Tumor-to-tumor metastasis of diffuse large B cell lymphoma to gastric adenocarcinoma via CXCL12 (SDF-1)/CXCR4 axis: a case report

Kamihara, Yusuke; Murai, Sayaka; Kikuchi, Shohei; Wada, Akinori; Murakami, Jun; Dang, Nam H.; Sato, Tsutomu

doi:10.1186/s12876-021-01844-z

Cited by 6 publications

(1 citation statement)

References 11 publications

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“…CXCR4 encodes a CXC chemokine receptor specific to stromal cell-derived factor-1, which has seven transmembrane regions and is located on the cell surface. The cases studied by Kamihara et al [42] indicated that CXCL12 (SDF-1)/CXCR4 axis is involved in the observed Computational and Mathematical Methods in Medicine metastasis of diffuse large B cell lymphoma to primary STAD and considered that the interaction between chemokines and their receptors may be the potential mechanism of the observed metastasis between tumors. IL6 encodes a cytokine that plays a role in inflammation and B cell maturation.…”

Section: Discussionmentioning

confidence: 99%

Comprehensive Analysis of the Immune Implication of AKAP12 in Stomach Adenocarcinoma

Ling

Peng

et al. 2022

Computational and Mathematical Methods in Medicine

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A kinase anchor protein 12 (AKAP12) as a tumor suppressor in various cancers has been extensively studied and confirmed. However, its immune implication in stomach adenocarcinoma (STAD) remains uncertain. Here, using The Cancer Genome Atlas (TCGA), Human Protein Atlas (HPA), Tumor Immune Estimation Resource (TIMER), Cancer Cell Line Encyclopedia (CCLE), integrated repository portal for tumor-immune system interactions (TISIDB), and Search Tool for the Retrieval of Interaction Gene/Proteins (STRING) database, we systematically analyzed the immune correlation of AKAP12 from three aspects including immune infiltration cells, immune-related pathways, and immunomodulators and developed a AKAP12-related 4-gene signature for prognosis prediction. Our results showed that AKAP12 mRNA and protein levels were downregulated in STAD patients, and its expression was positively related to CD4+ T cells and macrophages. In addition, the immune cell infiltration levels were associated with AKAP12 gene copy number deletion in STAD. Based on CCLE database, we found that AKAP12 coexpressed genes were enriched in several immune- and cancer-related pathways, which was further validated by Gene Set Enrichment Analysis (GSEA). Moreover, we identified 46 immunomodulators that were significantly related to AKAP12 expression using TISIDB database, and these immunomodulators were involved in immune-related pathways including Th17 cell differentiation and natural killer cell-mediated cytotoxicity. Additionally, based on the 46 AKAP12-related immunomodulators, a 4-gene risk prediction signature was developed using the Cox regression model. The risk signature was identified as an independent prognostic factor, which can accurately predict the prognosis of patients with STAD, showing good predictive performance. Furthermore, we constructed a prognostic nomogram and calibration to predict and assess patient survival probabilities by integrating the risk score and other clinical factors. In conclusion, our study provides strong evidence that AKAP12 is closely related to tumor immunity in STAD from three aspects: immune infiltration cells, immune pathways, and immunomodulators. More importantly, the AKAP12-related prognostic signature may have a good application prospect for clinical practice.

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Section: Discussionmentioning

confidence: 99%

Comprehensive Analysis of the Immune Implication of AKAP12 in Stomach Adenocarcinoma

Ling

Peng

et al. 2022

Computational and Mathematical Methods in Medicine

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Bone Marrow Mesenchymal Stem Cell (BMSC) Restrains the Angiogenesis in Melanoma Through Stromal-Derived-Factor-1/C-X-C Chemokine Receptor Type 4 (SDF-1/CXCR4)

Jiao

Yang

Miao

et al. 2022

j biomater tissue eng

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This study analyzes the effect of BMSC on restraining the angiogenesis in melanoma through inducing SDF-1/CXCR4 channel. 50 female naked rates were equally assigned into NC group, model group, BMSC group, agonist group and positive NC group randomly followed by analysis of pathological changes, and the level of HIF-1, VEG, MVD, SDF-1 and CXCR4. Agonist group showed the highest level of HIF-1α and VEGF and MVD followed by, model group BMSC group, positive NC group and NC group with no different between BMSC group and positive NC group. SDF-1 and CXCR4 expression was highest in agonist group, followed by that in model group, positive NC group, BMSC group and NC group without difference between model group and positive NC group. In conclusion, SDF-1/CXCR4 activity could be restrained by BMSC partly along with reduced level of HIF-1α and VEGF. This is mainly related with restraining the SDF-1/CXCR4 channel, indicating that it could be adopted as a brand-new therapeutic target for treating melanoma.

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Bone Marrow Mesenchymal Stem Cell (BMSC) Ameliorates the Damage of Inflammatory Bowel Disease (IBD) Rats Through Regulation of Stromal Cell-Derived Factor 1/C-X-C Chemokine Receptor Type 4 (SDF-1/CXCR4) Axis

Kang

2022

j biomater tissue eng

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This study assesses the effect and mechanism of BMSC in IBD rat. Fifty SDF-grade rats were assigned into divided into NC group, model group, BMSC group, blocking agent group and positive NC group randomly with 10 rates in each group. The histopathological changes of colon tissue, expression of Musashi-1, DAPI, SDF-1 and CXCR4 was measured. There was notable inflammatory cell infiltration in model group and agonist group. The structure of gland was destructed notably with notable-visible phenomenon of hyperemia and edema in colon tissue. They could be improved significantly in positive control group and BMSC group. The necrotic colonic mucosal tissue began to be recovered slowly. The phenomenon of hyperemia and edema was alleviated notably without abnormality in colon tissue in control group. The positive level of Musashi-1 in control group, model group and agonist group was the highest. In conclusion, BMSC could be migrated into colonic damage position and differentiated into intestine stem cells to exert recovery effect on IBD rats. The molecular mechanism might be related with SDF-1/CXCR4 axis.

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Tumor-to-tumor metastasis of diffuse large B cell lymphoma to gastric adenocarcinoma via CXCL12 (SDF-1)/CXCR4 axis: a case report

Cited by 6 publications

References 11 publications

Comprehensive Analysis of the Immune Implication of AKAP12 in Stomach Adenocarcinoma

Comprehensive Analysis of the Immune Implication of AKAP12 in Stomach Adenocarcinoma

Bone Marrow Mesenchymal Stem Cell (BMSC) Restrains the Angiogenesis in Melanoma Through Stromal-Derived-Factor-1/C-X-C Chemokine Receptor Type 4 (SDF-1/CXCR4)

Bone Marrow Mesenchymal Stem Cell (BMSC) Ameliorates the Damage of Inflammatory Bowel Disease (IBD) Rats Through Regulation of Stromal Cell-Derived Factor 1/C-X-C Chemokine Receptor Type 4 (SDF-1/CXCR4) Axis

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