Tumor Responsive and Tunable Polymeric Platform for Optimized Delivery of Paclitaxel to Treat Glioblastoma

Graham-Gurysh, Elizabeth G.; Moore, Kathryn M.; Schorzman, Allison N.; Lee, Taek; Zamboni, William C.; Hingtgen, Shawn; Bachelder, Eric M.

doi:10.1021/acsami.0c04102

Cited by 36 publications

(42 citation statements)

References 61 publications

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“…The polymer used resulted in substantially different PTX release speeds, which are strongly associated with scaffold degradation. Only a trace amount of PTX was liberated In-vitro from PLA scaffolds, which is congruous with literature, where release trials were conducted in the absence of proteinase [72] .…”

Section: Electrospun Nanofibrous Drug Delivery System For Chemotherapysupporting

confidence: 72%

A review on allopathic and herbal nanofibrous drug delivery vehicles for cancer treatments

Mateti

Aswath

Vatti

et al. 2021

Biotechnology Reports

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Highlights The life-threatening side effects of cancer treatment are addressed using nano-formulations and combinational therapy. Herbal drugs displayed potency in curing cancer using a nanofiber based device. Allopathic anti-cancer drugs can be delivered at a targeted site using a nanofiber based drug carrier which improves bioavailability to a great extent. A combination of an herbal and allopathic anticancer drug could be a possible life-saving union to cure cancer.

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Section: Electrospun Nanofibrous Drug Delivery System For Chemotherapysupporting

confidence: 72%

A review on allopathic and herbal nanofibrous drug delivery vehicles for cancer treatments

Mateti

Aswath

Vatti

et al. 2021

Biotechnology Reports

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“… 4 , 10 , 11 Among these methods, electrospinning has been consolidated as a simple, versatile and cost-effective technique to produce ultrathin and nanofibers from a wide range of polymers. 12 , 13 Because of its intrinsic high porosity and interconnectivity, electrospun fibers have been the target of many applications in the biomedical field, including drug delivery, 14 , 15 tissue engineering, 10 , 11 , 14 and wound dressing. 16 − 18 …”

Section: Introductionmentioning

confidence: 99%

Curcuminoid-Tailored Interfacial Free Energy of Hydrophobic Fibers for Enhanced Biological Properties

Deus

França

Forero

et al. 2021

ACS Appl. Mater. Interfaces

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The ability of mimicking the extracellular matrix architecture has gained electrospun scaffolds a prominent space into the tissue engineering field. The high surface-to-volume aspect ratio of nanofibers increases their bioactivity while enhancing the bonding strength with the host tissue. Over the years, numerous polyesters, such as poly(lactic acid) (PLA), have been consolidated as excellent matrices for biomedical applications. However, this class of polymers usually has a high hydrophobic character, which limits cell attachment and proliferation, and therefore decreases biological interactions. In this way, functionalization of polyester-based materials is often performed in order to modify their interfacial free energy and achieve more hydrophilic surfaces. Herein, we report the preparation, characterization, and in vitro assessment of electrospun PLA fibers with low contents (0.1 wt %) of different curcuminoids featuring π-conjugated systems, and a central β-diketone unit, including curcumin itself. We evaluated the potential of these materials for photochemical and biomedical purposes. For this, we investigated their optical properties, water contact angle, and surface features while assessing their in vitro behavior using SH-SY5Y cells. Our results demonstrate the successful generation of homogeneous and defect-free fluorescent fibers, which are noncytotoxic, exhibit enhanced hydrophilicity, and as such greater cell adhesion and proliferation toward neuroblastoma cells. The unexpected tailoring of the scaffolds’ interfacial free energy has been associated with the strong interactions between the PLA hydrophobic sites and the nonpolar groups from curcuminoids, which indicate its role for releasing hydrophilic sites from both parts. This investigation reveals a straightforward approach to produce photoluminescent 3D-scaffolds with enhanced biological properties by using a polymer that is essentially hydrophobic combined with the low contents of photoactive and multifunctional curcuminoids

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“…This approach enabled faster degradation upon exposure to the lower pH conditions associated with the tumor, releasing more PTX in vivo and resulting in higher antitumor activity as compared to nonacid-sensitive scaffolds. [60] While initial efforts on the design of stimuli-responsive local treatments was centered around chemotherapy delivery, their focus has recently shifted to the modulation of the TME using chemoimmunotherapy combinations as well as immunotherapy. Several recent reviews provide detailed and comprehensive descriptions of different engineered implantable (and injectable) materials developed for this purpose.…”

Section: Programmable Polymeric Biomolecular and Biohybrid Implantable Sprayable And Wearable/transdermal Materials For Localized Cancer mentioning

confidence: 99%

Innovations in Disease State Responsive Soft Materials for Targeting Extracellular Stimuli Associated with Cancer, Cardiovascular Disease, Diabetes, and Beyond

2021

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along with locally applied materials have been developed to respond to biological signals for safer and more efficacious therapeutics delivery.At the small molecule level, the concept of programmable functional groups has been exploited for many years in the form of simple prodrugs. With this approach, drugs are chemically modified to inactive forms and then undergo programmed enzymatic or chemical transformations as a response to metabolic or physical and chemical signals to expose the active functionalities at the target site in vivo. [1] This strategy often enhances the solubility, reduces the toxicity and improves the bioavailability of the parent drug. [1] As an example, sulfasalazine, a disease-modifying antirheumatic drug, relies on bacterial metabolism in the colon to cleave the azo linkage and release the active sulfapyridine and 5-aminosalicylic acid. [2] This concept has been more recently adapted at the nano-and micrometer scale in the development of more complex materials. The resulting programmable responsive systems are a class of materials capable of dynamic transitions and function as a response to one or multiple triggers. While many materials have been designed to respond to exogenous, or applied stimuli such as light, ultrasound, and magnetic fields, [3] or to intracellular low pH or reductive environments, [3a,b,4] responsive nanomedicine and materials that are able to recognize signals associated with specific disease states remain relatively underdeveloped. Such approaches offer extraordinary opportunities for reducing off-target effects and enhancing therapeutic indices. In the development of pathologies, diseased tissues exhibit specific biological features, which can be classified as physical, chemical, and biomolecular differentiators that are associated with the disease state. Common disease-associated physical cues include changes in pressure (shear force) [5] and permeability. [6] Chemical hallmarks can involve changes in pH and redox state. [7] Biomolecular features can be extracellular (upregulated enzymes and biomolecule production) [8] and intracellular (adenosine triphosphate and nucleic acids, among others). [9] Such markers help to differentiate diseased from healthy tissues and are useful in the design of diseasetargeted programmable materials.Recent advances in polymer chemistry, materials sciences, and biotechnology have allowed the preclinical development of sophisticated programmable nanomedicines and materials that are able to precisely respond to specific disease-associated triggers and microenvironments. These stimuli, endogenous to the targeted diseases, include pH, redox-state, small molecules, and protein upregulation. Herein, recent advances and innovative approaches in programmable soft materials capable of sensing the aforementioned disease-associated stimuli and responding via a range of dynamic processes including morphological and size transitions, changes in mobility and retention, as well as disassembly are described. In this field generally, the majority...

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Tumor Responsive and Tunable Polymeric Platform for Optimized Delivery of Paclitaxel to Treat Glioblastoma

Cited by 36 publications

References 61 publications

A review on allopathic and herbal nanofibrous drug delivery vehicles for cancer treatments

A review on allopathic and herbal nanofibrous drug delivery vehicles for cancer treatments

Curcuminoid-Tailored Interfacial Free Energy of Hydrophobic Fibers for Enhanced Biological Properties

Innovations in Disease State Responsive Soft Materials for Targeting Extracellular Stimuli Associated with Cancer, Cardiovascular Disease, Diabetes, and Beyond

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