Tumor-infiltrating immune cell activated memory CD4+ T cells predicts prognosis in gastric cancer

Abstract

Background: Tumor-infiltrating immune cells (TIICs) play an important role in gastric cancer pathogenesis and are promising prognostic biomarkers. However, the prognostic value of activated memory CD4+ T cells remains unclear. Methods: The aim of this study is to explore the value of activated memory CD4+ T cells and the risk model predicting the prognosis in GC. We analyzed the composition of 22 TIICs in GC by the CIBERSORT algorithm using RNA-seq data, we also evaluated the prognostic value of TIICs by constructing the risk model. Furthermore, we performed Kaplan-Meier survival and Cox regression analysis to evaluate the prognosis of GC. Results: The results showed that the high expression of activated memory CD4+ T cells indicated a better overall survival. Risk score was identified as an independent prognostic factor which means activated memory CD4+ T cells can predict prognosis well in gastric cancer. Conclusions: Our study verified the expression of IL23A was associated with the overall survival of GC patients, and its low expression indicated a poor prognosis, which confirms the reliability of activated memory CD4+ T cells as a prognostic factor in gastric cancer.