Tumor inhibitors. 119. Baccharin, a novel potent antileukemic trichothecene triepoxide from Baccharis megapotamica

Composition and antimicrobial activity of the essential oil from aerial parts of Baccharis trinervis (Lam.) Pers

“…2,3 Regarding to biological activities, antifungal, antiviral, antileukemic, analgesic, antioxidant and antiinflammatory properties have been reported for plants of this genus. 2,[4][5][6][7] About 100 species have been investigated chemically and several classes of secondary metabolites such as sesquiterpenes, diterpenes, chromenes, flavones and trichothecenes have been isolated. 1,8-11 B. trinervis is a perennial shrub, used in folk medicine as antiseptic, digestive and to treat snakebites and it is widely distributed from Mexico to Argentina.…”

Macrocyclic trichothecenes from brazilian Baccharis species: From microanalysis to large‐scale isolation

“…Crude ethanolic extracts of B. megapotamica were highly active both in uitro (cytotoxicity in KB cells) as well as in uiuo (against murine P388 leukaemia). Four sets of diastereomers, baccharinoids Bl-B8, belonging to the well-known trichothecene class of fungal mycotoxins, were isolated from the extract and shown to be the active principles (Kupchan et al, 1976(Kupchan et al, , 1977Jarvis et al, 1987a). One of the striking features of this finding was that previous in uioo testing of macrocyclic trichothecenes (e.g.…”

Progress in Molecular and Subcellular Biology

“…In the course of a continuing search for tumor inhibitors obtained from extracts of higher plants, Kupchan et al (1976) discovered that trichothecenes were present in the extracts of a Brazilian shrub Baccharis megapotamica. This indeed was a surprising discovery since trichothecenes were only known to be secondary metabolites of a variety of Fungi irrrperfecti.…”

“…However translocation from the roots to the leaves appears to occur with T-2 toxin and trichodermol (Maras as et al 1971;Cutler and LeFiles 1978). The most dramatic uptake and translocation of trichothecenes was discovered in the Brazilian shrub Baccaris megapotamica (Kupchan et al 1976;Jarvis et al 1981c). This shrub is completely resistant to the effects of roridin A and verrucarin A and yet it will take up these compounds through the root system, transform them to their 8B-hydroxy-derivative and concentrate them in the leaf.…”