Tumor Necrosis Factor, Natural Killer Activity and Other Measures of Immune Function and Inflammation in Elderly Men with Heart Failure

Pritchett, Genie; Cohen, Harvey Jay; Rao, Min; Cobb, F. R.; Sullivan, Mike; Currie, Mark S.

doi:10.1159/000213661

Cited by 13 publications

(6 citation statements)

References 22 publications

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“…TNF-was measured by ELISA in 16 patients, and all had at least one sample with no detectable TNF-. Other studies have failed to show a significant increase in TNFconcentration in CCF [12], possibly due to be the patients being relatively old. In the present study, only two patients were under 60 years of age.…”

Section: Discussionmentioning

confidence: 88%

Cytokine profile in chronic cardiac failure

Steele¹,

Nugent²,

Maguire³

et al. 1996

Eur J Clin Investigation

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Elevated tumour necrosis factor alpha (TNF-alpha) has been demonstrated in chronic cardiac failure (CCF) and may relate to severity of CCF and development of cachexia. We measured TNF receptor p55 in addition to TNF-alpha in an attempt to improve the detection rate of TNF-alpha activation, and simultaneously measured interleukin 6 (IL-6), interleukin 8 (IL-8) and C-reactive protein. Thirty-four patients with CCF and 24 control subjects were studied. Only TNF receptor p55 [6.95 (0.77-42.3) vs. 5.52 (1.50-13.36) ng mL-1 (median (range)] and IL-6 [0.335 (0-9.79) vs. 0(0-14.71) pg mL-1) were significantly elevated in patients compared with control subjects (both P < 0.05). All inflammatory markers were more frequently elevated in patients, but none correlated with any of the clinical parameters studied. Reasons for inflammatory marker elevation in CCF are uncertain, but future studies should measure the p55 TNF receptor and IL-6 in addition to TNF-alpha, to improve detection of cytokine activity.

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Section: Discussionmentioning

confidence: 88%

Cytokine profile in chronic cardiac failure

Steele¹,

Nugent²,

Maguire³

et al. 1996

Eur J Clin Investigation

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“…Several studies have shown that CHF is associated with activation of the immune system 7,8,18–25 . However, whether this immune activation is responsible for, or a result of, impaired cardiac function is to a large degree unknown.…”

Section: Discussionmentioning

confidence: 99%

Anti‐Inflammatory Effect of Cardiac Resynchronization Therapy

Lappegård

Bjørnstad

2006

Pacing Clinical Electrophis

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“…In the present study, we observed elevated levels of this cytokine only in 6.9% of patients; this result is similar to that reported by van Riemsdijk-van Overbeeke et al 31 , who failed to detect serum levels of free TNFα in HF patients notwithstanding their finding of elevated levels of TNFα soluble receptors with increased binding capacity, which explained the low TNFα bioavailability. Additionally, no change in the levels of this cytokine when compared to control healthy individuals was reported in two other studies done in patients with mild or moderate heart failure [32][33] .…”

Section: Discussionmentioning

confidence: 75%

Prevalence of Trypanosoma cruzi antibodies and inflammatory markers in uncompensated heart failure

Bravo-Tobar

Parra²,

Pérez

et al. 2011

Rev. Soc. Bras. Med. Trop.

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Introduction: Heart failure (HF) represents the final stage of chronic chagasic cardiomyopathy (CChC). The diagnosis of CChC is based on the demonstration of anti-Trypanosoma cruzi antibodies (aTcAg) and clinical and epidemiological data. In Venezuela, there are no data about the prevalence of chagasic HF. The aim of this study was to determine the epidemiological, clinical, and inflammatory risk factors associated with seronegative or seropositive HF patients. Methods: We performed a cross-sectional study in the Venezuelan central-west states among a healthy rural population and in patients admitted to the emergency room with uncompensated HF. Results: The seroprevalence rates of Trypanosoma cruzi antibodies were 11.2% and 40.1% in the healthy population and in HF patients, respectively. Seropositivity in healthy individuals was associated with age, knowledge on triatomine vectors, and having seen wild reservoirs in the house; in HF patients, with contact with the vector and previous clinical diagnosis of Chagas' disease; and in both groups taken together, with age, knowledge on triatomines, and HF. Seropositive patients had prolonged QRS, decreased ejection fraction, and high serum magnesium, all significant as compared with HF seronegative cases. Left atrium enlargement and ventricular hypertrophy were most frequently observed in HF seronegative patients. CRP, IL6, ILβ1, IL2, and FNTα were elevated in 94.5%, 48%, 17.8%, 13.7%, and 6.9% of HF patients, respectively, but only IL2 levels were associated with chagasic HF. Conclusions: There is a high prevalence of aTcAg in HF patients from the central-west region of Venezuela, and their epidemiological, clinical, and inflammatory features are discreetly different as compared with those of seronegative cases.

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Tumor Necrosis Factor, Natural Killer Activity and Other Measures of Immune Function and Inflammation in Elderly Men with Heart Failure

Cited by 13 publications

References 22 publications

Cytokine profile in chronic cardiac failure

Cytokine profile in chronic cardiac failure

Anti‐Inflammatory Effect of Cardiac Resynchronization Therapy

Prevalence of Trypanosoma cruzi antibodies and inflammatory markers in uncompensated heart failure

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