Tumor vasculature vs tumor cell targeting: Understanding the latest trends in using functional nanoparticles for cancer treatment

Awad, Nahid S.; Salkho, Najla M; Abuwatfa, Waad H.; Paul, Vinod; AlSawaftah, Nour M.; Husseini, Ghaleb A.

doi:10.1016/j.onano.2023.100136

Cited by 12 publications

(6 citation statements)

References 204 publications

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“…With this targeted strategy, chemotherapy drugs can be delivered precisely, enhancing their accumulation at the tumor site while reducing their toxicity to healthy tissues. 164 Additionally, Green synthesized NPs enhance the stability, solubility, and bioavailability of anticancer drugs by encapsulating it. This avoids challenges related to conventional chemotherapy via enhancing drug efficacy, extended drug release pattern, and improved therapeutic outcomes.…”

Section: Biomedical Applications Of Green Synthesized Npsmentioning

confidence: 99%

Recent Advancements and Unexplored Biomedical Applications of Green Synthesized Ag and Au Nanoparticles: A Review

Ahmad,

Ali

et al. 2024

IJN

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Green synthesis of silver (Ag) and gold (Au) nanoparticles (NPs) has acquired huge popularity owing to their potential applications in various fields. A large number of research articles exist in the literature describing the green synthesis of Ag and Au NPs for biomedical applications. However, these findings are scattered, making it time-consuming for researchers to locate promising advancements in Ag and Au NPs synthesis and their unexplored biomedical applications. Unlike other review articles, this systematic study not only highlights recent advancements in the green synthesis of Ag and Au NPs but also explores their potential unexplored biomedical applications. The article discusses the various synthesis approaches for the green synthesis of Ag and Au NPs highlighting the emerging developments and novel strategies. Then, the article reviews the important biomedical applications of green synthesized Ag and Au NPs by critically evaluating the expected advantages. To expose future research direction in the field, the article describes the unexplored biomedical applications of the NPs. Finally, the articles discuss the challenges and limitations in the green synthesis of Ag and Au NPs and their biomedical applications. This article will serve as a valuable reference for researchers, working on green synthesis of Ag and Au NPs for biomedical applications.

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Section: Biomedical Applications Of Green Synthesized Npsmentioning

confidence: 99%

Recent Advancements and Unexplored Biomedical Applications of Green Synthesized Ag and Au Nanoparticles: A Review

Ahmad,

Ali

et al. 2024

IJN

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“…Malignant tumors develop due to mutations in the genetic and epigenetic structure, interrupting the natural cycle of cells, which involves cell division and apoptosis. [1][2][3] Treatments such as surgery, radiotherapy, and chemotherapy, while effective in many cases, come with side effects and impact the patient's quality of life. 4,5 Adaptations are being studied to make treatments more precise and less harmful, 6 along with new methods aiming to reduce exposure and treatment duration.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and characterization of magnetite coated by maltodextrin for application in magnetic hyperthermia

Bueno,

Naves,

Rosa

et al. 2024

New J. Chem.

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“…To enhance the selectivity of the liposomes to the targeted cancer cells, active targeting of tumors can be achieved by decorating the surface of the liposomes with different types of targeting ligands such as proteins, peptides, carbohydrates, and antibodies. These targeting ligands can bind to the overexpressed receptors located on the cancer cells' surface, thus minimizing the off-target effects [9][10][11].…”

Section: Introductionmentioning

confidence: 99%

Effect of Phospholipid Head Group on Ultrasound-triggered Drug Release and Cellular Uptake of Immunoliposomes

Awad

Paul

AlSawaftah

et al. 2023

Preprint

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Liposomes are the most successful nanoparticles used to date to load and deliver chemotherapeutic agents to cancer cells. They are nano-sized vesicles made up of phospholipids, and targeting moieties can be added to their surfaces for active targeting of specific tumors. Furthermore, Ultrasound can be used to trigger the release of the loaded drugs by disturbing their phospholipid bilayer structure. In this study, we have prepared pegylated liposomes using four types of phospholipids with similar saturated hydrocarbon tails and different head groups (DPPC and DPPA, DPPE, and DPPG). The prepared liposomes were conjugated to the monoclonal antibody trastuzumab (TRA) to target the human epidermal growth factor receptor 2 (HER2) overexpressed on HER2-positive cancer cells (HER2+). We have compared the response of the different formulations of liposomes when triggered with low-frequency ultrasound (LFUS) and their cellular uptake by the cancer cells. The results showed that the different formulations had similar size, polydispersity, and stability. TRA-conjugated DPPC liposomes showed the highest sensitivity to LFUS. On the other hand, incubating the cancer cells with TRA-conjugated DPPA liposomes triggered with LFUS showed the highest uptake of the loaded calcein by the HER2 + cells.

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Tumor vasculature vs tumor cell targeting: Understanding the latest trends in using functional nanoparticles for cancer treatment

Cited by 12 publications

References 204 publications

Recent Advancements and Unexplored Biomedical Applications of Green Synthesized Ag and Au Nanoparticles: A Review

Recent Advancements and Unexplored Biomedical Applications of Green Synthesized Ag and Au Nanoparticles: A Review

Synthesis and characterization of magnetite coated by maltodextrin for application in magnetic hyperthermia

Effect of Phospholipid Head Group on Ultrasound-triggered Drug Release and Cellular Uptake of Immunoliposomes

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