Tumor Eradication by Radiofrequency Therapy-Reply

Radio frequency hyperthermia of advanced human sarcomas

“…These higher temperatures may have greater therapeutic benefit because significant tumor necrosis can be achieved in much less time than required at lower temperatures [6,7]. Indirect evidence suggests that tumors can be selectively heated because tumor blood flow is comparatively poor and sluggish [7, 11,13]. Tumor neovascularity seems to be incapable of augmenting blood flow in response to heat, in contrast to normal tissues [10,12].…”

“…Hyperthermia has been shown to be tumoricidal in vitro [1][2][3][4] in animals with induced [5-91 and spontaneous neoplasmas [lo] and in man with various types of solid cancer [2,[11][12][13]. At temperatures from 42 to 44°C (108-111°F) tumor cells seem to be slightly more thermosensitive than normal cells, [l-5,8,9] and appear to be killed at approximately 1°C lower temperature.…”

“…At temperatures from 42 to 44°C (108-111°F) tumor cells seem to be slightly more thermosensitive than normal cells, [l-5,8,9] and appear to be killed at approximately 1°C lower temperature. Temperatures 5 45°C (1 13°F) have been achieved selectively in some solid cancers, [7, [9][10][11][12]15-181 probably because the tumor tissue is unable to dissipate the heat effectively, as does normal tissue [7, 9-131. Higher temperatures may cause more necrosis and would seem to be more efficacious in terms of practical treatment time [ 1,6,7]. Surface tissue injury [5] has precluded investigation of deep visceral hyperthermia, until recently.…”