Tumor-related leukocytosis is linked with poor prognosis in patients with lung carcinoma

Kasuga, Ikuma; Makino, Seiya; Kiyokawa, Hiroshi; Katoh, Harubumi; Ebihara, Yoshiro; Ohyashiki, Kazuma

doi:10.1002/1097-0142(20011101)92:9<2399::aid-cncr1588>3.0.co;2-w

Cited by 203 publications

(164 citation statements)

References 25 publications

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“…Anaemia in the context of a malignancy predicts a poor outcome ( (Langer et al, 2002). Leucocytosis is thought to be due to overproduction of granulocyte colony stimulating factor (Kasuga et al, 2001). Tumour related leucocytosis is associated with poor prognosis compared to patients without leucocytosis.…”

Section: Discussionmentioning

confidence: 99%

Clinico-Pathological Profile and Haematological Abnormalities Associated with Lung Cancer in Bangalore, India

Bhatnagar

Narayanswamy²

2016

Asian Pacific Journal of Cancer Prevention

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Background: Lung cancer is one of the most common types of cancer causing high morbidity and mortality worldwide. An increasing incidence of lung cancer has been observed in India. Objectives:To evaluate the clinicpathological profile and haematological abnormalities associated with lung cancer in Bangalore, India. Materials and Methods: This prospective study was carried out over a period of 2 years. A total of 96 newly diagnosed and histopathologically confirmed cases of lung cancer were included in the study. Results: Our lung cancer cases had a male to female ratio of 3:1. Distribution of age varied from 40 to 90 years, with a major contribution in the age group between 61 and 80 years (55.2%). Smoking was the commonest risk factor found in 69.7% of patients. The most frequent symptom was cough (86.4%) followed by loss of weight and appetite (65.6%) and dyspnea (64.5%). The most common radiological presentation was a mass lesion (55%). The most common histopathological type was squamous cell carcinoma (47.9%), followed by adenocarcinoma (28.1%) and small cell carcinoma (12.5%). Distant metastasis at presentation was seen in 53.1% patients. Among the haematological abnormalities, anaemia was seen in 61.4% of patients, leucocytosis in 36.4%, thrombocytosis in 14.5% and eosinophilia in 19.7% of patients. Haematological abnormalities were more commonly seen in non small cell lung cancer. Conclusions: Squamous cell carcinoma was found to be the most common histopathological type and smoking still remains the major risk factor for lung cancer. Haematological abnormalities are frequently observed in lung cancer patients, anaemia being the commonest of all.

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Section: Discussionmentioning

confidence: 99%

Clinico-Pathological Profile and Haematological Abnormalities Associated with Lung Cancer in Bangalore, India

Bhatnagar

Narayanswamy²

2016

Asian Pacific Journal of Cancer Prevention

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“…It is possible that neutrophils and their activation by IL-6 together with several cytokines play a crucial role in the pathogenesis of ANCA-negative, as well as ANCA-positive, CrGN. Conversely, some kinds of lung cancer are known to produce IL-6 [9][10][11]. In these IL-6-producing cancers, IL-6 plays a pivotal role in paraneoplastic manifestations, such as fever, general fatigue, and anemia [10,11].…”

Section: Introductionmentioning

confidence: 99%

AP-VAS 2012 case report: a case of ANCA-negative pauci-immune crescentic glomerulonephritis associated with IL-6-producing adenosquamous cell carcinoma of the lung

et al. 2013

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A 76-year-old man with lung cancer and multiple metastases was admitted for purpura and rapidly progressive glomerulonephritis. Adenosquamous cell carcinoma of the lung had been diagnosed 6 months earlier.Two anti-cancer drug regimens had no effect. At admission, his survival with his malignancy was estimated to be several months. Renal biopsy revealed pauci-immune necrotizing crescentic glomerulonephritis (CrGN). Negative results were obtained for myeloperoxidase-anti-neutrophil cytoplasmic antibody (ANCA) and proteinase-3-ANCA by enzyme-linked immunosorbent assay, and for peripheral-ANCA and cytoplasmic-ANCA by indirect immunofluorescence. He was diagnosed with ANCA-negative pauciimmune CrGN. Although steroids were initiated, the patient died of renal failure and intestinal bleeding 2 weeks later. It was later found that cancer cells were positive for interleukin (IL)-6 and that serum IL-6 levels were significantly elevated, concomitantly with increased IL-8, granulocyte-colony stimulating factor and transforming growth factor-b levels. Some kinds of lung cancer are known to produce IL-6 that activate neutrophils and are related to ANCA-associated CrGN. It appears that IL-6 can activate neutrophils in the pathogenesis of ANCA-negative pauciimmune CrGN with lung cancer. Therapy that blocks IL-6 may prove to be effective in vasculitis and cancer-related symptoms in such cases.

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“…The frequency of tumor related leucocytosis was highest in large cell group compared with adeno and squamous group (54.5%, 11.7% and 20% respectively). 16 In our study, although the number of patients with large cell carcinoma was small, the frequency of tumor related leucocytosis was also highest in large cell group (75%). However no association was found between any histopathological subtype and pretreatment WBC levels (p= 0.387).…”

Section: Discussionmentioning

confidence: 41%

The Effect of Haematological Parameters on Overall Survival in Advanced Stage Non Small Cell Lung Cancer.

Oğuz¹

2014

UHOD

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Tumor-related leukocytosis is linked with poor prognosis in patients with lung carcinoma

Cited by 203 publications

References 25 publications

Clinico-Pathological Profile and Haematological Abnormalities Associated with Lung Cancer in Bangalore, India

Clinico-Pathological Profile and Haematological Abnormalities Associated with Lung Cancer in Bangalore, India

AP-VAS 2012 case report: a case of ANCA-negative pauci-immune crescentic glomerulonephritis associated with IL-6-producing adenosquamous cell carcinoma of the lung

The Effect of Haematological Parameters on Overall Survival in Advanced Stage Non Small Cell Lung Cancer.

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