Tumor manipulation during pancreatic resection for pancreatic cancer induces dissemination of tumor cells into the peritoneal cavity: a systematic review

Steen, M. Willemijn; Duijvenbode, Dennis C. van; Dijk, Frederike; Busch, O.; Besselink, Marc G.; Gerhards, Michael F.; Festen, Sebastiaan

doi:10.1016/j.hpb.2017.08.018

Cited by 5 publications

(2 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Criticism of the LACC study is based on the lack of a standardized surgical technique including possible use of uterine manipulators and intracorporal colpotomy without vaginal cuff closure, which might represent the strongest factor for increased recurrence rates due to intraoperative tumor dissemination . We already know from different cancer entities such as colorectal or pancreatic cancer that intraoperative tumor dissemination by surgical procedures is associated with increased recurrence rates . Several authors actually promote surgical techniques for cervical cancer treatment which aim to prevent tumor spillage during surgery .…”

Section: Introductionmentioning

confidence: 99%

“…1,8,9 We already know from different cancer entities such as colorectal or pancreatic cancer that intraoperative tumor dissemination by surgical procedures is associated with increased recurrence rates. [11][12][13] Several authors actually promote surgical techniques for cervical cancer treatment which aim to prevent tumor spillage during surgery. 9,14,15 To our knowledge, studies analyzing the probability or mechanisms of intraoperative peritoneal tumor cell dissemination for cervical cancer are lacking.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Peritoneal contamination with ICG‐stained cervical secretion as surrogate for potential cervical cancer tumor cell dissemination: A proof‐of‐principle study for laparoscopic hysterectomy

Klapdor

Hertel

Hillemanns

et al. 2019

Acta Obstet Gynecol Scand

View full text Add to dashboard Cite

Introduction Intracorporal colpotomy during radical hysterectomy for cervical cancer is discussed to be a risk factor for peritoneal dissemination of tumor cells. It might lead to increased recurrence rates after laparoscopic radical hysterectomy compared with abdominal hysterectomy, as shown by the recent LACC study. Data on the frequency or mechanisms of peritoneal contamination are missing. We aimed to analyze peritoneal contamination of cervical secretion during intracorporal colpotomy with a novel indocyaningreen (ICG)‐based technique. Material and methods In this prospective proof‐of‐principle study, patients undergoing routine laparoscopic or robot‐assisted hysterectomy were selected. ICG was specifically applied to the cervical surface and routine surgery was performed. During colpotomy, pictures under white and fluorescence light were taken to evaluate frequency of contamination. Results By using cervically applied ICG we were able to visualize directly peritoneal contamination with cervical secretion during intracorporal colpotomy. We detected peritoneal contamination in 9/12 (75%) patients undergoing routine laparoscopic hysterectomy. Contamination of laparoscopic instruments occurred in 60% of the patients. When contamination occurred, it was routinely detectable during all steps of colpotomy. There were no adverse effects during surgery. Conclusions Peritoneal contamination with cervical secretion frequently occurs during intracorporal colpotomy. This novel technique represents a promising tool for feasible and direct visualization of peritoneal contamination during colpotomy. The technique may be easily implemented in further studies on laparoscopic and abdominal hysterectomy and serve as a quality assessment tool for surgeons and surgical techniques.

show abstract

Section: Introductionmentioning

confidence: 99%