Tumor selective uptake of drug-nanodiamond complexes improves therapeutic outcome in pancreatic cancer

Madamsetty, Vijay Sagar; Sharma, Anil Kumar; Toma, Maria Alexandra; Samaniego, Stefanie; Gallud, Audrey; Wang, Enfeng; Pal, Krishnendu; Mukhopadhyay, Debabrata; Fadeel, Bengt

doi:10.1016/j.nano.2019.02.020

Cited by 35 publications

(29 citation statements)

References 40 publications

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“…Another study of Madamsetty et al showed the remarkable anti-tumor efficacy of PEGylated nanodiamonds carrying a dual payload of irinotecan (a derivate of camptothecin that inhibits the action of topoisomerase I) plus curcumin. These results highlight the potential use of such nano-carriers in the treatment of patients with pancreatic cancer [ 145 ].…”

Section: Natural Products and Drug Delivery In Oncologymentioning

confidence: 96%

Drug Delivery Systems of Natural Products in Oncology

Colone¹,

Calcabrini²,

Stringaro³

2020

Molecules

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In recent decades, increasing interest in the use of natural products in anticancer therapy field has been observed, mainly due to unsolved drug-resistance problems. The antitumoral effect of natural compounds involving different signaling pathways and cellular mechanisms has been largely demonstrated in in vitro and in vivo studies. The encapsulation of natural products into different delivery systems may lead to a significant enhancement of their anticancer efficacy by increasing in vivo stability and bioavailability, reducing side adverse effects and improving target-specific activity. This review will focus on research studies related to nanostructured systems containing natural compounds for new drug delivery tools in anticancer therapies.

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Section: Natural Products and Drug Delivery In Oncologymentioning

confidence: 96%

Drug Delivery Systems of Natural Products in Oncology

Colone¹,

Calcabrini²,

Stringaro³

2020

Molecules

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“…Similarly, PEG functionalized ND was loaded on DOX to provide solutions for curing pancreatic cancer, and it was suggested that PEG-ND-DOX drug system might improve the therapeutic outcome of pancreatic ductal adenocarcinoma. Moreover, ND composites with PEG have higher retention rates as compared to DOX alone (Madamsetty et al, 2019).…”

Section: Drug Deliverymentioning

confidence: 98%

“…Moreover, ND composites with PEG have higher retention rates as compared to DOX alone(Madamsetty et al, 2019).These applications suggest that ND/biocompatible polymer composites are primarily used as a carrier for chemotherapy. Similarly, PEG functionalized ND was loaded on DOX to provide solutions for curing pancreatic cancer, and it was suggested that PEG-ND-DOX drug system might improve the therapeutic outcome of pancreatic ductal adenocarcinoma.…”

mentioning

confidence: 99%

Nanodiamond in composite: Biomedical application

Rehman

Houshyar

Wang

2020

J Biomedical Materials Res

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The biocompatibility of materials is the determining factor for them to be applied in biomedical areas. Nanodiamond (ND) has gained increasing interest in this area due to its biocompatibility, ease of surface functionalization and excellent mechanical performance. ND has been widely used to reinforce biopolymers, and the resultant biocomposites have found applications in bone tissue engineering, chemotherapeutic drug delivery, and wound healing. Fluorescent ND, when combined with biopolymers, is serving for bioimaging and sensing applications. Herein, we contribute a description of ND, recent trends in its adoption for biopolymers, functionalization methods, amalgamation techniques of ND with biopolymers, potential applications of these composites in the biomedical field and future perspectives.biocompatibility, biocomposites, biopolymers, nanodiamond, scaffold

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“…The most common modifications are PEG, poloxamers, polysaccharides, and other hydrophilic polymers. In the latter study, PEG-functionalized NDs loaded with DOX (ND-PEG-DOX) displayed excellent biocompatibility and prolonged drug retention in vivo [ 121 ]. According to Elechalawar et al, gold NPs were used for targeted delivery of GEM to PCCs with the monoclonal antibody cetuximab (C225) as the targeting ligand for EGFR and PEG as a stealth molecule.…”

Section: Application and Clinical Trials Of Nanocarrier-based Thermentioning

confidence: 99%

Recent Progress of Nanocarrier-Based Therapy for Solid Malignancies

Wei

Lau

2020

Cancers

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Conventional chemotherapy is still an important option of cancer treatment, but it has poor cell selectivity, severe side effects, and drug resistance. Utilizing nanoparticles (NPs) to improve the therapeutic effect of chemotherapeutic drugs has been highlighted in recent years. Nanotechnology dramatically changed the face of oncology by high loading capacity, less toxicity, targeted delivery of drugs, increased uptake to target sites, and optimized pharmacokinetic patterns of traditional drugs. At present, research is being envisaged in the field of novel nano-pharmaceutical design, such as liposome, polymer NPs, bio-NPs, and inorganic NPs, so as to make chemotherapy effective and long-lasting. Till now, a number of studies have been conducted using a wide range of nanocarriers for the treatment of solid tumors including lung, breast, pancreas, brain, and liver. To provide a reference for the further application of chemodrug-loaded nanoformulations, this review gives an overview of the recent development of nanocarriers, and the updated status of their use in the treatment of several solid tumors.

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Tumor selective uptake of drug-nanodiamond complexes improves therapeutic outcome in pancreatic cancer

Cited by 35 publications

References 40 publications

Drug Delivery Systems of Natural Products in Oncology

Drug Delivery Systems of Natural Products in Oncology

Nanodiamond in composite: Biomedical application

Recent Progress of Nanocarrier-Based Therapy for Solid Malignancies

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