2015
DOI: 10.1016/j.semcancer.2015.09.012
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Tumor-extracellular matrix interactions: Identification of tools associated with breast cancer progression

Abstract: Several evidences support the concept that cancer development and progression are not entirely cancer cell-autonomous processes, but may be influenced, and possibly driven, by cross-talk between cancer cells and the surrounding microenvironment in which, besides immune cells, stromal cells and extracellular matrix (ECM) play a major role in regulating distinct biologic processes. Stroma and ECM-related signatures proved to influence breast cancer progression, and to contribute to the identification of tumor ph… Show more

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Cited by 133 publications
(116 citation statements)
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“…The stromal microenvironment of DCIS largely consists of an insoluble ECM, comprised a complex mixture of glycoproteins, proteins, proteoglycans and polysaccharides 41. Also within the ECM surrounding the duct are populations of adipocytes, fibroblasts, mesenchymal stem cells, endothelial and immune cells that produce a multitude of growth factors and cytokines.…”
Section: Tumour Cell Extrinsic Factors Involved In Dcis Progressionmentioning
confidence: 99%
“…The stromal microenvironment of DCIS largely consists of an insoluble ECM, comprised a complex mixture of glycoproteins, proteins, proteoglycans and polysaccharides 41. Also within the ECM surrounding the duct are populations of adipocytes, fibroblasts, mesenchymal stem cells, endothelial and immune cells that produce a multitude of growth factors and cytokines.…”
Section: Tumour Cell Extrinsic Factors Involved In Dcis Progressionmentioning
confidence: 99%
“…Tumours are complex entities that include genetically and metabolically aberrant cancer cells, genetically stable stromal cells, and infiltrating immune cells. They are functionally dependent on the acidic, hypoxic, and poorly perfused serum-deprived microenvironment that surrounds them for cancer progression to occur (12,13).…”
Section: Introductionmentioning
confidence: 99%
“…Although many ECM components have been identiied as relevant factors in breast cancer progression, evaluation and targeting of a single molecule appears to have limited usefulness in predicting therapeutic response. This might atribute to the large number of ECM components, which, even if likely redundant, collectively contribute to distinctive physical, biochemical, and biomechanical properties of the tumor microenvironment [8]. In gene expression, proiles of breast cancer-associated ibroblasts identify distinct stromal paterns with prognostic implication, and the expression proiles of some extracellular matrix genes provide prognostic information of patients at risk of clinical progression and/or predictive signiicance for treatment eicacy.…”
Section: Introductionmentioning
confidence: 99%