Tumor Depth as a Predictor of Lymph Node Metastasis of Supraglottic and Hypopharyngeal Cancers

Tomifuji, Masayuki; Imanishi, Yorihisa; Araki, Koji; Yamashita, Taku; Yamamoto, Sohei; Kameyama, Kaori; Shiotani, Akiko

doi:10.1245/s10434-010-1219-5

Cited by 57 publications

(44 citation statements)

References 17 publications

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“…Some studies have demonstrated a correlation between invasion distance and lymph node metastasis and have suggested that lymph node metastasis occurs once the tumor has progressed to subepithelial cancer. It is therefore of great significance to obtain a preoperative diagnosis of subepithelial cancer before endoscopic treatment.…”

Section: Discussionmentioning

confidence: 99%

Utility of magnifying endoscopy with narrow band imaging in determining the invasion depth of superficial pharyngeal cancer

et al. 2014

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Section: Discussionmentioning

confidence: 99%

Utility of magnifying endoscopy with narrow band imaging in determining the invasion depth of superficial pharyngeal cancer

et al. 2014

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“…On the other hand, tumor size and tumor depth did not show a correlation 27. In several studies, tumor depth has been shown to be an independent predictor of increased incidence of regional metastasis and worse survival 28–31. The main drawback of these studies is the small number of patients treated.…”

Section: Discussionmentioning

confidence: 99%

Incidence of occult cervical metastasis in head and neck carcinomas: Development over time

Psychogios

Mantsopoulos

Bohr

et al. 2012

Journal of Surgical Oncology

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Background With the development of imaging techniques in diagnostics of head and neck carcinomas, especially computed tomography and ultrasonogaphy, one might expect that the incidence of occult metastases would be reduced. The aim of this study was to determine the rate of occult metastases in a large population cohort and explore its changes with improvement of imaging techniques over the last 30 years. Methods All patients between 1980 and 2010 with head and neck carcinoma and cN0 neck status were retrospectively evaluated. Six hundred thirty‐six patients with cN0 neck who received an elective neck dissection as part of a definitive surgical treatment were included. Results The overall rate of occult metastases was 24.8% (158/636). The rate was 26.5% (80/302) between 1980 and 1995 and 23.4% (78/334) between 1995 and 2010. Only pT1–2 glottic carcinomas had an occult metastases rate of less than 10%. All other pT1–2 carcinomas had an incidence of occult metastases between 19.1% and 42.5%. pT3–4 tumors showed an occult metastases rate of 24.5–53.3%. Conclusion The occult metastases rate showed only a marginal improvement over the last 30 years and is still above the 20% margin. All but pT1–2 glottic carcinomas should be considered for elective treatment of the neck. J. Surg. Oncol. 2013;107:384–387. © 2012 Wiley Periodicals, Inc.

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“…The results of previous investigations have been inconsistent; there is evidence that tumor thickness correlates with lymph node metastasis . However, results from other studies indicate that the depth of invasion is the only prognostic factor in superficial pharyngeal cancers . Regarding pharyngeal cancers, the current guidelines do not recommend the prediction of prognosis based on either tumor thickness or depth of invasion .…”

Section: Discussionmentioning

confidence: 92%

Prediction of the depth of invasion in superficial pharyngeal cancer: Microvessel morphological evaluation with narrowband imaging

et al. 2019

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Background Magnifying endoscopy with narrowband imaging (ME‐NBI) is useful in predicting the invasion depth by examining the microvascular status of tumor surfaces. This retrospective study aimed to determine its efficacy in pharyngeal cancer. Methods Between April 2016 and March 2018, 59 lesions from 46 patients who underwent transoral resection were retrospectively analyzed. Using ME‐NBI, microvascular status was classified into B1, B2, or B3, based on the classification of the Japan Esophageal Society. Results A significant correlation was observed between microvascular status and invasion depth (P = .011). Mean thickness of lesions with B1, B2, and B3 vessels were 563, 1364, and 2825 μm, respectively (P = .006). In previously treated lesions, a significant correlation was observed between microvascular status and invasion depth (P = .012). Conclusions ME‐NBI is useful in predicting the invasion depth and thickness of pharyngeal tumors, even in patients with previously treated lesions.

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Tumor Depth as a Predictor of Lymph Node Metastasis of Supraglottic and Hypopharyngeal Cancers

Cited by 57 publications

References 17 publications

Utility of magnifying endoscopy with narrow band imaging in determining the invasion depth of superficial pharyngeal cancer

Utility of magnifying endoscopy with narrow band imaging in determining the invasion depth of superficial pharyngeal cancer

Incidence of occult cervical metastasis in head and neck carcinomas: Development over time

Prediction of the depth of invasion in superficial pharyngeal cancer: Microvessel morphological evaluation with narrowband imaging

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