Tumor necrosis factor-α in immune-mediated demyelination and Wallerian degeneration of the rat peripheral nervous system

Stoll, Guido; Jung, Stefan; Jander, Sebastian; Meide, Peter van der; Hartung, Hans‐Peter

doi:10.1016/0165-5728(93)90178-2

Cited by 152 publications

(91 citation statements)

References 35 publications

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“…In addition, TNFα induces other chemotactic factors, such as monocyte chemoattractant protein-1 (MCP-1) (Subang and Richardson, 2001). It is interesting to note that TNFα is expressed only by pre-phagocytic macrophages (Stoll et al, 1993) and that TNFα deletion reduces macrophage influx without affecting their phagocytic capacity (Liefner et al, 2000). MMP-9 ability to promote macrophage migration after TNFα deletion also suggests that, after being induced by TNFα, MMP-9 promotes macrophage migration independent of TNFα.…”

Section: Discussionmentioning

confidence: 99%

TNFα-induced MMP-9 promotes macrophage recruitment into injured peripheral nerve

Shubayev

Angert

Dolkas

et al. 2006

Molecular and Cellular Neuroscience

148

152

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Matrix metalloproteinase-9 (MMP-9) is an extracellular protease that is induced hours after injury to peripheral nerve. This study shows that MMP-9 gene deletion and neutralization with MMP-9 antibody reduce macrophage content in injured wild-type nerves. In mice with delayed Wallerian degeneration (Wld S ), MMP-9 and tumor necrosis factor alpha (TNFα) decline in association with the reduced macrophage recruitment to injured nerve that characterizes this strain of mice. We further determined that TNFα acts as an MMP-9 inducer by establishing increased MMP-9 levels after TNFα injection in rat sciatic nerve in vivo and primary Schwann cells in vitro. We found reduced MMP-9 expression in crushed TNFα knockout nerves that was rescued with exogenous TNFα. Finally, local application of MMP-9 on TNFα−/− nerves increased macrophage recruitment to the lesion. These data suggest that TNFα lies upstream of MMP-9 in the pathway of macrophage recruitment to injured peripheral nerve.

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Section: Discussionmentioning

confidence: 99%

TNFα-induced MMP-9 promotes macrophage recruitment into injured peripheral nerve

Shubayev

Angert

Dolkas

et al. 2006

Molecular and Cellular Neuroscience

148

152

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“…Schwann cells play key roles in neuroimmune responses such as cytokine production in peripheral nerves (Berg-steinsdottir et al, 1991;Hirota et al, 1996;Wagner and Myers, 1996;Murwani and Armati, 1998). While macrophages are certainly needed for successful regeneration (Brown et al, 1991), Stoll et al (1993) report that only pre-phagocytic macrophages in nerves undergoing Wallerian degeneration are immunoreactive for TNF-α.…”

Section: Discussionmentioning

confidence: 99%

Increase in inflammatory cytokines in median nerves in a rat model of repetitive motion injury

Alshatti¹,

Barr²,

Safadi³

et al. 2005

Journal of Neuroimmunology

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We examined cytokines in rat median nerves following performance of a high repetition reaching and grasping task at a rate of 8 reaches/min for up to 8 weeks. IL-1α, IL-1β, TNF-α, IL-6 and IL-10 were analyzed by immunohistochemistry. Double-labeling immunohistochemistry for ED1, a marker of phagocytic macrophages, was also performed. We found increased immunoexpression of IL-6 by week 3, increases in all 5 cytokines by week 5. This response was transient as all cytokines returned to control levels by 8 weeks of performance of a high repetition negligible force task. Cytokine sources included Schwann cells, fibroblasts and phagocytic macrophages (ED1-immunopositive). These findings suggest that cytokines are involved in the pathophysiology of repetitive motion injuries in peripheral nerves.

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“…It is noteworthy that production of these potent macrophage activators occurs at the site where such activation may play a key role in the demyelination associated with HSV-1 infection in the CNS (Townsend, 1981). Indeed, TNF-α itself may have a direct involvement in demyelination through its toxicity for oligodendrocytes (Stoll et al, 1993).…”

Section: Discussionmentioning

confidence: 99%

Cytokine production in the nervous system of mice during acute and latent infection with herpes simplex virus type 1.

Shimeld

Whiteland

Williams

et al. 1997

Journal of General Virology

101

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Tumor necrosis factor-α in immune-mediated demyelination and Wallerian degeneration of the rat peripheral nervous system

Cited by 152 publications

References 35 publications

TNFα-induced MMP-9 promotes macrophage recruitment into injured peripheral nerve

TNFα-induced MMP-9 promotes macrophage recruitment into injured peripheral nerve

Increase in inflammatory cytokines in median nerves in a rat model of repetitive motion injury

Cytokine production in the nervous system of mice during acute and latent infection with herpes simplex virus type 1.

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