Tumor necrosis factor alpha –C850T polymorphism is significantly associated with endometriosis in Asian Indian women

Lakshmi, Dr. Kodati Vijaya; Shetty, Preetha J; Vottam, Kiran; Govindhan, Sujatha; Ahmad, S.N.; Hasan, Qurratulain

doi:10.1016/j.fertnstert.2009.03.020

Cited by 16 publications

(4 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For further analysis, 54 full text articles were obtained. After thorough evaluation, 17 studies were found to be repeated in the database (Hsieh et al., ; Wieser et al., , ; Asghar et al., ; Teramoto et al., ; Bhanoori et al., ; Kitawaki et al., ; Zhao et al., ; Chae et al., ; Lee et al., ; Lu et al., ; Hank Juo et al., ; Chae et al., ; Vijaya Lakshmi et al., ; Mao et al., , ), 10 did not provide the raw data of TNF‐α/IL‐6 polymorphism that we needed for statistical analysis, and these studies reported specificity and sensitivity without the exact counts (Teramoto et al., ; Luo & He, ; Zhang et al., ; Chae et al., ; Lu et al., ; Zhang et al., ; Hank Juo et al., ; Zhou et al., ; Zhao et al., ; Kim et al., ), six studies were excluded because of duplication of data (Luo et al., , b; ; Zhou et al., , b; Mao et al., ), one was not a study of the human (Zhen et al., ), and three studies were on Caucasians (Wieser et al., , ; Zhao et al., ). Finally, 17 studies were selected (Hsieh et al., ; Lee et al., ; Asghar et al., ; Bhanoori et al., ; Kitawaki et al., ; Luo et al., ; Wang et al., ; Lee et al., ; Chae et al., ; Che et al., , b; Vijaya Lakshmi et al., ; Zeng et al., ; Mao et al., ; Zeng & Huang, ; Mao et al., ) (Fig.…”

Section: Resultsmentioning

confidence: 99%

Tumor Necrosis Factor and Interleukin‐6 Gene Polymorphisms and Endometriosis Risk in Asians: A Systematic Review and Meta‐Analysis

Chen

Wei

et al. 2013

Annals of Human Genetics

View full text Add to dashboard Cite

Summary A relationship between endometriosis and tumor necrosis factor (TNF‐α) and interleukin‐6 (IL‐6) gene polymorphisms has been raised for Asians. However, this topic is controversial. This study was a meta‐analysis to explore whether TNF‐α/IL‐6 gene polymorphisms were associated with a risk of endometriosis in Asians. By searching PubMed, HuGENet, and China National Knowledge Infrastructure (CNKI) databases, 17 studies were identified and included (3372 cases and 4008 controls). The odds ratio (OR) with 95% confidence interval (CI) was used to assess the association between TNF‐α/IL‐6 gene polymorphisms and endometriosis risk. An association of TNF‐α gene ‐1031T/C polymorphism with endometriosis was found (TT + TC vs. CC: OR 0.50, 95% CI 0.30–0.82, I2 = 37.1%, P = 0.20; TT vs. CC: OR 0.50, 95% CI 0.30–0.82, I2 = 43.0%, P = 0.173; TC vs. CC: OR 0.49, 95% CI 0.29–0.83, I2 = 10.6%, P = 0.327). In addition, TNF‐α‐238A/G and IL‐6 ‐174C/G gene polymorphisms were also likely to be associated with endometriosis in Asians. For the TNF‐α‐238A/G gene polymorphism, the OR was 1.577 (95% CI: 1.01–2.48). For the IL‐6 ‐174C/G gene polymorphism, the OR was 1.554 (95% CI: 1.04–2.31). No associations were detected between the TNF‐α‐308A/G and IL‐6 ‐634C/G polymorphisms and susceptibility to endometriosis. Our results indicate that the TNF‐α gene ‐1031T/C polymorphism can reduce the risk of endometriosis, but for Asians, TNF‐α‐238A/G and IL‐6 ‐174C/G gene polymorphisms may be a risk factor for endometriosis. No association was found for the TNF‐α‐308A/G and IL‐6 ‐634C/G gene polymorphisms.

show abstract

Section: Resultsmentioning

confidence: 99%

Tumor Necrosis Factor and Interleukin‐6 Gene Polymorphisms and Endometriosis Risk in Asians: A Systematic Review and Meta‐Analysis

Chen

Wei

et al. 2013

Annals of Human Genetics

View full text Add to dashboard Cite

show abstract

“…However, other data provided by another group [103] point out that the frequencies of the TNF α T/C/C haplotype allele and the TNFR2 G/G/T haplotype allele are significantly decreased in women with endometriosis compared to women without endometriosis, thus associating these haplotype alleles and polymorphisms to the disease. Moreover, an Indian population study [104] suggests an association between TNF α -C850T polymorphism and endometriosis.…”

Section: Immune Disturbance Of the Peritoneal Microenvironmentmentioning

confidence: 99%

Interplay between Misplaced Müllerian-Derived Stem Cells and Peritoneal Immune Dysregulation in the Pathogenesis of Endometriosis

Laganà

Sturlese

Retto

et al. 2013

Obstetrics and Gynecology International

View full text Add to dashboard Cite

In the genetic regulation of Müllerian structures development, a key role is played by Hoxa and Wnt clusters, because they lead the transcription of different genes according to the different phases of the organogenesis, addressing correctly cell-to-cell interactions, allowing, finally, the physiologic morphogenesis. Accumulating evidence is suggesting that dysregulation of Wnt and/or Hox genes may affect cell migration during organogenesis and differentiation of Müllerian structures of the female reproductive tract, with possible dislocation and dissemination of primordial endometrial stem cells in ectopic regions, which have high plasticity to differentiation. We hypothesize that during postpubertal age, under the influence of different stimuli, these misplaced and quiescent ectopic endometrial cells could acquire new phenotype, biological functions, and immunogenicity. So, these kinds of cells may differentiate, specializing in epithelium, glands, and stroma to form a functional ectopic endometrial tissue. This may provoke a breakdown in the peritoneal cavity homeostasis, with the consequent processes of immune alteration, documented by peripheral mononuclear cells recruitment and secretion of inflammatory cytokines in early phases and of angiogenic and fibrogenic cytokines in the late stages of the disease.

show abstract

“…Third, the retrieved publications were from only several countries within East Asia (Japan, Taiwan, Korea, and China). Although we also found some available data from India[545556575859] (South Asia), epidemiology-related researches from other Asian countries remains sparse. Fourth, probably because of the difficulties of epidemiologic studies, the level of evidence for lifestyle research may not be strong enough.…”

Section: Discussionmentioning

confidence: 94%

Epidemiologic factors associated with endometriosis in East Asia

Yen

Kim

Lee

2019

Gynecol Minim Invasive Ther

View full text Add to dashboard Cite

Aim:With a perplexing pathogenesis and an incidence rate of approximately 10% among women of reproductive age, endometriosis affects more women in Asia than in any other continent in the world. This paper reviews the available data on the epidemiology and risk factors associated with endometriosis in East Asia.Methods:Included studies were published between January 2000 and December 2016. Articles were required to include East Asian patients with a diagnosis of endometriosis and to study epidemiology, such as the prevalence and/or incidence, associated with inherited, environmental, and/or lifestyle factors. A total of 65 candidate articles were retrieved and 22 were included in the final review.Results:Only one study provided an estimate of prevalence (6.8%). Short menstrual cycle, family history of endometriosis, and some genetic polymorphisms are associated with the risk of developing endometriosis. Smoking, lower body mass index, and lower parity associated with increased risk of endometriosis were suggested as modifiable factors. Limitations of this study include the poor quality of data identified, and the language barriers behind the study retrieval.Conclusions:Data on the epidemiology of endometriosis in the East Asian populations are limited. The available data that examine potential genetic factors do not unveil whether such factors directly contribute to the increased risk of endometriosis. Further extensive studies on endometriosis in Asian women are required to improve the management of this disease.

show abstract

Tumor necrosis factor alpha –C850T polymorphism is significantly associated with endometriosis in Asian Indian women

Cited by 16 publications

References 25 publications

Tumor Necrosis Factor and Interleukin‐6 Gene Polymorphisms and Endometriosis Risk in Asians: A Systematic Review and Meta‐Analysis

Tumor Necrosis Factor and Interleukin‐6 Gene Polymorphisms and Endometriosis Risk in Asians: A Systematic Review and Meta‐Analysis

Interplay between Misplaced Müllerian-Derived Stem Cells and Peritoneal Immune Dysregulation in the Pathogenesis of Endometriosis

Epidemiologic factors associated with endometriosis in East Asia

Contact Info

Product

Resources

About