Tumor necrosis factor-α and interleukin-1β gene polymorphisms and risk of brain abscess in North Indian population

Tumor necrosis factor α‐308 G/A and interleukin 1 β‐511 C/T gene polymorphisms in patients with scarring acne

“…The polymorphic variants of IL‐1α at +4845 and −889 locuses were found to be associated with acne severity. Interleukin 1β is another important proinflammatory cytokine mainly released from activated T lymphocytes and macrophages . The polymorphic variants of IL‐1β‐511 were detected in brain abscess, chronic periodontitis, and major recurrent depression .…”

“…18 The polymorphic variants of IL-1b-511 were detected in brain abscess, chronic periodontitis, and major recurrent depression. 18,25,26 Recent researches about acne pathogenesis point to the role of IL-1b pathways which are stimulated by P. acnes. 7,8 Interleukin 1b mRNA and activated processed IL-1b were measured to be densely accumulated in inflammatory acne lesions.…”

“…Interleukin 1β is another important proinflammatory cytokine mainly released from activated T lymphocytes and macrophages . The polymorphic variants of IL‐1β‐511 were detected in brain abscess, chronic periodontitis, and major recurrent depression . Recent researches about acne pathogenesis point to the role of IL‐1β pathways which are stimulated by P. acnes .…”

“…The polymorphic variants of TNF α‐308 are suggested to be associated with acne formation in different populations . The increase in C allele amount (C<T) in the ‐511 locus of IL‐1β leads oversecretion of IL‐1β cytokine . When searched, we could not find any report about the association of IL‐1β polymorphisms with acne.…”

“…[11][12][13][14][15][16][17] The increase in C allele amount (C<T) in the -511 locus of IL-1b leads oversecretion of IL-1b cytokine. 18 When searched, we could not find any report about the association of IL-1b polymorphisms with acne. Therefore, in this study, we hypothesized that genotypic variant involving -308 locus of TNF a gene and -511 locus of IL-1b may be associated with acne, acne severity, and scarring acne.…”