leiomyoma and angiosarcoma, which can also have super populations of cells with a granular cytoplasm. Cases of malignant (1%) granular cell tumors have been reported.…”

Section: Discussionmentioning

confidence: 99%

Case for diagnosis

Dell'Horto

Pinto

Diniz

2013

An. Bras. Dermatol.

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Granular cell tumor (Abrikossoff's tumor) is a rare benign disease that preferentially affects the cervicofacial segment. It is usually a solitary nodule that may ulcerate and present pearly infiltration on the borders, while keeping a clean background and a hyperchromic halo. This paper describes the case of an ulcerated granular cell tumor on an unusual location, which reinforces the necessity of including this tumor in the differential diagnosis of nodular-ulcerative skin lesions.

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“…Five to 25% of patients have multiple lesions [15], depending on the series and this large range is probably related to the difference in the follow-up period. Cases of GCTs affecting several organs simultaneously have been reported.…”

Section: Discussionmentioning

confidence: 99%

Benign Granular Cell Tumor of the Vulva: First Report of Multiple Cases in a Family

Kardhashi

Deliso

Renna

et al. 2012

Gynecol Obstet Invest

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Granular cell tumors (GCTs) are uncommon soft tissue tumors of neural derivation, as supported by immunohistochemical and ultrastructural evidence. Vulvar involvement has been reported in 7–16%. This paper presents the cases of a 60-year-old woman and her 32-year-old niece with a strong family history of cancer, both presenting with an enlarging mass on their left labia majora. The lesions were treated by simple surgical excision. Histopathological examination revealed a benign vulvar GCT in both lesions. This is the first reported case of GCT of the vulva in the same family. The possible familial component of GCT needs further investigation. A systematic review of the literature on vulvar GCTs is carried out, the most complete one to date. This review unexpectedly reveals that there have been more than 130 cases of GCT of the vulva reported to date, only 7 of which were malignant. Since 5–25% of patients have multiple lesions, before planning treatment, clinicians should exclude multicentric lesions. After surgical treatment, if there is any evidence of tumor in the surgical margin, wider local excision should be performed. Regular follow-up is important for diagnosing a possible recurrence or a new lesion.

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Tumor de células granulares cutáneo

Cited by 56 publications

References 16 publications

Granular cell tumor in breast: a case report

Granular cell tumor in breast: a case report

Case for diagnosis

Benign Granular Cell Tumor of the Vulva: First Report of Multiple Cases in a Family

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