Tumor Embolus and Distant Metastasis in Renal Adenocarcinoma

Saitô, Hiroshi; Kato, Mikio; Yamauchi, A; Ishiwata, Daisuke; Yokokawa, Masayuki; Aoki, Nozomi; Takahama, Motohide

doi:10.5980/jpnjurol1928.70.10_1072

Cited by 4 publications

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“…3 ). Aggregated cancer cells have been shown to increase metastasis because they can evade attacks from the immune system 40 , 41 . Surface-bound vWF multimers can also link BGC823 cells to platelets through the RGD site in the C-domain and the GP Ibα binding site in the A1 domain (Figs.…”

Section: Discussionmentioning

confidence: 99%

Cancer cell-derived von Willebrand factor enhanced metastasis of gastric adenocarcinoma

Yang

Wang

et al. 2018

Oncogenesis

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Cancer prognosis is poor for patients with blood-borne metastasis. Platelets are known to assist cancer cells in transmigrating through the endothelium, but ligands for the platelet-mediated cancer metastasis remain poorly defined. von Willebrand factor (vWF) is a major platelet ligand that has been widely used as a biomarker in cancer and associated inflammation. However, its functional role in cancer growth and metastasis is largely unknown. Here we report that gastric cancer cells from patients and cells from two well-established gastric cancer lines express vWF and secrete it into the circulation, upon which it rapidly becomes cell-bound to mediate cancer-cell aggregation and interaction with platelets and endothelial cells. The vWF-mediated homotypic and heterotypic cell–cell interactions promote the pulmonary graft of vWF-overexpressing gastric cancer BGC823 cells in a mouse model. The metastasis-promoting activity of vWF was blocked by antibodies against vWF and its platelet receptor GP Ibα. It was also reduced by an inhibitory siRNA that suppresses vWF expression. These findings demonstrate a causal role of cancer-cell-derived vWF in mediating gastric cancer metastasis and identify vWF as a new therapeutic target.

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Section: Discussionmentioning

confidence: 99%

Cancer cell-derived von Willebrand factor enhanced metastasis of gastric adenocarcinoma

Yang

Wang

et al. 2018

Oncogenesis

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Distant metastasis of renal adenocarcinoma

Shinmoto

1981

Cancer

319

117

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Renal adenocarcinoma in 1451 autopsy cases was classified according to the number of organs involved in distant metastasis, and the mode of metastasis. In cases with single-organ metastasis, lung and lymph node involvement was low (32% and 12%, respectively), but increased as the number of metastatically involved organs increased. Frequency of metastases to the pancreas, heart, and intestine rapidly increased as the number of involved organs increased, while the incidence of metastasis to the brain remained unchanged, regardless of the number of organs involved. A significant correlation was observed between metastases to the lung and organs involved. A significant correlation was observed between metastases to the lung and those to the pulmonary and tracheal lymph nodes, but not between those to the lung and those to the retroperitoneal lymph nodes. While the frequency of metastases to the contralateral kidney and brain was significantly higher in cases with recurrence after nephrectomy than in those who did not undergo nephrectomies, the frequencies of metastases to other organs was similar in these two groups. The number of metastatically involved organs is useful in analyzing the mode of metastasis.

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Distant Metastasis of Renal Adenocarcinoma in Patients with a Tumor Thrombus in the Renal Vein and/or Vena Cava

Shinmoto

1982

Journal of Urology

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Autopsy records of renal adenocarcinoma cases were analyzed to investigate the mode of metastatic spread in instances of a tumor thrombus in the renal vein and/or vena cava. In this series of 1,828 cases 137 (7.5 per cent) had a tumor thrombus. Analysis revealed no significant differences in the incidence of the tumor thrombus between sexes or sides of primary renal involvement, or whether nephrectomy had been performed. The cases with a tumor thrombus showed higher frequencies of metastases in the liver, hepatic hilar lymph nodes and ureter, while metastases in the bones, contralateral kidney and brain were less frequent. The results suggest that bypass routes or lymphogenous spread of the tumor might be facilitated in some cases with a tumor thrombus.

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Tumor Embolus and Distant Metastasis in Renal Adenocarcinoma

Cited by 4 publications

References 0 publications

Cancer cell-derived von Willebrand factor enhanced metastasis of gastric adenocarcinoma

Cancer cell-derived von Willebrand factor enhanced metastasis of gastric adenocarcinoma

Distant metastasis of renal adenocarcinoma

Distant Metastasis of Renal Adenocarcinoma in Patients with a Tumor Thrombus in the Renal Vein and/or Vena Cava

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