Tumor growth, angiogenesis and inflammation in mice lacking receptors for platelet activating factor (PAF)

Antitumoral and antiangiogenic activity of Synadenium umbellatum Pax

“…tumor cells, inflammatory cells, and mesothelial cells), mainly VEGF (Teixeira et al, 2006;Ferreira et al, 2007). VEGF has been extensively demonstrated to be present at high concentrations and to play a crucial role in increasing the permeability of the surrounding vasculature in a variety of human and experimental animals bearing ascites tumors (Shibuya et al, 1999;Stoelcker et al, 2000).…”

Controlled release of triamcinolone acetonide from polyurethane implantable devices: application for inhibition of inflammatory-angiogenesis

“…The extent of neutrophil accumulation in the sponge discs was measured by assaying myeloperoxidase (MPO) activity [46]. After processing the supernatant of the sponges (n = 6 for each group) for the hemoglobin determination, a part of the corresponding sponge was weighed, homogenized in 2 mL of buffer pH 4.7 (0.1 M NaCl, 0.02 M Na 3 PO 4 , 0.015 M Na 2 -EDTA) and centrifuged at 4°C at 12,0009g for 10 min.…”

“…The infiltration of mononuclear cells into the sponge discs was quantified by measuring the levels of the lysosomal enzyme N-acetyl-b-D-glucosaminidase (NAG) which is present in high levels in activated macrophages [46]. A portion of the sponges that remained after the hemoglobin measurement was kept for this assay (n = 6 for each group).…”

Development of thalidomide-loaded biodegradable devices and evaluation of the effect on inhibition of inflammation and angiogenesis after subcutaneous application

“…In order to evaluate the extent of neutrophil accumulation in the sponge discs, the activity of myeloperoxidase (MPO) was measured according to the technique previously described by Ferreira and coworkers [14].…”