Tumor Size Significantly Correlates with Postoperative Liver Metastases and COX-2 Expression in Patients with Resectable Pancreatic Cancer

Matsumoto, Gaku; Muta, Mariko; Takada, Koji; Horiguchi, Shinichiro; Kiura, Katsuyuki; Okamoto, Akira

doi:10.1159/000104241

Cited by 17 publications

(9 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Pancreatic cancer [120,121] Anaplastic pancreatic cancer [122] Tumor COX-2 expression portends a poor prognosis for patients with resected adenocarcinoma of the pancreas, particularly in tumors > or = 3 cm [121]. Expression of L1CAM, COX-2, and EGFR in the majority of undifferentiated pancreatic carcinomas [122].…”

Section: Tissue Location and Type Of Cancer Correlation With Other Bimentioning

confidence: 99%

Targeting Lipid Peroxidation for Cancer Treatment

et al. 2020

View full text Add to dashboard Cite

Cancer is one of the highest prevalent diseases in humans. The chances of surviving cancer and its prognosis are very dependent on the affected tissue, body location, and stage at which the disease is diagnosed. Researchers and pharmaceutical companies worldwide are pursuing many attempts to look for compounds to treat this malignancy. Most of the current strategies to fight cancer implicate the use of compounds acting on DNA damage checkpoints, non-receptor tyrosine kinases activities, regulators of the hedgehog signaling pathways, and metabolic adaptations placed in cancer. In the last decade, the finding of a lipid peroxidation increase linked to 15-lipoxygenases isoform 1 (15-LOX-1) activity stimulation has been found in specific successful treatments against cancer. This discovery contrasts with the production of other lipid oxidation signatures generated by stimulation of other lipoxygenases such as 5-LOX and 12-LOX, and cyclooxygenase (COX-2) activities, which have been suggested as cancer biomarkers and which inhibitors present anti-tumoral and antiproliferative activities. These findings support the previously proposed role of lipid hydroperoxides and their metabolites as cancer cell mediators. Depletion or promotion of lipid peroxidation is generally related to a specific production source associated with a cancer stage or tissue in which cancer originates. This review highlights the potential therapeutical use of chemical derivatives to stimulate or block specific cellular routes to generate lipid hydroperoxides to treat this disease.

show abstract

Section: Tissue Location and Type Of Cancer Correlation With Other Bimentioning

confidence: 99%

Targeting Lipid Peroxidation for Cancer Treatment

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Moreover, OS and PFS were poor in patients with a large GTV in the present study, and some past studies showed that tumor size was a prognostic factor in CRT and surgery for pancreatic cancer. [32][33][34] Those results indicate that it may be better to perform IFRT by dose escalation for LAPC with a large tumor size.…”

Section: Discussionmentioning

confidence: 93%

How Much Was the Elective Lymph Node Region Covered in Involved-Field Radiation Therapy for Locally Advanced Pancreatic Cancer? Evaluation of Overlap Between Gross Target Volume and Celiac Artery–Superior Mesenteric Artery Lymph Node Regions

Umezawa

Ito

Wakita

et al. 2020

Advances in Radiation Oncology

View full text Add to dashboard Cite

Purpose: The purpose of this study was to investigate the overlaps between gross target volume (GTV) and the celiac artery (CA) and superior mesenteric artery (SMA) lymph node regions and to examine the dose incidentally irradiated to the CA and SMA lymph node regions by involved-field radiation therapy (IFRT) for locally advanced pancreatic cancer (LAPC). Methods and Materials: Fifty-nine patients who had LAPC without distant metastasis were included. They received IFRT at 50.4 Gy in 28 fractions with 3-dimensional conformal radiation therapy. We calculated the percentages of overlap of GTV in the CA and SMA lymph node regions and examined what cases tend to have an overlap. We also investigated the dose metrics of CA and SMA lymph node regions by IFRT and the frequency of CA or SMA lymph node metastasis after IFRT. Results: The median GTV volume was 52.2 mL. Median overlap percentages in the CA and SMA lymph node regions were 39.2% and 28.6%, respectively. There was a significant correlation between GTV volume and SMA overlap percentage (P < .001). Although the SMA overlap percentage was higher in the pancreas head (P Z .028), the CA overlap percentage was higher in the pancreas body or tail (P Z .002). Median mean dose, D95, and minimum dose in the CA lymph node region were 50.1 Gy, 48.7 Gy, and 45.9 Gy, respectively, and those in the SMA lymph node region 49.9 Gy, 47.3 Gy, and 39.2 Gy, respectively. CA lymph node metastases after IFRT were detected in 4 patients (6.8%).

show abstract

“…As tumors in the resection group are grown to a larger size, they may exhibit confounding variables outside of those induced by surgical trauma alone. For example, larger tumors could be associated with higher levels of vascular endothelial growth factor (VEGF) and other angiogenic or resistance factors that could independently alter PDT outcomes, as well as be characterized by increased deposition of extracellular matrix and greater numbers of fibroblasts [38–41]. In addition, the degree of immune infiltrate to the tumor may be different in larger versus smaller tumors due to prolonged exposure to the adaptive immune system in tumors grown over longer times [42].…”

Section: Resultsmentioning

confidence: 99%

A preclinical model to investigate the role of surgically‐induced inflammation in tumor responses to intraoperative photodynamic therapy

et al. 2018

View full text Add to dashboard Cite

The tumor incision model induces IL-6 release as is seen in the surgical setting, yet it avoids the limitations of surgical resection models. Potential mechanisms by which surgical induction of inflammation and IL-6 could alter the nature and efficacy of tumor response to PDT are reviewed. These include a wide spectrum of molecular and cellular mechanisms through which surgically-induced IL-6 could change the effectiveness of therapies that are combined with surgery. The tumor incision model can be employed for novel investigations of the effects of surgically-induced, acute inflammation on therapeutic response to PDT (or potentially other therapies). Lasers Surg. Med. 50:440-450, 2018. © 2018 Wiley Periodicals, Inc.

show abstract

Tumor Size Significantly Correlates with Postoperative Liver Metastases and COX-2 Expression in Patients with Resectable Pancreatic Cancer

Cited by 17 publications

References 36 publications

Targeting Lipid Peroxidation for Cancer Treatment

Targeting Lipid Peroxidation for Cancer Treatment

How Much Was the Elective Lymph Node Region Covered in Involved-Field Radiation Therapy for Locally Advanced Pancreatic Cancer? Evaluation of Overlap Between Gross Target Volume and Celiac Artery–Superior Mesenteric Artery Lymph Node Regions

A preclinical model to investigate the role of surgically‐induced inflammation in tumor responses to intraoperative photodynamic therapy

Contact Info

Product

Resources

About