Tumor Location Correlates with Clinicopathological Features and Prognosis of the Solid Pseudopapillary Neoplasm

Meng, Zhaoqing; Cao, Mingsi; Wang, Feiyang; Zhang, Yushun; Wu, Heshui

doi:10.1155/2018/9023947

Cited by 6 publications

(3 citation statements)

References 20 publications

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“…The SPN of the pancreas represents an unusual and rare tumor, with multiple literature reports around the world [ 5 , 12 , 13 , 14 , 15 , 16 , 17 ]. As observed by Papavramidis et al, approximately 90% of them were females, and 72% of the patients were included in the age group of 19–50 years old.…”

Section: Discussionmentioning

confidence: 99%

Clinical Course, Genetic, and Immunohistochemical Characterization of Solid Pseudopapillary Tumor of the Pancreas (Frantz Tumors) in a Brazilian Cohort

Tostes

Carvalho

Araújo

et al. 2022

Genes

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Frantz tumors or solid pseudopapillary pancreatic neoplasm (SPN) are rare exocrine neoplasms that carry a favorable prognosis; they represent up to 3% of all tumors located in the region of the pancreas and have specific age and gender predispositions. In recent years, the rising curve of diagnosis is entitled to the evolution and access of diagnostic imaging. In this paper, we have retrospectively reviewed and described the clinical course of 40 patients with SPN from three institutions in Brazil, who had their diagnosis between 2005 and 2020, and analyzed the clinicopathological, genetic, and surgical aspects of these individuals. In accordance with the literature, most patients were women, 60% with unspecified symptoms at diagnosis, with tumors mainly located in the body and tail of the pancreas, of whom 70% underwent a distal pancreatectomy with sparing splenectomy as a standard procedure, and none of the cases have experienced recurrence to date. Surgery still remains the mainstay of treatment given the low metastatic potential, but more conservative approaches as observed in this cohort are evolving to become the standard of care. Herein, we present an in-depth analysis of cases focusing on the latest literature and report some of the smallest tumor cases in the literature. To our knowledge, this is the first report evaluating germline genetic testing and presenting a case of detected Li-Fraumeni syndrome.

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Section: Discussionmentioning

confidence: 99%

Clinical Course, Genetic, and Immunohistochemical Characterization of Solid Pseudopapillary Tumor of the Pancreas (Frantz Tumors) in a Brazilian Cohort

Tostes

Carvalho

Araújo

et al. 2022

Genes

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“…Whilst the Ki67 index ≥4% has been reported to show poor recurrence-free, its role is still debateable [ 8 , 11 ].…”

Section: Discussionmentioning

confidence: 99%

Synchronous solid pseudopapillary neoplasm of the pancreas with intrahepatic cholangiocarcinoma in a young male patient: An unusual deadly occurrence

Khaba

Kalenga

Phetla

et al. 2021

International Journal of Surgery Case Reports

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Highlights Solid pseudopapillary neoplasm of the pancreas is rare in males. Intrahepatic cholangiocarcinoma is not uncommon in the African population, however is rare in younger population. According to the literature search, this is the first case of synchronous solid pseudopapillary neoplasm of the pancreas and intrahepatic cholangiocarcinoma. Multidisciplinary team is important in management of cases with clinical conundrum.

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“…Women and men have the same prognosis [3] and the multicentric forms have similar clinical and pathologic features to the solitary ones [14]. However, when the tumors are located in the head, the disease-free and the overall survivals are significantly shorter than those of other locations [32]. When metastases develop, they usually occur late, 8 to 15.8 years after complete resection of the primary [21,31,33,34].…”

Section: Biological Behaviormentioning

confidence: 99%

Solid-pseudopapillary Neoplasms of the Pancreas is still an Enigma: a Clinicopathological Review

Zalatnai

Kis-Orha

2019

Pathol. Oncol. Res.

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The solid-pseudopapillary neoplasm of the pancreas is a rare but enigmatic entity occurring mainly in young women. Since the first description by V. Frantz in 1959 the terminology of this tumor has continuously changed but it has remained simply descriptive, because the exact histogenesis is still obscure. Although in majority of cases the survival is excellent, nevertheless, the expected prognosis is not exactly predictable. In this review the authors aim to summarize its clinico-pathological features, the expected biological behavior, the molecular alterations, the immune phenotype and discuss the putative histogenesis. From diagnostic point of view, the salient histological characteristic findings are analyzed that would help to differentiate it from other, look-alike pancreatic tumors, and suggestions are made about the desirable content of the histological report.

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Tumor Location Correlates with Clinicopathological Features and Prognosis of the Solid Pseudopapillary Neoplasm

Cited by 6 publications

References 20 publications

Clinical Course, Genetic, and Immunohistochemical Characterization of Solid Pseudopapillary Tumor of the Pancreas (Frantz Tumors) in a Brazilian Cohort

Clinical Course, Genetic, and Immunohistochemical Characterization of Solid Pseudopapillary Tumor of the Pancreas (Frantz Tumors) in a Brazilian Cohort

Synchronous solid pseudopapillary neoplasm of the pancreas with intrahepatic cholangiocarcinoma in a young male patient: An unusual deadly occurrence

Solid-pseudopapillary Neoplasms of the Pancreas is still an Enigma: a Clinicopathological Review

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