Tumor size matters differently in pulmonary adenocarcinoma and squamous cell carcinoma

Yang

2011

Chin. J. Cancer Res.

Objective: To identify clinical and pathologic factors that were associated with the survival of stage IB upper lobe non-small cell lung cancer (NSCLC) patients.Methods: A retrospective study of 147 subjects who had undergone curative resection for stage IB upper lobe NSCLC was performed. Patients who had received any adjuvant or neo-adjuvant chemotherapy were excluded. Survival function curves were estimated using the Kaplan-Meier procedure. Crude and adjusted hazard ratios (HRs) of potential prognostic factors were estimated using Cox proportional hazards models.Results: Five factors, including age, tumor size, histologic grade of differentiation, number of removed superior mediastinal lymph node stations and presence of visceral pleura invasion, were significantly and independently associated with mortality risk. Adjusted HRs were 2.6 [95% confidence interval (95% CI): 1.1−6.5] and 4.6 (95% CI: 1.9−11) for those aged 58−68 years and those >68 years, respectively, relative to those aged <58 years. HRs for those with poorly and moderately differentiated tumors were 6.4 (95% CI: 2.3−18) and 1.4 (95% CI: 0.7−2.8), respectively. HRs for those with tumor size 3.1−5 cm and >5 cm (vs ≤3.0 cm) were 2.3 (95% CI: 1.1−4.9) and 4.3 (95% CI: 1.9−10), respectively. The presence of visceral pleura invasion also increased the risk of mortality (HR=4.0, 95% CI: 1.3−12).Conclusion: Advanced age, larger tumor size, poorly differentiated histology, smaller number of removed superior mediastinal lymph node stations, and presence of visceral pleura invasion were associated with poor survival of surgically treated stage IB upper lobe NSCLC patients.

Section: Discussionmentioning

confidence: 99%

Prognostic factors for survival of stage IB upper lobe non-small cell lung cancer patients: A retrospective study in Shanghai, China

Yang

2011

Chin. J. Cancer Res.

“…Metastasis of lung cancer can occur, even when the primary tumor is still small. Therefore, patients with advanced LUAD have a poor prognosis, with an average 5-year survival rate of less than 20% [ 9 , 10 , 11 , 12 ]. Further research on new therapeutic targets for LUAD is essential.…”

Section: Introductionmentioning

confidence: 99%

Oncogenic EFNA4 Amplification Promotes Lung Adenocarcinoma Lymph Node Metastasis

Zhao

Chen

Sun

et al. 2022

Cancers

Lymph nodes metastases are common in patients with lung cancer. Additionally, those patients are often at a higher risk for death from lung tumor than those with tumor-free lymph nodes. Somatic DNA alterations are key drivers of cancer, and copy number alterations (CNAs) are major types of DNA alteration that promote lung cancer progression. Here, we performed genome-wide DNA copy number analysis, and identified a novel lung-cancer-metastasis-related gene, EFNA4. The EFNA4 genome locus was significantly amplified, and EFNA4 mRNA expression was significantly up-regulated in lung cancer compared with normal lung tissue, and also in lung cancer with lymph node metastases compared with lung cancer without metastasis. EFNA4 encodes Ephrin A4, which is the ligand for Eph receptors. The function of EFNA4 in human lung cancer remains largely unknown. Through cell line experiments we showed that EFNA4 overexpression contributes to lung tumor cells growth, migration and adhesion. Conversely, EFNA4 knockdown or knockout led to the growth suppression of cells and tumor xenografts in mice. Lung cancer patients with EFNA4 overexpression have poor prognosis. Together, by elucidating a new layer of the role of EFNA4 in tumor proliferation and migration, our study demonstrates a better understanding of the function of the significantly amplified and overexpressed gene EFNA4 in lung tumor metastasis, and suggests EFNA4 as a potential target in metastatic lung cancer therapy.

“…Lin ve ark. [24] 4 cm'den küçük primer tümörler değerlendirildiğinde adenokarsinomda, 2.5 cm'in nodal ve uzak metastaz artışı ile ilgili kritik eşik değer boyutu olduğunu göstermiştir (p<0.001). Bu ilişki skuamöz hücreli kanserde saptanmamıştır (p>0.05).…”

Section: Discussionunclassified

Relationship of T-stage and nodal metastases according to the up-to-date clinical TNM staging in lung cancer

Yılmaz¹

2012

Turk Gogus Kalp Dama