Tumor immunity

Humphrey, Loren J.

doi:10.1016/0022-4804(70)90075-2

Cited by 14 publications

(5 citation statements)

References 93 publications

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“…Autologous and allogenic lymphocytes have been used in experimental immunotherapy of neoplasms in man (Humphrey, 1970) with lo9 to 10l2 sensitized leukocytes administered in passive transfer. Leukocytes have been exchanged between patients who were cross-immunized (Krementz and Samuels, 1967;Humphrey et al, 1969), and large numbers of sensitized cells have been obtained from in vitro cultures of lymphocytes (Nadler and Moore, 1969).…”

Section: Introductionmentioning

confidence: 99%

“…Previous reports (Mitchinson, 1955;Weaver et al, 1955;Algire et al, 1957;Klein and Klein, 1962;Old and Boyse, 1964;Alexander, 1965;Southam, 1968; Stewart, 1969) suggested that the immunological defense against cancer was predominantly a cell-mediated response. Autologous and allogenic lymphocytes have been used in experimental immunotherapy of neoplasms in man (Humphrey, 1970) with lo9 to 10l2 sensitized leukocytes administered in passive transfer. Leukocytes have been exchanged between patients who were cross-immunized (Krementz and Samuels, 1967;Humphrey et al, 1969), and large numbers of sensitized cells have been obtained from in vitro cultures of lymphocytes (Nadler and Moore, 1969).…”

Section: Introductionmentioning

confidence: 99%

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Effects of pig leukocytes on mouse lymphatic leukemia

Hill

Kelly

et al. 1971

Journal of Surgical Oncology

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Sensitized leukocytes from live pigs and isolated, perfused pig spleens produced a significant immunotherapeutic effect in AKR mice injected with syngeneic BW 5147 lymphatic leukemia. Therapeutically useful leukocytes were obtained from tumor-sensitized ex vivo perfused pig spleens and from both spleens and peripheral blood of tumor-sensitized live pigs. Therapeutic benefit was achieved only when leukocytes were incubated with tumor cells prior to injection into mice. Normal pig leukocytes were relatively less effective against tumor cells. Normal mice tolerated two injections of lo6 to lo8 pig leukocytes without ill effect.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effects of pig leukocytes on mouse lymphatic leukemia

Hill

Kelly

et al. 1971

Journal of Surgical Oncology

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“…If drastic reduction in immunosuppression fails to control the neoplasm, then some form of immunotherapy can be attempted (9,11,14).…”

Section: Treatment Of Tumorsmentioning

confidence: 99%

Malignant tumors arising de novo in immuno-suppressed organ transplant recipients

Penn¹,

Starzl²

1973

Plastic and Reconstructive Surgery

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SUMMARYDe novo malignant tumors have been observed throughout the world in 75 chronic survivors of organ transplantation, including 16 of our own patients. The incidence of tumors was approximately 80 times greater than in the average population in a comparable age range. Chronic uremia may have predisposed to the development of some of the tumors, but this has not yet been proved. It seems clear that the predominant etiology was chronic immunosuppression post-transplantation. Forty-four of the patients had epithelial tumors and in 31 the lesions were of mesenchymal origin. On the average the malignancies appeared 29 months after transplantation. Lymphomas showed an unusual predilection for involvement of the central nervous system. Carcinomas of the skin, lip, and uterine cervix were successfully treated by conventional techniques. On the other hand, carcinomas of the thoracic or abdominal organs and mesenchymal tumors led or contributed to early death in most cases. For this reason drastic reduction or even discontinuance of immunosuppression should be considered in the management of these , latter tumors.

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“…(Arch Otolaryngol 101: [667][668][669][670]1975) used in the management of organ transplant recipients and in a variety of disease states depress cellular and humoral immune responses and lead to an increased incidence of cancer both in experimental animals8 and in man.9141 consider three groups of pa¬ tients who received immunosuppres¬ sive therapy: (1) organ homograft re¬ cipients; (2) lymph node metastasis behind the angle of the mandible, which was treated by reexcision of the left ear, superficial parotid lobectomy, and radical neck dissection (Fig 1). At present, the patient has recurrent neo¬ plasm in the neck and métastases in the lumbar part of the spine and in the liver.…”

mentioning

confidence: 99%

Immunosuppression and Cancer: Importance in Head and Neck Surgery

Penn¹

1975

Archives of Otolaryngology - Head and Neck Surgery

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Tumor immunity

Cited by 14 publications

References 93 publications

Effects of pig leukocytes on mouse lymphatic leukemia

Effects of pig leukocytes on mouse lymphatic leukemia

Malignant tumors arising de novo in immuno-suppressed organ transplant recipients

Immunosuppression and Cancer: Importance in Head and Neck Surgery

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