Tumor Necrosis Factor-<i>α</i> T-857C (rs1799724) Polymorphism and Risk of Cancers: A Meta-Analysis

Wang, Ping; Wang, June; Mu, Yu; Li, Zhiqiang

doi:10.1155/2016/4580323

Cited by 21 publications

(13 citation statements)

References 41 publications

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“…The haplotypic frequencies of the other genes showed no statistically significant difference between the groups. In the TNF gene, the TCG haplotype (rs1799964, rs1799724, and rs361525, respectively) contained risk alleles associated with low TNF expression [ 15 , 16 , 17 , 18 ]. The frequency of this haplotype was compared between cases and controls, but there was no statistically significant difference.…”

Section: Resultsmentioning

confidence: 99%

Association between Genetic Variants in NOS2 and TNF Genes with Congenital Zika Syndrome and Severe Microcephaly

Gomes

Sgarioni

Boquett

et al. 2021

Viruses

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Zika virus (ZIKV) causes Congenital Zika Syndrome (CZS) in individuals exposed prenatally. Here, we investigated polymorphisms in VEGFA, PTGS2, NOS3, TNF, and NOS2 genes as risk factors to CZS. Forty children with CZS and forty-eight children who were in utero exposed to ZIKV infection, but born without congenital anomalies, were evaluated. Children with CZS were predominantly infected by ZIKV in the first trimester (p < 0.001) and had mothers with lower educational level (p < 0.001) and family income (p < 0.001). We found higher risk of CZS due the allele rs2297518[A] of NOS2 (OR = 2.28, CI 95% 1.17–4.50, p = 0.015). T allele and TT/CT genotypes of the TNF rs1799724 and haplotypes associated with higher expression of TNF were more prevalent in children with CZS and severe microcephaly (p = 0.029, p = 0.041 and p = 0.030, respectively). Our findings showed higher risk of CZS due ZIKV infection in the first trimester and suggested that polymorphisms in NOS2 and TNF genes affect the risk of CZS and severe microcephaly.

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Section: Resultsmentioning

confidence: 99%

Association between Genetic Variants in NOS2 and TNF Genes with Congenital Zika Syndrome and Severe Microcephaly

Gomes

Sgarioni

Boquett

et al. 2021

Viruses

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“…Additionally, Cen and Wu [25] and Wang et al [26] both showed that TNF-α -857 C/T polymorphism is significantly associated with increased risk of GC. However, TNF-α -1031 and TNF-α -863 polymorphisms have neither the meta-analysis, they were just reported in signal case–control: Hamajima et al [27] found -1031CC was not only related with reduced items, such as sex, age, but also low seropositivity.…”

Section: Introductionmentioning

confidence: 99%

An updated association between TNF-α -238G/A polymorphism and gastric cancer susceptibility in East Asians

Zhao

Liu

et al. 2018

Bioscience Reports

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Polymorphisms in the tumor necrosis factor α (TNF-α) gene are emerging as key determinants of gastric diseases. The TNF-α-238G/A single-nucleotide polymorphism (SNP) is the most extensively studied. However, this association is inconsistent amongst different populations. We therefore conducted an updated meta-analysis to obtain a more precise estimate of the association of TNF-α-238G/A polymorphism with gastric cancer (GC) risk. A comprehensive search of PubMed, Embase, Chinese (CNKI and WanFang) databases was performed to identify relevant studies through 5 May 2018. Odds ratio (OR) and 95% confidence interval (CI) were used to assess the strength of the association. Fourteen studies were included in our meta-analysis involving 2999 cases and 4685 controls. There was no significant association between TNF-α-238G/A polymorphism and GC risk in the overall populations. In the subgroup analysis, we found that TNF-α-238G/A polymorphism was associated with the increased risk of GC amongst Asians, especially in Chinese, but not in Caucasians. Subgroup analysis by genotyping methods revealed increased risk for other methods. In conclusion, our present meta-analysis shows that TNF-α-238G/A polymorphism is associated with the risk of GC in East Asian individuals.

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“…Heidari, Moudi, Mahmoudzadeh Sagheb, and Moudi () also found that the TNF‐α rs1799724 CC/CT genotypes are associated with susceptibility to HBV infection in a South East Iranian Population. A meta‐analysis of 5,215 cases and 6,755 controls reported that the TNF‐α rs1799724 polymorphism could increase HCC risk in homozygote and recessive genetic models in Asian, Caucasian and African populations (Wang, Wang, Yu, & Li, ). However, in this study, we did not find an association between rs1799724 and HCC in a Chinese Han population.…”

Section: Discussionmentioning

confidence: 99%

Association of hepatocellular carcinoma risk with polymorphisms in tumour necrosis factor alpha gene in a Chinese Han population

Yue

Jiang

Zou

et al. 2020

Int J Immunogenetics

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Hepatocellular carcinoma (HCC) is the third leading cause of cancer‐related death worldwide. Studies have shown that the tumour necrosis factor alpha (TNF‐α) plays an important role in the development of HCC; however, the association between genetic variations of TNF‐α and HCC is not yet fully understood. To evaluate the correlation of TNF‐α polymorphisms with HCC, we randomly selected 327 HCC patients and 432 healthy controls, all these subjects reported Han nationality. Genotyping of four TNF‐α SNPs (rs1799724, rs1800629, rs1799964 and rs1800610) was performed using the matrix‐assisted laser desorption ionization‐time of flight mass spectrometry (MALDI‐TOF‐MS) method. Distributions of rs1799964 genotypes and rs1800610 alleles were found to be significantly different between cases and controls (p = .011, p = .001). The recessive model of rs1799964 significantly increased HCC risk (p = .0015), while the dominant and over‐dominant models of rs1800610 significantly reduced HCC risk (p = .0096, p = .014). Haplotype analysis of the four TNF‐α SNPs revealed that the TGTA haplotype was associated with a reduced HCC risk (p = .0033, OR = 0.53), while the TGTG haplotype was associated with an increased HCC risk (p = .0032, OR = 9.69). These findings indicated that specific TNF‐α polymorphisms may be associated with the susceptibility to HCC.

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Tumor Necrosis Factor-α T-857C (rs1799724) Polymorphism and Risk of Cancers: A Meta-Analysis

Cited by 21 publications

References 41 publications

Association between Genetic Variants in NOS2 and TNF Genes with Congenital Zika Syndrome and Severe Microcephaly

Association between Genetic Variants in NOS2 and TNF Genes with Congenital Zika Syndrome and Severe Microcephaly

An updated association between TNF-α -238G/A polymorphism and gastric cancer susceptibility in East Asians

Association of hepatocellular carcinoma risk with polymorphisms in tumour necrosis factor alpha gene in a Chinese Han population

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