Tumor thickness as a predictive factor of lymph node metastasis and disease recurrence in T1N0 and T2N0 squamous cell carcinoma of the oral tongue

Risk factors for salvage surgery failure in oral cavity squamous cell carcinoma

“…However, to our knowledge, this is the first study to evaluate tumor thickness and its influence on the overall survival rates of patients with recurrent oral cavity cancers. Other publications from our group showed that a tumor thickness >7 mm in the oral cavity was associated with a higher incidence of lymph node metastasis, and that lesions >10 mm were associated with shorter disease‐free survival . The cutoff value of 10 mm for tumor thickness as a risk factor for shorter survival rates also reflects the results from our previously reported series .…”

“…The cutoff value of 10 mm for tumor thickness as a risk factor for shorter survival rates also reflects the results from our previously reported series . Matos et al identified 10 mm as the cutoff value for short disease‐free survival in SCC of the oral tongue with T1/T2N0 and for short disease‐free survival of less than 12 months in a cohort of patients with SCC of the oral cavity who underwent the first surgical approach with free surgical margins . In the present study, a tumor thickness of 10 mm or more in a relapse was associated with a shorter overall survival rate ( P = .034).…”

Tumor volume as an independent predictive factor of worse survival in patients with oral cavity squamous cell carcinoma

“…This reflects the challenge of obtaining free margins when operating on high‐volume tumors that are not confined by cartilaginous or osseous boundaries . However, margin positivity was not a predictor of recurrence or death, even on univariate analysis, as well as other features usually associated with poor prognosis, such as angiolymphatic invasion and lymph node extracapsular spread, were also not relevant prognostic factors in the present study, as demonstrated in other studies by our group …”

Risk Factors for Distant Metastasis in Patients with Oral Cavity Squamous Cell Carcinoma Undergoing Surgical Treatment

“…Tumor thickness is a variable that has recently been included in the list of risk factors for worse prognosis in patients with OCSCC, along with a higher incidence of lymph node metastasis, locoregional recurrences, and mortality [16, 17]. However, its association with the development of distant metastases has not been studied.…”