Tumor necrosis factor-alpha and soluble TNF-alpha receptor responses in young vs. middle-aged males following eccentric exercise

Arroyo, Eliott; Wells, Adam J.; Gordon, Joseph A.; Varanoske, Alyssa N.; Gepner, Yftach; Coker, Nicholas A.; Church, David D.; Fukuda, David H.; Stout, Jeffrey R.; Hoffman, Jay R.

doi:10.1016/j.exger.2017.10.012

Cited by 15 publications

(7 citation statements)

References 34 publications

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“…The exercise bout also induced muscle damage, evidenced by the increased subjective rating of muscle soreness, thigh circumference, and biomarkers (myoglobin and creatine kinase), which are all commonly found to increase after muscle damaging exercise [1,2]. The inflammatory biomarker tumor necrosis factor-α also increased following exercise, which is similar to some [18], but not all [19,20] previous studies that investigated resistance-based exercise.…”

Section: Leg Press Exercisementioning

confidence: 50%

The Effect of Orally Dosed Levagen+™ (palmitoylethanolamide) on Exercise Recovery in Healthy Males—A Double-Blind, Randomized, Placebo-Controlled Study

Mallard

Briskey

Richards³

et al. 2020

Nutrients

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The aim of this study was to evaluate the effect of palmitoylethanolamide (PEA), a cannabimimetic compound and lipid messenger, on recovery from muscle damaging exercise. Twenty-eight healthy young male participants attended the laboratory four times on subsequent days. In the first visit, baseline characteristics were recorded before participants were randomized to consume either liquid PEA (167.5 mg Levagen+ with 832.5 mg maltodextrin) or a matched placebo (1 g maltodextrin) drink. Leg press exercise consisted of four sets at 80% of one repetition maximum followed by a performance set. Muscle soreness, thigh circumference, blood lactate concentration, biomarkers of muscle damage and inflammation, and transcription factor pathways were measured pre- and immediately post-exercise and again at 1, 2, 3, 24, 48, and 72 h post-exercise. The leg press exercise increased (p < 0.05) blood lactate concentration and induced muscle damage as evidenced by increased muscle soreness, thigh circumference, biomarkers of muscle damage, and concentrations of tumor necrosis factor-α. PEA reduced (p < 0.05) myoglobin and blood lactate concentrations and increased protein kinase B phosphorylation following exercise. Taken together, these results indicate PEA supplementation may aid in muscle recovery from repeat bouts of exercise performed within a short duration by reducing myoglobin and lactate concentration.

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Section: Leg Press Exercisementioning

confidence: 50%

The Effect of Orally Dosed Levagen+™ (palmitoylethanolamide) on Exercise Recovery in Healthy Males—A Double-Blind, Randomized, Placebo-Controlled Study

Mallard

Briskey

Richards³

et al. 2020

Nutrients

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show abstract

“…Body mass and height were measured using a Health-O-Meter Professional scale (Patient Weighing Scale, Model 500 KL, Pelstar, Alsip, IL, USA) to the nearest 0.1 kg and 0.1 cm, respectively. Multi-frequency bioelectrical impedance analysis (BIA) (InBody770, InBody, Cerritos, CA, USA) was used to determine body composition (percentage of body fat), as previously described (33).…”

Section: Methodsmentioning

confidence: 99%

Influence of muscle depth and thickness on ultrasound echo intensity of the vastus lateralis

et al. 2020

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Background Ultrasonography is used to evaluate muscle quality (i.e. echo intensity [EI]), but an attenuation of ultrasound waves occurs in deeper tissues, potentially affecting these measures. Purpose To determine whether muscle thickness (MT) affects EI and if EI varies between the superficial and deep portions of the muscle. Materials and Methods MT, EI, subcutaneous adipose tissue thickness (SAT), tissue depth (DISDEEP), and EI of the overall (EIFULL) as well as deep (EIDEEP) and superficial (EISUPF) portions of the vastus lateralis (VL) were assessed in 33 resistance-trained males using ultrasonography. The difference (EIDIFF) between EISUPF and EIDEEP was calculated. Mean differences between EIFULL, EISUPF, and EIDEEP were analyzed using a repeated-measures analysis of variance (ANOVA). Relationships between measures of muscle depth/ thickness and EI were examined using Pearson’s r. Results EISUPF was greater than EIDEEP ( P < 0.001) and EIFULL ( P < 0.001). MT was negatively correlated with EIFULL ( P < 0.001) and positively correlated with EIDIFF ( P < 0.001). SAT was not correlated with any EI measure, but DISDEEP was positively correlated with EIDIFF ( P < 0.001). Conclusion EI of the VL is heterogeneous, as the deeper portion produces lower values than the superficial portion. Thicker muscles present lower EI but have greater discrepancies in EI between the superficial and deep portions. Although SAT was not correlated with EI, DISDEEP was related to EIDIFF, demonstrating that the combination of MT and SAT should be considered when evaluating muscle quality. Future research is necessary to determine if changes in EI following resistance training are driven by increases in MT.

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“…Body mass (±0.1 kg) and height (±0.1 cm) were assessed using a Health-O-Meter Professional scale (Patient Weighing Scale, Model 500 KL, Pelstar, Alsip, IL, USA). Body composition (percent body fat, fat-free mass) was assessed via multi-frequency bioelectrical impedance analysis (BIA) machine (InBody770, InBody, Cerritos, CA), as previously described [39].…”

Section: Anthropometric and Body Composition Assessmentsmentioning

confidence: 99%

Effects of Rest Position on Morphology of the Vastus Lateralis and Its Relationship with Lower-Body Strength and Power

Varanoske

Coker

Johnson

et al. 2019

JFMK

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Ultrasonography of the lower body typically encompasses supine rest due to fluid shifts affecting tissue size and composition. However, vastus lateralis (VL) examination is completed in the lateral recumbent position, and this positional change may influence morphology and its ability to predict function. This study aimed to examine the effect of position on VL morphology and its relationship with lower-body performance. Cross-sectional area (CSA), muscle thickness (MT), pennation angle (PA), echo intensity (UnCorEI), subcutaneous adipose tissue thickness (SFT), and echo intensity corrected for SFT (CorEI) were assessed in 31 resistance-trained males (23.0 ± 2.1 yrs; 1.79 ± 0.08 m; 87.4 ± 11.7 kg) immediately after transitioning from standing to supine (IP), after 15 min of standing (ST), and after 15 min of rest in three recumbent positions: supine (SUP), dominant lateral recumbent (DLR), non-dominant lateral recumbent (NDLR). Participants also completed unilateral vertical jumps, isometric/isokinetic tests, and a one-repetition maximum leg press. CSA, MT, PA, and SFT were greater in ST compared to NDLR, DLR, and SUP (p < 0.05). CSA, UnCorEI, and CorEI were different between recumbent positions; however no differences were observed for MT, PA, and SFT. Different magnitudes of relationships were observed between muscle morphological characteristics measured after rest in different positions and performance variables. Muscle morphology in IP generally appears to be the best predictor of performance for most variables, although utilizing the NDLR and DLR positions may provide comparable results, whereas morphology measured in ST and SUP provide weaker relationships with physical performance. IP also requires less time and fewer requirements on the technician and subject, thus researchers should consider this positioning for VL examination.

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Tumor necrosis factor-alpha and soluble TNF-alpha receptor responses in young vs. middle-aged males following eccentric exercise

Cited by 15 publications

References 34 publications

The Effect of Orally Dosed Levagen+™ (palmitoylethanolamide) on Exercise Recovery in Healthy Males—A Double-Blind, Randomized, Placebo-Controlled Study

The Effect of Orally Dosed Levagen+™ (palmitoylethanolamide) on Exercise Recovery in Healthy Males—A Double-Blind, Randomized, Placebo-Controlled Study

Influence of muscle depth and thickness on ultrasound echo intensity of the vastus lateralis

Effects of Rest Position on Morphology of the Vastus Lateralis and Its Relationship with Lower-Body Strength and Power

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