Tumor Necrosis Factor-Like Weak Inducer of Apoptosis and Selected Cytokines—Potential Biomarkers in Children with Solitary Functioning Kidney

Nosek, Hanna; Jankowska, Dorota; Brzozowska, Karolina; Kazberuk, Katarzyna; Wasilewska, Anna; Taranta-Janusz, Katarzyna

doi:10.3390/jcm10030497

Cited by 3 publications

(2 citation statements)

References 31 publications

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“…In our analysis, the prevalence of hypertension was 8.8%, while in previous studies in children with SFK, the number of hypertensive patients ranged from 13 to 26% [ 25 , 35 ]. In the KIMONO study by Westland et al, the authors concluded that an SFK from childhood implies a substantial risk for hypertension [ 20 ].…”

Section: Discussioncontrasting

confidence: 56%

Galectin-3—A New Player of Kidney Damage or an Innocent Bystander in Children with a Single Kidney?

Latoch

Konończuk

Jander

et al. 2021

JCM

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The aim of this study was to evaluate the galectin-3 (Gal-3) level in children with a congenital solitary functioning kidney (cSFK) and determine its association with common renal function parameters. The study consisted of 68 children (49 males) with cSFK. We demonstrated that children with cSFK had a lower level of galectin-3 than that of healthy subjects (p < 0.001). No significant differences in serum cystatin C (Cys C) levels between the cSFK children and the reference group were found. The subjects with cSFK and reduced estimated glomerular filtration rate (eGFR) had significantly higher levels of Gal-3 and Cys C compared to those with normal eGFR (p < 0.05). Children with eGFR <60 mL/min/1.73 m2 showed significant statistical differences between the values of area under ROC curve (AUC) for Gal-3 (AUC 0.91) and Cys C (AUC 0.96) compared to that for creatinine level (AUC 0.76). Similar analyses carried out among cSFK children with eGFR <90 mL/min/1.73 m2 revealed an AUC value of 0.69 for Gal-3, 0.74 for Cys C, and 0.64 for creatinine; however, no significant superiority was shown for any of them. The receiver operating characteristic (ROC) analyses for identifying the SFK children among all participants based on the serum levels of Gal-3 and Cys C did not show any diagnostic profile (AUCs for Gal-3 and Cys C were 0.22 and 0.59, respectively). A positive correlation between the Gal-3 and Cys C concentrations was found (r = 0.39, p = 0.001). We demonstrated for the first time that Gal-3 might play an important role in the subtle kidney damage in children with cSFK. However, further prospective studies are required to confirm the potential applicability of Gal-3 as an early biomarker for kidney injury and possible progression to CKD.

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Section: Discussioncontrasting

confidence: 56%

Galectin-3—A New Player of Kidney Damage or an Innocent Bystander in Children with a Single Kidney?

Latoch

Konończuk

Jander

et al. 2021

JCM

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“…It may be detected by using the antibody M30. Cleavage of various caspases can be detected using flow cytometry during apoptosis [28,29]. The widely used biomarkers of apoptosis, their methods of analysis and the specimen needed for analysis are discussed in Table 2.…”

Section: Bio Markers Of Apoptosismentioning

confidence: 99%

Insights into the Role of Defective Apoptosis in Cancer Pathogenesis and Therapy

Thapa¹,

Rather²,

Singh³

et al. 2022

Regulation and Dysfunction of Apoptosis

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One form of programmed cell death (PCD) is apoptosis. Defective apoptosis is an indispensable causative factor in the development of cancer that allows cancer cells to survive longer and favors the accumulation of oncogenic mutations. Further, upregulation of antiapoptotic proteins (e.g., Bcl-2, Mcl-1) and loss of pro-apoptotic proteins (e.g., Bid, Bad, Bax, Bak) strongly favors apoptosis evasion. The ability of cancer cells to evade apoptosis is critical for the progression and clonal expansion of malignantly transformed cells. Defective apoptosis imparts proliferative advantage to cancer cells or cells with the potential to become cancerous. The mechanisms employed by cancer cells to evade apoptosis can be used in the strategic design of therapeutic regimens aimed at exploiting apoptotic signaling networks to ensure tumor-specific cell death. Therefore, to ensure tumor-specific cell death, we may need to exploit the expression and/or function of different components of apoptotic signaling that are critical for maintaining cell survival and are regulated differently in tumor cells than normal cells. Both inhibitors of anti-apoptotic proteins and activators of pro-apoptotic proteins can be used for cancer therapy. In this chapter, we attempted to summarize the knowledge about the molecular mechanisms of defective apoptosis that could be translated into the development of novel therapeutic agents and therapeutic modalities for cancer treatment.

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Protein Biomarkers in Chronic Kidney Disease in Children—What Do We Know So Far?

Szumińska

Wasilewska

Kamianowska

2023

JCM

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Chronic kidney disease (CKD) in children is a major concern of medical care and public health as it is related to high morbidity and mortality due to progression to end-stage kidney disease (ESKD). It is essential to identify patients with a risk of developing CKD to implement therapeutic interventions. Unfortunately, conventional markers of CKD, such as serum creatinine, glomerular filtration rate (GFR) and proteinuria, have many limitations in serving as an early and specific diagnostic tool for this condition. Despite the above, they are still the most frequently utilized as we do not have better. Studies from the last decade identified multiple CKD blood and urine protein biomarkers but mostly assessed the adult population. This article outlines some recent achievements and new perspectives in finding a set of protein biomarkers that might improve our ability to prognose CKD progression in children, monitor the response to treatment, or even become a potential therapeutic target.

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Tumor Necrosis Factor-Like Weak Inducer of Apoptosis and Selected Cytokines—Potential Biomarkers in Children with Solitary Functioning Kidney

Cited by 3 publications

References 31 publications

Galectin-3—A New Player of Kidney Damage or an Innocent Bystander in Children with a Single Kidney?

Galectin-3—A New Player of Kidney Damage or an Innocent Bystander in Children with a Single Kidney?

Insights into the Role of Defective Apoptosis in Cancer Pathogenesis and Therapy

Protein Biomarkers in Chronic Kidney Disease in Children—What Do We Know So Far?

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