Association of hepatocellular carcinoma risk with polymorphisms in tumour necrosis factor alpha gene in a Chinese Han population

Abstract

Hepatocellular carcinoma (HCC) is the third leading cause of cancer‐related death worldwide. Studies have shown that the tumour necrosis factor alpha (TNF‐α) plays an important role in the development of HCC; however, the association between genetic variations of TNF‐α and HCC is not yet fully understood. To evaluate the correlation of TNF‐α polymorphisms with HCC, we randomly selected 327 HCC patients and 432 healthy controls, all these subjects reported Han nationality. Genotyping of four TNF‐α SNPs (rs1799724, rs1800629, rs1799964 and rs1800610) was performed using the matrix‐assisted laser desorption ionization‐time of flight mass spectrometry (MALDI‐TOF‐MS) method. Distributions of rs1799964 genotypes and rs1800610 alleles were found to be significantly different between cases and controls (p = .011, p = .001). The recessive model of rs1799964 significantly increased HCC risk (p = .0015), while the dominant and over‐dominant models of rs1800610 significantly reduced HCC risk (p = .0096, p = .014). Haplotype analysis of the four TNF‐α SNPs revealed that the TGTA haplotype was associated with a reduced HCC risk (p = .0033, OR = 0.53), while the TGTG haplotype was associated with an increased HCC risk (p = .0032, OR = 9.69). These findings indicated that specific TNF‐α polymorphisms may be associated with the susceptibility to HCC.

The Relationship between Metabolic Syndrome and Plasma Metals Modified by EGFR and TNF-α Gene Polymorphisms

“…Our finding showed that the heterozygous genotypes of EGFR rs11977660 T > C, rs3823585 C > G, and rs3735061 G > A appeared to be more susceptible to higher plasma Se concentration, while TNF-α rs1800610 AA genotype played a protective role. In prior studies, TNF-α rs1800610 GA and AA genotypes were associated with a reduced risk in hepatocellular carcinoma [ 50 ], and AA genotype was observed to protect against rheumatoid arthritis [ 51 ], so we supposed that TNF-α rs1800610 AA might be a protective genotype in some pathogeneses. Pb was a toxic metal, but its association with MetS was not consistent [ 6 , 8 ].…”

A Network Pharmacology Approach to Explore the Potential Mechanisms of Huangqin-Baishao Herb Pair in Treatment of Cancer

“…Tumor necrosis factor (TNF) mediates a variety of cell processes such as inflammation, differentiation, proliferation, and apoptosis. Clinical evidence shows that TNF polymorphisms are associated with susceptibility to cancer, including hepatocellular carcinoma [25], multiple myeloma [26], cervical cancer [27], and colorectal cancer [28]. Tryptophan (Trp) is an essential amino acid that is obtained exclusively from diet and is used for the production of neurotransmitters and neuromodulators.…”