Tumors and tumor resection alter circadian rhythms

Bever, Savannah R.; Dib, Patrick; Strehle, Lindsay D.; Haynes, Byron; Hilvert, A.M.; McKim, Daniel B.; Godbout, Jonathan P.; Sheridan, John F.; Obrietan, Karl; Pyter, Leah M.

doi:10.1016/j.bbi.2017.07.077

Cited by 2 publications

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Diurnal Variations in Immunity

Zhao

Chen

2019

Encyclopedia of Life Sciences

View full text Add to dashboard Cite

Many aspects of immune systems show diurnal variations depending on environmental and physical conditions, which are driven by internal circadian biological clocks and have been widely observed. Diurnal oscillations of immune mediators coordinate with the activity of the immune system, possibly allowing the host to anticipate and handle microbial threats more efficiently. These oscillations may also contribute to stimulation of organ proliferation, recovery and the clearance of potentially harmful cellular elements from the circulation. In addition, abnormal diurnal oscillations in immune system are associated with inflammation response induced by disorders or dysregulation of behaviour, physiology, metabolism, disease symptoms or response to drugs treatment. The overview of diurnal variations perspective of human immune system may provide novel strategies in clinical treatment. Key Concepts Diurnal variations in immunity exist widely in nature. Diurnal variations in immunity show differences between species, for example mouse and human. Diurnal variations in immunity are regulated by clock genes. Disruptions of circadian oscillations of immune system are closely associated with human diseases. Chrono‐immunotherapeutics should be attracting more attention in clinical treatment.

show abstract