Tumor Volume in Pharyngolaryngeal Squamous Cell Carcinoma: Comparison at CT, MR Imaging, and FDG PET and Validation with Surgical Specimen

Daisne, Jean-François; Duprez, Thierry; Weynand, Birgit; Lonneux, Max; Hamoir, Marc; Reychler, Hervé; Grégoire, Vincent

doi:10.1148/radiol.2331030660

Cited by 622 publications

(421 citation statements)

References 18 publications

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“…Because of the good correlation between the MTV and the GTV assessed by other imaging tools such as CT [11,12], we can expected that MTV may be another important factor to be considered in the management of HNSCC. A study to compare CT, MRI, and FDG PET for delineation of tumor volume in pharyngolaryngeal squamous cell carcinoma with the results validated by surgical specimen indicated that FDG PET was the most accurate modality for measuring tumor volume [36].…”

Section: Discussionmentioning

confidence: 99%

Prognostic Value of Metabolic Tumor Volume Measured by 18F-FDG PET/CT in Locally Advanced Head and Neck Squamous Cell Carcinomas Treated by Surgery

Choi

Yoo

Han

et al. 2010

Nucl Med Mol Imaging

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Purpose We assessed the prognostic value of metabolic tumor volume (MTV) measured using 18 F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) inpatients with locally advanced head and neck squamous cell carcinoma (HNSCC). Methods We retrospectively reviewed 56 patients (51 men, five women; mean age 56.0±8.8years) who had locally advanced HNSCC and underwent FDG PET/CT for initial evaluation. All patients had surgical resection and radiotherapy with or without concurrent chemotherapy. The peak standardized uptake value (SUV peak ) and MTV of the target lesion, including primary HNSCC andmetastatic cervical lymph nodes, were measured from FDG PET/CT images. We compared SUV peak , MTV, and clinicopathologic variables such as age, Eastern Cooperative Oncology Group (ECOG) performance status, pN stage, pT stage, TNM stage, histologic grade and treatment modality to disease-free survival (DFS) and overall survival (OS). Results On the initial FDG PET/CT scans, the median SUV peak was 7.8 (range, 1.8-19.0) and MTV was17.0 cm 3 (range, 0.1-131.0 cm 3 ). The estimated 2-year DFS and OS rates were 67.2% and 81.8%. The cutoff points of SUV peak 6.2 and MTV 20.7 cm 3 were the best discriminative values for predicting clinical outcome. MTV and ECOG performance status were significantly related to DFS and OS on univariate and multivariate analyses (p<0.05). Conclusion The MTV obtained from initial FDG PET/CT scan is a significant prognostic factor for disease recurrence and mortality in locally advanced HNSCC treated with surgery and radiotherapy with or without chemotherapy.

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Section: Discussionmentioning

confidence: 99%

Prognostic Value of Metabolic Tumor Volume Measured by 18F-FDG PET/CT in Locally Advanced Head and Neck Squamous Cell Carcinomas Treated by Surgery

Choi

Yoo

Han

et al. 2010

Nucl Med Mol Imaging

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“…Gradientbased methods rely on a model that determines the appropriate threshold of activity on the basis of the signal-to-background ratio [59]. This method was shown to be accurate for segmenting PET images in a study of pharyngeal-laryngeal tumors [60].…”

Section: Source / Background Algorithmsmentioning

confidence: 99%

“…Careful comparison of FDG-PET, MRI and CT scans with the histopathology of resected tumour specimens shows that none of these three imaging modalities is [60]. However FDG-PET may be the most accurate of the three for the detection of head and neck cancer [106].…”

Section: Figurementioning

confidence: 99%

“…However FDG-PET may be the most accurate of the three for the detection of head and neck cancer [106]. Tumour volume determined by FDG-PET tends to be smaller on average than the volume determined by the other modalities but most closely approximates the true tumour volume [60]. Nevertheless some tumour regions that are apparent on CT or MRI may not be imaged on PET and in these cases an exclusive reliance on PET would potentially lead to geographic miss.…”

Section: Figurementioning

confidence: 99%

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Use of PET and PET/CT for Radiation Therapy Planning: IAEA expert report 2006–2007

MacManus

Nestle

Rosenzweig

et al. 2009

Radiotherapy and Oncology

334

197

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“…Accurate PET/CT image alignment is essential for precise delineation and localization of the gross target volume (GTV). ( 7 , 8 ) In addition, magnetic resonance imaging (MRI) provides high soft tissue contrast and is often required for target delineation, ( 9 , 10 ) especially for stereotactic radiosurgery (SRS) procedures. Different MRI sequences, such as T1, T2 or fluid attenuated inversion recovery (FLAIR), enhance different aspects of soft tissue, helping to distinguish the GTV from local edema.…”

Section: Introductionmentioning

confidence: 99%

Correction of motion‐induced misalignment in co‐registered PET/CT and MRI (T1/T2/FLAIR) head images for stereotactic radiosurgery

Xie

Ning

et al. 2010

J Applied Clin Med Phys

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The purpose was to evaluate and correct the co‐registration of diagnostic PET/CT and MRI/MRI images for stereotactic radiosurgery (SRS) using 3D volumetric image registration (3DVIR). The 3DVIR utilizes the homogeneity of color distribution over a volumetric anatomical landmark as the registration criterion with submillimeter accuracy. Fifty‐three PET/CT and MRI (T1, T2 and FLAIR) image sets of patients with brain lesions were acquired sequentially from a hybrid PET/CT or an MRI scanner with common diagnostic head holding devices. Twenty‐five sets of head 18normalF−FDG−PET/CT images were scanned over a 10‐minute interval and 14 whole‐body sets were scanned over a 30‐minute interval. Fourteen sets of MRI images were acquired, and each 3‐modal image set (T1, T2 and FLAIR) was scanned in sequence at time 0, ~5 and ~20 minutes. The misalignments in these “co‐registered” images were evaluated and corrected using the 3DVIR. Using the head immobilization devices commonly found in diagnostic PET/CT and MRI/MRI imaging, 80%–100% of these “co‐registered” images were identified as misaligned. For PET/CT, the magnitude of misalignment was 0.4°±0.5° and 0.7±0.4mm for 10‐minute scans, and 0.8°±1.2° and 2.7±1.7mm for 30‐minute scans. For MRI/MRI, the magnitude was 0.2°±0.4° and 0.3±0.2mm for 5‐minute scan intervals, and 1.1°±0.7° and 1.2±1.4mm for 20‐minute intervals. Small, but significant, misalignment is present in the co‐registered diagnostic PET/CT and MRI/MRI images and can be corrected in SRS treatment planning using the volumetric image registration for improved target localization within the clinical error tolerance.PACS numbers: 87.53.Ly, 87.57.nj, 87.57.uk, 87.57.Q‐, 87.61.jc, 87.19.xcConflict of Interest Statement: The authors do not have any conflict of interest on this research report.

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Tumor Volume in Pharyngolaryngeal Squamous Cell Carcinoma: Comparison at CT, MR Imaging, and FDG PET and Validation with Surgical Specimen

Abstract: Compared with GTVs at CT and MR imaging, GTVs at FDG PET were smaller. In nine patients for whom a surgical specimen was available, PET was found to be the most accurate modality. However, no modality managed to depict superficial tumor extension.

Cited by 622 publications

References 18 publications

Prognostic Value of Metabolic Tumor Volume Measured by 18F-FDG PET/CT in Locally Advanced Head and Neck Squamous Cell Carcinomas Treated by Surgery

Prognostic Value of Metabolic Tumor Volume Measured by 18F-FDG PET/CT in Locally Advanced Head and Neck Squamous Cell Carcinomas Treated by Surgery

Use of PET and PET/CT for Radiation Therapy Planning: IAEA expert report 2006–2007

Correction of motion‐induced misalignment in co‐registered PET/CT and MRI (T1/T2/FLAIR) head images for stereotactic radiosurgery

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